Results 81 to 90 of about 64,048 (160)

Regulation of pancreatic cancer aggressiveness by stromal stiffening [PDF]

, 2016
No abstract ...
A Neesse, AD Rhim, BC Özdemir, H Laklai, I Barbieri, JJ Lee, JK Mouw, JM Bailey, Michael F Olson, Nicola Rath, P Bailey, SR Hingorani, SR Hingorani, V Sanz-Moreno   +13 more
core   +1 more source

TNIK Regulates Cytoskeletal Organization to Promote Focal Adhesion Turnover and Mitosis in Lung Adenocarcinoma

Frontiers in Bioscience-Landmark
Background: Lung cancer is the primary cause of cancer-related mortality, but the molecular mechanisms behind this malignancy remain unclear.
Yao Li, Meng-yao Song, Xing Hu, Xue-hua Sun, Tao Zhang, Lu Zhang, Ying-xiong Wang, Qian Zhang, Chun-dong Zhang, Lian Zhang   +9 more
doaj   +1 more source

Targeting lemurs against cancer metastasis [PDF]

, 2014
No description ...
Giamas, Georgios, Xu, Yichen, Zhang, Hua
core   +2 more sources

The Role of Focal Adhesion Kinase in Sphingosine‐1‐Phosphate Induced Endothelial Barrier Enhancement

The FASEB Journal, 2008
Dynamic interactions between adherens junctions and cell‐matrix adhesions mediated by actin cytoskeleton regulate endothelial barrier function. Barrier‐enhancing agonist, sphingosine‐1‐phosphate (S1P), by binding its S1P receptor1 (S1P‐1) on the endothelial cell surface enhance endothelial monolayer integrity by Rac1‐mediated stabilization of ...
Tracy Lynn Thennes, Maria Konstantoulaki, Dolly Mehta   +2 more
openaire   +1 more source

Myofibroblast Differentiation by Transforming Growth Factor-ॆ1 Is Dependent on Cell Adhesion and Integrin Signaling via Focal Adhesion Kinase [PDF]

Journal of Biological Chemistry, 2003
Myofibroblast differentiation and activation by transforming growth factor-beta1 (TGF-beta1) is a critical event in the pathogenesis of human fibrotic diseases, but regulatory mechanisms for this effect are unclear. In this report, we demonstrate that stable expression of the myofibroblast phenotype requires both TGF-beta1 and adhesion-dependent ...
Victor J, Thannickal, Daniel Y, Lee, Eric S, White, Zongbin, Cui, Jose M, Larios, Raquel, Chacon, Jeffrey C, Horowitz, Regina M, Day, Peedikayil E, Thomas   +8 more
openaire   +2 more sources

Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the β1 integrin-RACK1 axis. [PDF]

, 2012
Trop-2 is a transmembrane glycoprotein upregulated in several human carcinomas, including prostate cancer (PrCa). Trop-2 has been suggested to regulate cell-cell adhesion, given its high homology with the other member of the Trop family, Trop-1/EpCAM ...
Alberti, Saverio, Languino, Lucia R., Li, Jing, Trerotola, Marco   +3 more
core   +2 more sources

Soya-cerebroside reduces IL-1β-induced MMP-1 production in chondrocytes and inhibits cartilage degradation: implications for the treatment of osteoarthritis

Food and Agricultural Immunology, 2019
Osteoarthritis (OA) commonly affects the synovial joint and is characterized by degradation of articular cartilage, which is largely mobilized by increased matrix metalloproteinase (MMP) activity.
Shan-Chi Liu, Chun-Hao Tsai, Tung-Ying Wu, Chang-Hai Tsai, Fuu-Jen Tsai, Jing-Gung Chung, Chih-Yang Huang, Jai-Sing Yang, Yuan-Man Hsu, Mei-Chin Yin, Yang-Chang Wu, Chih-Hsin Tang   +11 more
doaj   +1 more source

The Increase of pFAK and THBS1 Protein and Gene Expression Levels in Vascular Smooth Muscle Cells by Histamine-treated M1 Macrophages

Iranian Journal of Allergy, Asthma and Immunology, 2019
Atherosclerosis is developed due to the formation of atheroma plaques in the coronary arteries. In this process, M1 macrophages and vascular smooth muscle cells (VSMCs) are the main functional cells.
Mohsen Khosravi, Mohammad Najafi, Abdollah Amirfarhangi, Mahdi Karimi, Fahimeh Fattahi, Mohammad Shabani   +5 more
doaj   +1 more source

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. [PDF]

, 2019
Gene copy number alterations, tumor cell stemness, and the development of platinum chemotherapy resistance contribute to high-grade serous ovarian cancer (HGSOC) recurrence.
Anderson, Kristen, Barrie, Allison M, Bean, Lisa M, Chen, Xiao Lei, Connolly, Denise C, Cordasco, Edward A, Diaz Osterman, Carlos J, Fisch, Kathleen M, Fu, Guo, Győrffy, Balázs, Heino, Jyrki, Jean, Christine, Jiang, Shulin, Kleinschmidt, Elizabeth G, Kolev, Vihren N, Li, Jian, Mark, Adam M, McHale, Michael T, Molinolo, Alfredo, Ojalill, Marjaana, Ozmadenci, Duygu, Pachter, Jonathan A, Rappu, Pekka, Schlaepfer, David D, Stupack, Dwayne G, Sulzmaier, Florian J, Tancioni, Isabelle, Taylor, Kristin N, Uryu, Sean, Weaver, David T, Xu, Guorong   +30 more
core   +1 more source

Therapeutic effects of tyroservatide on metastasis of lung cancer and its mechanism affecting integrin–focal adhesion kinase signal transduction

Drug Design, Development and Therapy, 2016
Yu-ting Huang,1,* Lan Zhao,1,* Zheng Fu,1 Meng Zhao,1 Xiao-meng Song,1 Jing Jia,1 Song Wang,1 Jin-ping Li,1 Zhi-feng Zhu,1 Gang Lin,1,2 Rong Lu,1,2 Zhi Yao1,3 1Department of Immunology, Tianjin Medical University, Tianjin, 2Shenzhen Kangzhe ...
Huang YT, Zhao L, Fu Z, Zhao M, Song XM, Jia J, Wang S, Li JP, Zhu ZF, Lin G, Lu R, Yao Z   +11 more
doaj