Results 51 to 60 of about 1,259,124 (381)

YAP regulates cell mechanics by controlling focal adhesion assembly

Nature Communications, 2017
Hippo effectors YAP/TAZ act as on–off mechanosensing switches by sensing modifications in extracellular matrix (ECM) composition and mechanics. The regulation of their activity has been described by a hierarchical model in which elements of Hippo pathway
G. Nardone, Jorge Oliver-De La Cruz, Jan Vrbsky, Cecilia Martini, J. Přibyl, P. Skládal, M. Pešl, G. Caluori, S. Pagliari, Fabiana Martino, Zuzana Macečková, M. Hajdůch, Andres Sanz-Garcia, Nicola Maria Pugno, G. Stokin, G. Forte   +15 more
semanticscholar   +1 more source

The Focal Adhesion Analysis Server: a web tool for analyzing focal adhesion dynamics [v1; ref status: indexed, http://f1000r.es/yc]

F1000Research, 2013
The Focal Adhesion Analysis Server (FAAS) is a web-based implementation of a set of computer vision algorithms designed to quantify the behavior of focal adhesions in cells imaged in 2D cultures.
Matthew E Berginski, Shawn M Gomez
doaj   +1 more source

Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer progression

Cell Death and Disease, 2023
Numerous studies have investigated the various cellular responses against genotoxic stress, including those mediated by focal adhesions. We here identified a novel type of focal adhesion remodelling that occurs under genotoxic stress conditions, which ...
Masatsune Tsujioka, Keisuke Miyazawa, Masaki Ohmuraya, Yoichi Nibe, Tetsuya Shirokawa, Haruko Hayasaka, Tsunekazu Mizushima, Takeshi Fukuma, Shigeomi Shimizu   +8 more
doaj   +1 more source

Directing cell migration and organization via nanocrater-patterned cell-repellent interfaces. [PDF]

, 2015
Although adhesive interactions between cells and nanostructured interfaces have been studied extensively, there is a paucity of data on how nanostructured interfaces repel cells by directing cell migration and cell-colony organization.
Grigoropoulos, Costas P., Healy, Kevin, Jeon, Hojeong, Koo, Sangmo, Loskill, Peter, Reese, Willie   +5 more
core   +2 more sources

The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review

Journal of experimental & clinical cancer research : CR, 2019
FAK is a tyrosine kinase overexpressed in cancer cells and plays an important role in the progression of tumors to a malignant phenotype. Except for its typical role as a cytoplasmic kinase downstream of integrin and growth factor receptor signaling ...
Jin Zhou, Qian Yi, Liling Tang
semanticscholar   +1 more source

NEDD9 stabilizes focal adhesions, increases binding to the extra-cellular matrix and differentially effects 2D versus 3D cell migration.

PLoS ONE, 2012
The speed of cell migration on 2-dimensional (2D) surfaces is determined by the rate of assembly and disassembly of clustered integrin receptors known as focal adhesions.
Jessie Zhong, Jaime B Baquiran, Navid Bonakdar, Justin Lees, Yu Wooi Ching, Elena Pugacheva, Ben Fabry, Geraldine M O'Neill   +7 more
doaj   +1 more source

Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells

Journal of experimental & clinical cancer research : CR, 2019
Focal adhesion kinase (FAK) is a cytoplasmatic protein tyrosine kinase that associates with both integrins and growth factor receptors toward the adhesion, migration and invasion of cancer cells.
D. Rigiracciolo, M. Santolla, R. Lappano, A. Vivacqua, F. Cirillo, Giulia Raffaella Galli, M. Talia, L. Muglia, M. Pellegrino, N. Nohata, M. T. Di Martino, M. Maggiolini   +11 more
semanticscholar   +1 more source

Microtubule acetylation but not detyrosination promotes focal adhesion dynamics and astrocyte migration

Journal of Cell Science, 2019
Microtubules play a crucial role in mesenchymal migration by controlling cell polarity and the turnover of cell adhesive structures on the extracellular matrix. The polarized functions of microtubules imply that microtubules are locally regulated.
Bertille Bance, Shailaja Seetharaman, Cécile Leduc, B. Boëda, S. Étienne-Manneville   +4 more
semanticscholar   +1 more source

Differential regulation of adhesion complex turnover by ROCK1 and ROCK2. [PDF]

PLoS ONE, 2012
ROCK1 and ROCK2 are serine/threonine kinases that function downstream of the small GTP-binding protein RhoA. Rho signalling via ROCK regulates a number of cellular functions including organisation of the actin cytoskeleton, cell adhesion and cell ...
Frances E Lock, Katie R Ryan, Natalie S Poulter, Maddy Parsons, Neil A Hotchin   +4 more
doaj   +1 more source

Complementarity of PALM and SOFI for super-resolution live cell imaging of focal adhesions [PDF]

, 2016
Live cell imaging of focal adhesions requires a sufficiently high temporal resolution, which remains a challenging task for super-resolution microscopy.
Dedecker, Peter, Deschout, Hendrik, Feletti, Lely, Hofkens, Johan, Lasser, Theo, Leutenegger, Marcel, Lukes, Tomas, Radenovic, Aleksandra, Sharipov, Azat, Szlag, Daniel, Vandenberg, Wim   +10 more
core   +2 more sources