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Advanced Functional Materials, EarlyView.A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo +7 more
wiley +1 more source
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Mechanotransduction and focal adhesions
Cell Biology International, 2012AbstractCellular FAs (focal adhesions) respond to internal and external mechanical stresses which make them prime candidates for mechanotransduction. Recent observations showed that the FA proteins including vinculin, FAK (FA kinase) and p130Cas are crucial for the ability of cells to transmit forces and to generate cytoskeletal tension.
Wolfgang H Goldmann
exaly +3 more sources
Trends in Cell Biology, 1997
The GTP-binding protein Rho regulates the assembly of focal adhesions and their associated bundles of actin filaments. Two different lines of research have converged to reveal how Rho might regulate assembly of these structures. One approach has been the identification of downstream effectors of Rho, whereas the other has been the exploration of the ...
K, Burridge +2 more
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The GTP-binding protein Rho regulates the assembly of focal adhesions and their associated bundles of actin filaments. Two different lines of research have converged to reveal how Rho might regulate assembly of these structures. One approach has been the identification of downstream effectors of Rho, whereas the other has been the exploration of the ...
K, Burridge +2 more
openaire +2 more sources
The International Journal of Biochemistry & Cell Biology, 1997
Focal adhesion kinase (FAK) is a member of a growing family of non-receptor protein tyrosine kinases. Though originally identified as a putative substrate for the oncogenic tyrosine kinase pp60v-src, it is now well-established that FAK tyrosine phosphorylation is induced by adhesion of cell surface integrins to extracellular matrix and by a variety of ...
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Focal adhesion kinase (FAK) is a member of a growing family of non-receptor protein tyrosine kinases. Though originally identified as a putative substrate for the oncogenic tyrosine kinase pp60v-src, it is now well-established that FAK tyrosine phosphorylation is induced by adhesion of cell surface integrins to extracellular matrix and by a variety of ...
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Focal adhesion kinase in cancer
Frontiers in Bioscience, 2003Focal adhesion kinase (FAK) is a non-receptor cytoplasmic tyrosine kinase that transmits signals important in modulating several cell functions, including proliferation, migration, and survival. Several different types of malignant tumors have been reported to express elevated levels of FAK protein in vivo, potentially pointing to a role for FAK in ...
Timothy P, Hecker, Candece L, Gladson
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Focal adhesions and assessment of cytotoxicity
Journal of Biomedical Materials Research, 1999Focal adhesions are highly ordered assemblies of transmembrane receptors, extracellular matrix proteins, and a large number of cytoplasmic proteins, including structural proteins, as well as tyrosine kinases, phosphatases, and their substrates. They are now accepted as a prime component of signal transduction.
van Kooten, TG +3 more
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pp125FAK in the Focal Adhesion
1996Integrins are a large superfamily of transmembrane adhesion molecules. In many types of cultured cells, integrins are concentrated in specialized sites called focal adhesions. Integrins are capable of transducing signals to the inside of the cell, which can effect cell migration, differentiation and growth, but the signaling mechanism of integrins has ...
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The inner lives of focal adhesions
Trends in Cell Biology, 2002In focal adhesions of eukaryotic cells, transmembrane receptors of the integrin family and a large set of adaptor proteins form the physical link between the extracellular substrate and the actin cytoskeleton. During cell migration, nascent focal adhesions within filopodia and lamellipodia make the initial exploratory contacts with the cellular ...
Wehrle-Haller, Bernhard, Imhof, Beat
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Focal adhesions: Structure and dynamics
Biology of the Cell, 2000Interactions of cells with the extracellular matrix are essential for the control of tissue remodelling, cell migration, and embryogenesis. At the cell—extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where transmembrane adhesion receptors provide a structural link between the actin cytoskeleton and the
V, Petit, J P, Thiery
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Visualizing the ‘backbone’ of focal adhesions
Emerging Topics in Life Sciences, 2018To understand how complex machines perform their functions, it is essential to map out the ‘blueprints’ of how their internal components are organized. Focal adhesions (FAs) are complex mechanobiological structures involved in a plethora of cell biological processes.
Samuel F. H. Barnett +1 more
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