Results 31 to 40 of about 27,806 (222)

Focal Segmental Glomerulosclerosis with Sjogren Syndrome: A Case Report

Turkish Journal of Internal Medicine, 2021
Sjogren's syndrome (SjS) is a chronic, slow-progressing, autoimmune and lymphoproliferative disease. The main symptoms of the syndrome are xerostomia and keratoconjuctivitis sicca as a result of chronic inflammatory infiltration of the salivary and ...
Mehmet Sezen, Abdülmecit Yıldız, Kamil Dilek, Mustafa Güllülü, Mahmut Yavuz, Ayşegül Oruç, Mehmet Fethullah Aydın, Alparslan Ersoy   +7 more
doaj   +1 more source

Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ α-1) and profilin 2 [PDF]

, 2016
Focal segmental glomerulosclerosis (FSGS) is a devastating form of nephrotic syndrome which ultimately leads to end stage renal failure (ESRF). Mutations in inverted formin 2 (INF2), a member of the formin family of actin-regulating proteins, have ...
Heath, Jennifer A, Heesom, Kate J, Rollason, Ruth, Saleem, Moin, Welsh, Gavin I, Wherlock, Matthew D   +5 more
core   +2 more sources

A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis [PDF]

, 2016
Focal segmental glomerulosclerosis (FSGS) is a syndrome that involves kidney podocyte dysfunction and causes chronic kidney disease. Multiple factors including chemical toxicity, inflammation, and infection underlie FSGS; however, highly penetrant ...
Andrey S. Shaw, Cheryl A. Winkler, Ghaidan Shamsan, Haiyang Yu, J. Michael White, Jeffrey B. Kopp, Jeffrey H. Miner, M. Christine Stander, Mark J. Daly, Matthew G. Sampson, Matthias Kretzler, Mykyta Artomov, Robi D. Mitra, Sanjay Jain, Sebastian Brähler, Van der Auwera   +15 more
core   +2 more sources

Mechanisms of Scarring in Focal Segmental Glomerulosclerosis

Kidney Diseases, 2021
Background: Focal segmental glomerulosclerosis (FSGS) is a histologic pattern characterized by focal glomerular scarring, which often progresses to systemic and diffuse glomerulosclerosis.
Ke Sun, Qionghong Xie, Chuan-Ming Hao
doaj   +1 more source

Pathophysiology of focal segmental glomerulosclerosis [PDF]

Pediatric Nephrology, 2007
Focal segmental glomerulosclerosis (FSGS) is a major cause of idiopathic steroid-resistant nephrotic syndrome (SRNS) and end-stage kidney disease (ESKD). In recent years, animal models and studies of familial forms of nephrotic syndrome helped elucidate some mechanisms of podocyte injury and disease progression in FSGS. This article reviews some of the
Reidy, Kimberly, Kaskel, Frederick J.
openaire   +2 more sources

Characterization of early disease status in treatment-naive male paediatric patients with Fabry disease enrolled in a randomized clinical trial. [PDF]

, 2015
Trial designThis analysis characterizes the degree of early organ involvement in a cohort of oligo-symptomatic untreated young patients with Fabry disease enrolled in an ongoing randomized, open-label, parallel-group, phase 3B clinical trial.MethodsMales
An Haack, Kristina, Bichet, Daniel G, Bénichou, Bernard, Clarke, Lorne A, Dostalova, Gabriela, Fainboim, Alejandro, Fellgiebel, Andreas, Forcelini, Cassiano, Hopkin, Robert J, Mauer, Michael, Najafian, Behzad, Ramaswami, Uma, Scott, C Ronald, Shankar, Suma P, Thurberg, Beth L, Tylki-Szymańska, Anna, Tøndel, Camilla, Wijburg, Frits A   +17 more
core   +6 more sources

Mucin-1 Gene Mutation and the Kidney: The Link between Autosomal Dominant Tubulointerstitial Kidney Disease and Focal and Segmental Glomerulosclerosis

Case Reports in Nephrology, 2018
Glomerular diseases are one of the most frequent causes of chronic kidney disease, focal and segmental glomerulosclerosis being one of the commonest glomerulopathies.
H. Trimarchi, M. Paulero, T. Rengel, I. González-Hoyos, M. Forrester, F. Lombi, V. Pomeranz, R. Iriarte, A. Iotti   +8 more
doaj   +1 more source

Progression of albuminuria and podocyte injury in focal segmental glomerulosclerosis inhibited by enhanced glycosphingolipid GM3 via valproic acid

Scientific Reports, 2023
Focal segmental glomerulosclerosis, characterized by decreased numbers of podocytes in glomeruli, is a common cause of refractory nephrotic syndrome. Recently, we showed that enhanced glycosphingolipid GM3 expression after administration of valproic acid,
Nagako Kawashima, Shokichi Naito, Masaki Nagane, Tadashi Yamashita, Ken-ichi Nakayama   +4 more
doaj   +1 more source

Impact of graft loss among kidney diseases with a high risk of post-transplant recurrence in the paediatric population [PDF]

, 2017
Background Some kidney diseases tend to recur in the renal allograft after transplantation. We studied the risk of graft loss among primary renal diseases known for their high risk of recurrence and compared it with that of patients with hypoplasia and ...
Belingheri, Mirco, Dudley, Jan, Dušek, Jiří, Grenda, Ryszard, Jager, Kitty J., Macher, Marie-Alice, Puretic, Zvonimir, Rubic, Jacek, Rudaitis, Sarunas, Rudin, Christoph, Schaefer, Franz, Szabó, Tamás, van Stralen, Karlijn J., Verrina, Enrico   +13 more
core   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source