Results 51 to 60 of about 14,325,085 (286)

Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes [PDF]

, 2013
Protective responses to microorganisms involve the nonspecific but rapid defence mechanisms of the innate immune system, followed by the specific but slow defence mechanisms of the adaptive immune system. Located as sentinels at the interface between the
Cols, M, Cerutti, A, Andrea Cerutti, Puga, I, Montserrat Cols, Irene Puga   +5 more
core   +1 more source

Molecular Mechanisms Regulating T Helper 1 versus T Follicular Helper Cell Differentiation in Humans

Cell Reports, 2016
IL-12 is important for the differentiation of T follicular helper (Tfh) cells, as well as Th1 cells in humans. Still, how IL-12 signals regulate Tfh versus Th1 cell differentiation remains poorly characterized.
Nathalie Schmitt, Yang Liu, Salah-Eddine Bentebibel, Hideki Ueno   +3 more
doaj   +1 more source

Follicular helper T-cell–related lymphomas [PDF]

Blood, 2015
In this issue of Blood, Wang et al describe the occurrence and pathogenetic relevance of IDH2R172 mutations in angioimmunoblastic T-cell lymphoma (AITL).
openaire   +2 more sources

CD4 T follicular helper cells in HIV    

, 2022
HIV infects millions of individuals worldwide, and new things still emerge. Once infected, the virus cannot be cleared by the system and causes non-heritable immunological disorder syndrome. Combination antiretroviral therapeutic program effectively suppresses microorganism replication and halts malady progression.
Cebo,Daniel, Weiss,Jochen, Dimity,Carolina   +2 more
openaire   +1 more source

Heterogeneity of Phenotype and Function Reflects the Multistage Development of T Follicular Helper Cells

Frontiers in Immunology, 2017
T follicular helper cells (Tfh) provide crucial signals for germinal center (GC) formation, but Tfh populations are heterogeneous. While PD1hi Tfh are important in the GC response, the function of the PD1lo Tfh-like subset is unknown.
David Gray, Marta Trüb, Tom A. Barr, Vicky L. Morrison, Sheila Brown, Stefano Caserta, Jordan Rixon, Alasdair Ivens   +7 more
doaj   +1 more source

METTL3-dependent m6A modification programs T follicular helper cell differentiation

Nature Communications, 2021
T follicular helper (TFH) cells are specialized effector CD4+ T cells that are critical in humoral immunity, but the function of post-transcriptional regulation is not clearly defined.
Yingpeng Yao, Ying Yang, Wenhui Guo, Lifan Xu, Menghao You, Yi-Chang Zhang, Zhen Sun, Xiao Cui, Guotao Yu, Zhihong Qi, Jingjing Liu, Fang Wang, Juanjuan Liu, Tianyan Zhao, Lilin Ye, Yun-Gui Yang, Shuyang Yu   +16 more
doaj   +1 more source

Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death

Frontiers in Immunology, 2021
Follicular helper T (TFH) cells are specialized CD4+ helper T cells that provide help to B cells in humoral immunity. However, the molecular mechanism underlying generation of TFH cells is incompletely understood.
Lingtao Yang, Wei Chen, Li Li, Yueyue Xiao, Shilin Fan, Quan Zhang, Tian Xia, Mengjie Li, Yazhen Hong, Tongjin Zhao, Qiyuan Li, Wen-Hsien Liu, Nengming Xiao   +12 more
doaj   +1 more source

Diagnostic Challenges in Nodal T-Follicular Helper (TFH) Cell Lymphoma

BioMed
Nodal T-follicular helper cell lymphomas comprise a biologically similar but morphologically diverse family of T-cell neoplasms, including angioimmunoblastic T-cell lymphoma, nodal T-follicular helper cell lymphoma, follicular-type, and nodal TFH ...
Neha Seth, Phyu Thin Naing, Pratik Q. Deb   +2 more
doaj   +1 more source

CD4+ T Follicular Helper Cells in Human Tonsils and Blood Are Clonally Convergent but Divergent from Non-Tfh CD4+ Cells

Cell Reports, 2020
Summary: T follicular helper (Tfh) cells are fundamental for B cell selection and antibody maturation in germinal centers. Circulating Tfh (cTfh) cells constitute a minor proportion of the CD4+ T cells in peripheral blood, but their clonotypic ...
Elena Brenna, Alexey N. Davydov, Kristin Ladell, James E. McLaren, Paolo Bonaiuti, Maria Metsger, James D. Ramsden, Sarah C. Gilbert, Teresa Lambe, David A. Price, Suzanne L. Campion, Dmitriy M. Chudakov, Persephone Borrow, Andrew J. McMichael   +13 more
doaj   +1 more source

Signaling Pathways in T Follicular Helper Cells [PDF]

The Journal of Immunology, 2010
Abstract Th cell functional subsets have unique transcriptional programs that form the molecular basis for T cell differentiation and functions. T follicular helper (TFH) cells have emerged as the main providers of T cell help to B cells during the germinal center (GC) reaction, where B cells undergo selection events through ...
Julia, Rolf, Kirsten, Fairfax, Martin, Turner   +2 more
openaire   +2 more sources