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T follicular helper cells in food allergy
Current Opinion in ImmunologyT follicular helper (Tfh) cells help direct the production of antibodies by B cells. In addition to promoting antibody responses to vaccination and infection, Tfh cells have been found to mediate antibody production to food antigens. Work over the past decade has delineated the specific phenotypes of Tfh cells that induce antibodies to food while also ...
Jennifer S, Chen +2 more
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Revisiting the follicular helper T cell paradigm
Nature Immunology, 2009Antibody responses are critical for host protection against many pathogens. By reporting what actually occurs in vivo, two new studies provide important clues about follicular helper T cells that are dedicated to providing help to B cells.
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T follicular helper cells in human autoimmunity
Current Opinion in Immunology, 2016Studies with mouse models have established the pathogenic roles of T follicular helper (Tfh) cells in antibody-mediated autoimmune diseases. In contrast, evidence in human autoimmune pathogenesis has been lacking for years. Recent progress in understanding on the biology of human Tfh cells and on the approaches assessing their response has enabled ...
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Follicular helper T cells and fibrotic diseases
Cellular ImmunologyT follicular helper (Tfh) cells constitute a functionally specialized subset of CD4+ T lymphocytes that orchestrate germinal center (GC) responses, critically regulating B cell destination and the development of long-term humoral immunity. Emerging evidence implicates Tfh cells as key mediators in the pathogenesis of multiple fibrotic disorders across ...
Yixuan, Ma, Yue, Zhou, Miao, Yu
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Cytokine Expression by T Follicular Helper Cells
2017T follicular helper (Tfh) cells are a specialized subset of CD4+ T cells located within temporary structures known as germinal centers (GC) formed within B cell follicles of secondary lymphoid organs. In the GC, Tfh cells facilitate the production of high-affinity antibodies through secretion of effector cytokines, such as IL-21 and IL-4, and through ...
Christoph, Jandl +2 more
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Laboratory Investigation
Angioimmunoblastic T-cell lymphoma (AITL), the most common form of peripheral T-cell lymphoma, originates from follicular helper T (Tfh) cells and is notably resistant to current treatments. The disease progression and maintenance, at least in early stages, are driven by a complex interplay between neoplastic Tfh and clusters of B-cells within the ...
Tania P. Sainz +9 more
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Angioimmunoblastic T-cell lymphoma (AITL), the most common form of peripheral T-cell lymphoma, originates from follicular helper T (Tfh) cells and is notably resistant to current treatments. The disease progression and maintenance, at least in early stages, are driven by a complex interplay between neoplastic Tfh and clusters of B-cells within the ...
Tania P. Sainz +9 more
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Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19
Cell, 2020Ciputra Hartana +2 more
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