Results 221 to 230 of about 42,818 (256)

Exposure to micro‐ and nano‐plastics: From human internal burden to systems‐level health‐risk interpretation

iMeta, EarlyView.
Micro‐ and nano‐plastics (MNPs) can enter the human body through inhalation, ingestion, contact with consumer products, and iatrogenic routes. The clinical relevance of MNP exposure should be interpreted at three levels: barrier interaction, cellular stress, and system‐level disruption, with key mechanisms including oxidative stress, mitochondrial ...
Chen Tu, Jie Yang, Jingyi Liao, Rongkui Hu, Yudong Feng, Di Wu, Yankai Xia, Dan Wang, Jinrong Tang, Xianzheng Yuan, Dong Zhu, Jing Wei, Li Xu, Mingkai Xu, Xuetao Guo, Jian Zhao, Qiqing Chen, Zhenming Zhang, Lianzhen Li, Yini Ma, Xiaoxu Jiang, Kai Zhang, Cheng Peng, Mengyao Li, Ning Shen, Willie J. G. M. Peijnenburg, Matthias C. Rillig, Jason C. White, Yongming Luo, Ningwei Zhao   +29 more
wiley   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

A successful in vitro fertilization outcome in a hermaphrodite male

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 424-425, April 2025.
Shima Elbakhit M. E. Albasha, Sami Saadi Al‐Said, Haitham Tharwat M. H. El Bardisi   +2 more
wiley   +1 more source

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T follicular helper cells and T follicular regulatory cells in rheumatic diseases

Nature Reviews Rheumatology, 2019
As a hallmark of autoimmune rheumatic diseases, autoantibodies have been used in diagnosis for decades. However, the immunological mechanism underlying their generation has only become clear following the identification of T follicular helper (TFH) cells and T follicular regulatory (TFR) cells. TFH cells are instrumental in supporting antibody affinity
Valter R Fonseca, Luis Graça, Jun Deng   +2 more
exaly   +6 more sources

Revealing T follicular helper cells with BCL6

Nature Reviews Immunology, 2021
Shane Crotty discusses three independent studies published in 2009 that characterized T follicular helper cells as a distinct subset of CD4+ T cells on the basis of selective expression of BCL6.
Shane Crotty, Crotty Shane
exaly   +3 more sources

T follicular helper cells in space-time

Nature Reviews Immunology, 2016
T follicular helper (TFH) cells play a crucial part in the development of humoral immunity by controlling the formation of, and the cellular reactions that occur in, germinal centres. Within these organized lymphoid tissue microstructures, B cells proliferate and somatically mutate to produce long-lived, high-affinity plasma cells and memory B cells ...
Hai Qi, Qi Hai
exaly   +3 more sources

Follicular T helper cells and cutaneous T-cell lymphomas

British Journal of Dermatology, 2022
Abstract Linked Article:  Wang et al. Br J Dermatol 2022; 187:970–980.
openaire   +2 more sources

T follicular helper cells in autoimmune diseases

Journal of Autoimmunity, 2023
T follicular helper (Tfh) cells with the phenotype of mainly expressing surface molecules C-X-C motif chemokine receptor type 5 (CXCR5), inducible co-stimulator (ICOS), secreting cytokine interleukin-21 (IL-21) and requiring the transcription factor B cell lymphoma 6 (BCL-6) have been recently defined as a new subset of CD4+ T cells.
Xindi Wei, Xiaoyin Niu
openaire   +2 more sources

Follicular helper T cells in rheumatoid arthritis

Clinical Rheumatology, 2015
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation in the joints and other tissues. Rheumatoid factor (RF) and anticyclic citrullinated peptides (anti-CCP) are biomarkers for the evaluation of RA although their functions in the pathogenesis of RA are poorly understood.
Meixing, Yu, Vanesssa, Cavero, Qiao, Lu, Hong, Li   +3 more
openaire   +2 more sources

Noncanonical functions of T follicular helper cells

Science Immunology
T follicular helper cells (T FH cells) are essential for germinal center (GC) formation and maintenance. However, recent insights reveal that T FH cells play additional immune regulatory roles beyond their traditional B cell helper function.
Shivangi Dave, André Ballesteros-Tato
openaire   +2 more sources