Results 51 to 60 of about 27,806 (222)

From Single‐Cell Clusters to Causality: ITCH Engagement for CKD Uncovered by Integrative Analysis of MR and MAGMA

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
This graphical abstract illustrates an integrative analysis of single‐cell RNA‐seq data in CKD. DEGs were subsequently identified as candidate genes via Mendelian randomization analysis and combined with MAGMA analysis, ITCH was identified as a key gene.
Xia Zhang, Dongdong Zhang, Jiazhen Shang, Zhitao Zeng, Shouyu Chai, Xincong Lv, Zhimei Lv, Rong Wang   +7 more
wiley   +1 more source

Collapsing focal segmental glomerulosclerosis: Increasing the awareness [PDF]

Journal of Nephropathology, 2012
Collapsing focal segmental glomerulosclerosis (cFSGS), also known as collapsing glomerulopathy (CG) is of considerable interest for a variety of reasons.
Muhammed Mubarak
doaj   +1 more source

Familial collapsing focal segmental glomerulosclerosis [PDF]

Clinical Nephrology, 2011
The majority of patients with non-HIV-related collapsing focal segmental glomerular sclerosis (FSGS) have idiopathic disease. Only a few genetic forms associated with rare syndromes have been described in families. Here we report two families with multiple members who have collapsing FSGS with no clear associated secondary etiology.
V, Liakopoulos, A, Huerta, S, Cohen, M R, Pollak, R A, Sirota, K, Superdock, G B, Appel   +6 more
openaire   +2 more sources

Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial. [PDF]

, 2015
Apolipoprotein L1 gene (APOL1) G1 and G2 coding variants are strongly associated with chronic kidney disease (CKD) in African Americans (AAs). Here APOL1 association was tested with baseline estimated glomerular filtration rate (eGFR), urine albumin ...
Bild, Diane E, Divers, Jasmin, Freedman, Barry I, Hawfield, Amret T, Kaysen, George A, Kimmel, Paul L, Langefeld, Carl D, Pajewski, Nicholas M, Raj, Dominic S, Reboussin, David M, Ricardo, Ana C, Rocco, Michael V, Sedor, John R, Systolic Blood Pressure Intervention Trial (SPRINT), Wright, Jackson T   +14 more
core   +1 more source

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, Volume 78, Issue 3, Page 548-557, March 2026.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify noninvasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, for the Lupus Nephritis Classification Steering Committee   +11 more
wiley   +1 more source

Alendronate-associated focal segmental glomerulosclerosis [PDF]

Clinical Kidney Journal, 2008
Sir, Alendronate sodium, a bisphosphonate and commonly used pharmacologic agent for postmenopausal osteoporosis, has been rarely linked to renal toxicity [1] but not in association with focal segmental glomerulosclerosis (FSGS). A 55-year-old Caucasian woman developed proteinuria and hypertension.
Prikis, Marios, Gibson, Pamela C., Weise, Wolfgang J.   +2 more
openaire   +2 more sources

Mutational analysis of the PLCE1 gene in steroid-resistant nephrotic syndrome [PDF]

, 2010
International audienceBackground: Mutations in the PLCE1 gene encoding phospholipase C epsilon 1 (PLCε1) have been recently described in patients with early-onset nephrotic syndrome (NS) and diffuse mesangial sclerosis (DMS).
Audrey Pawtowski, Audrey Pawtowski, Chantal Loirat, Constantinos J, Corinne Antignac, Et Al. Mu, Fabien Nevo, Fabien Nevo, Georges Deschênes, Hal Id Inserm, Ilmay Bilge, Kenza Soulami, Lisa M. Guay, Marie-alice Macher, Marie-claire Gubler, Michelle Hall, Olivia Boyer, Olivia Boyer, Olivier Gribouval, Olivier Gribouval, Robert Weiss, Zelal Bircan   +21 more
core   +7 more sources

A Case of Intermittent Fever a Decade After Renal Transplantation

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Disseminated histoplasmosis is a potentially serious complication after organ transplantation; however, its occurrence is rare, even in endemic regions. Diagnosis can be challenging, particularly in patients with nonspecific symptoms such as intermittent fever or lethargy.
Merazul Islam Ony, Baris Afsar, Bahar Bastani   +2 more
wiley   +1 more source

Current distribution pattern of biopsy-proven glomerular disease in Salvador, Brazil, 40 years after an initial assessment

Brazilian Journal of Nephrology
Introduction: A report on the prevalence of glomerular disease diagnosed via renal biopsy in Salvador, BA, Brazil was published in 1973 and showed a predominance of membranoproliferative glomerulonephritis, which was frequently associated with ...
Washington Luis Conrado dos-Santos, Glória Maria Maranhão Sweet, Labene Gondim Azevêdo, Maria Brandão Tavares, Maria Fernanda Sanches Soares, Caroline Vilas Boas de Melo, Márcia Fernanda Melo Carneiro, Rilma Ferreira de Souza Santos, Márcia Cristina Conrado, Daniela Teixeira Leal Braga, Marcia Carvalho Bessa, Nathanael de Freitas Pinheiro Junior, Marília Bahiense-Oliveira   +12 more
doaj   +1 more source

The renal response to FGF23 shifts from phosphaturia toward inflammation in kidney disease

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
Abstract FGF23 excess is associated with morbidity and mortality, but the role of excessive circulating FGF23 concentrations as a causative factor of pathology is controversial. Here, we investigated the consequences of FGF23 excess in kidney disease. This study used three disease models: anti‐glomerular basement membrane (anti‐GBM) disease, Adriamycin
Matthias B. Moor, Mikhail Burmakin, Anna Levin, Gül Gizem Korkut, David Brodin, Annika Wernerson, Annette Bruchfeld, Peter Bárány, Anna Witasp, Jaakko Patrakka, Hannes Olauson   +10 more
wiley   +1 more source