Results 51 to 60 of about 1,381,729 (387)
Surface Roughness Gradients Reveal Topography‐Specific Mechanosensitive Responses in Human Mesenchymal Stem Cells [PDF]
, 2020 The topographic features of an implant, which mechanically regulate cell behaviors and functions, are critical for the clinical success in tissue regeneration.
Camacho, Luis Cuellar +7 more
core +1 more source
Targeting Focal Adhesion Kinase Renders Pancreatic Cancers Responsive to Checkpoint Immunotherapy
Nature Medicine, 2016 Single-agent immunotherapy has achieved limited clinical benefit to date in patients with pancreatic ductal adenocarcinoma (PDAC). This may be a result of the presence of a uniquely immunosuppressive tumor microenvironment (TME).
Hong Jiang +12 more
semanticscholar +1 more source
YAP and TAZ limit cytoskeletal and focal adhesion maturation to enable persistent cell motility
Journal of Cell Biology, 2019 Cell migration initiates by traction generation through reciprocal actomyosin tension and focal adhesion reinforcement, but continued motility requires adaptive cytoskeletal remodeling and adhesion release.
Devon E. Mason +8 more
semanticscholar +1 more source
Diverse cell junctions with unique molecular composition in tissues of a sponge (Porifera)
EvoDevo, 2019 The integrity and organization of animal tissues depend upon specialized protein complexes that mediate adhesion between cells with each other (cadherin-based adherens junctions), and with the extracellular matrix (integrin-based focal adhesions ...
Jennyfer M. Mitchell, Scott A. Nichols
doaj +1 more source
Directing cell migration and organization via nanocrater-patterned cell-repellent interfaces. [PDF]
, 2015 Although adhesive interactions between cells and nanostructured interfaces have been studied extensively, there is a paucity of data on how nanostructured interfaces repel cells by directing cell migration and cell-colony organization.
Grigoropoulos, Costas P. +5 more
core +2 more sources
Focal adhesion kinase‐dependent regulation of adhesive forces involves vinculin recruitment to focal adhesions [PDF]
Biology of the Cell, 2010 Background information. FAK (focal adhesion kinase), an essential non‐receptor tyrosine kinase, plays pivotal roles in migratory responses, adhesive signalling and mechanotransduction. FAK‐dependent regulation of cell migration involves focal adhesion turnover dynamics as well as actin cytoskeleton polymerization and lamellipodia protrusion.
David W, Dumbauld +3 more
openaire +2 more sources
Structural and mechanistic insights into mechanoactivation of focal adhesion kinase
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Nonreceptor tyrosine kinases are major players in cell signaling. Among them, focal adhesion kinase (FAK) is the key integrator of signals from growth factors and cell adhesion.
M. S. Bauer +11 more
semanticscholar +1 more source
YAP regulates cell mechanics by controlling focal adhesion assembly
Nature Communications, 2017 Hippo effectors YAP/TAZ act as on–off mechanosensing switches by sensing modifications in extracellular matrix (ECM) composition and mechanics. The regulation of their activity has been described by a hierarchical model in which elements of Hippo pathway
G. Nardone +15 more
semanticscholar +1 more source
F1000Research, 2013 The Focal Adhesion Analysis Server (FAAS) is a web-based implementation of a set of computer vision algorithms designed to quantify the behavior of focal adhesions in cells imaged in 2D cultures.
Matthew E Berginski, Shawn M Gomez
doaj +1 more source
Cell Death and Disease, 2023 Numerous studies have investigated the various cellular responses against genotoxic stress, including those mediated by focal adhesions. We here identified a novel type of focal adhesion remodelling that occurs under genotoxic stress conditions, which ...
Masatsune Tsujioka +8 more
doaj +1 more source