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The Molecular Architecture of Focal Adhesions
Annual Review of Cell and Developmental Biology, 1995This article outlines the present knowledge of the architecture, molecular composition, and dynamics of focal contacts of adhesive animal cells. These structures, developed at the plasma membrane at sites where cells touch their substratum, are essential for cellular attachment in tissue formation during embryogenesis and wound healing.
B M, Jockusch +9 more
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Structure and function of focal adhesions
Current Opinion in Cell Biology, 2012Integrin-dependent cell adhesions come in different shapes and serve in different cell types for tasks ranging from cell-adhesion, migration, and the remodeling of the extracellular matrix to the formation and stabilization of immunological and chemical synapses.
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Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase
Nature Cell Biology, 2005Imaging studies implicate microtubule targeting of focal adhesions in focal adhesion disassembly, although the molecular mechanism is unknown. Here, we develop a model system of focal adhesion disassembly based on the finding that microtubule regrowth after nocodazole washout induces disassembly of focal adhesions, and that this disassembly occurs ...
Ellen J, Ezratty +2 more
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Focal adhesions – the cytoskeletal connection
Current Opinion in Cell Biology, 2000Cellular contacts with the extracellular matrix are regulated by the Rho family of GTPases through their effects on both the actin and the microtubule cytoarchitecture. Recent genetic, biochemical and structural data have highlighted the role played by a subset of actin-binding proteins in coupling integrins to cytoskeletal actin and in assembling ...
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Paxillin and focal adhesion signalling
Nature Cell Biology, 2000To facilitate a rapid response to environmental change, cells use scaffolding - or adaptor - proteins to recruit key components of their signal-transduction machinery to specific subcellular locations. Paxillin is a multi-domain adaptor found at the interface between the plasma membrane and the actin cytoskeleton.
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Focal Adhesion Kinase in Neuritogenesis
2007The transduction of extracellular signals through adhesion and guidance receptors into cytoskeleton reorganization underlies axon outgrowth and pathfinding decisions. The cytoplasmic protein tyrosine kinase focal adhesion kinase (FAK), a central regulator of cell motility phenomena during morphogenesis, is highly expressed in the developing nervous ...
Bonanomi D., Valtorta F.
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Heterogeneity of Focal Adhesions and Focal Contacts in Motile Fibroblasts
2018Cell-extracellular matrix (ECM) adhesion is an important property of virtually all cells in multicellular organisms. Cell-ECM adhesion studies, therefore, are very significant both for biology and medicine. Over the last three decades, biomedical studies resulted in a tremendous advance in our understanding of the molecular basis and functions of cell ...
Aleena, Gladkikh +3 more
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Focal Adhesions Function as a Mechanosensor
2014Focal adhesions (FAs) are complex plasma membrane-associated macromolecular assemblies that engage with the surrounding extracellular matrix (ECM) via integrin receptors and physically connect with the actin cytoskeleton through the recruitment of numerous FA-associated proteins.
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