Immune architecture of oocyte competence: from development to senescence. [PDF]
Front ImmunolJiang MX, Zhu Y, Feng HL.
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The influence of Epstein-Barr virus in the microenvironment of classic Hodgkin lymphoma: a focus on T-cells and macrophages. [PDF]
Hematol Transfus Cell TherFrota Melo AC +5 more
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Destroyed Melanocytes Manifested with Poliosis and Halo Nevi in Children: Proposed Immunopathophysiological Mechanisms with Emphasis on Hair Follicle Immune Privilege. [PDF]
Clin PractBulat V +5 more
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Expression of V‑domain Ig suppressor of T cell activation in ovarian cancer and its regulation of follicular regulatory T‑cell function via the AKT/MAPK pathway. [PDF]
Oncol RepMa Y, Xu Y, Yu C, Wu H, Li L.
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T Follicular Helper Cells and T Follicular Regulatory Cells in Rheumatic Diseases
Nature Reviews Rheumatology, 2019 As a hallmark of autoimmune rheumatic diseases, autoantibodies have been used in diagnosis for decades. However, the immunological mechanism underlying their generation has only become clear following the identification of T follicular helper (TFH) cells and T follicular regulatory (TFR) cells. TFH cells are instrumental in supporting antibody affinity
Valter R Fonseca, Luis Graca, Jun Deng
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The expanding family of T follicular regulatory cells
Science Immunology, 2023The coevolution of multiple specialized T follicular regulatory cell subsets has led to fine-tuning of human germinal center responses in providing optimal antibody production and preventing events leading to autoimmunity (see the related Research Article by Le Coz et al .).
Luis Graca +2 more
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T Follicular Regulatory Cells in Mice and Men [PDF]
Immunology, 2017 SummaryIt has long been known that CD4 T cells are necessary to provide help to B cells, triggering a germinal centre (GC) reaction where affinity maturation and isotype switching occur. However, the nature of the dedicated CD4 helper T cells, known as T follicular helper (Tfh), was only recently described.
Valter R Fonseca +2 more
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Follicular Regulatory T Cells Impair Follicular T Helper Cells in HIV and SIV Infection [PDF]
Nature Communications, 2015 AbstractHuman and simian immunodeficiency viruses (HIV and SIV) exploit follicular lymphoid regions by establishing high levels of viral replication and dysregulating humoral immunity. Follicular regulatory T cells (TFR) are a recently characterized subset of lymphocytes that influence the germinal centre response through interactions with follicular ...
Martin McCarter +2 more
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Introduction: Immune thrombocytopenia (ITP) is an autoimmune disease characterized by thrombocytopenia. Herein, we sought to identify potential immune-related therapeutic targets in ITP. Methods: The differentially expressed genes (DEGs) between ITP patients and controls in GSE43177 and PRJNA299534 were analyzed. The intersections of the two DEG groups
Mingling, Sun +8 more
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SummaryPathogen exposure elicits production of high‐affinity antibodies stimulated by T follicular helper (Tfh) cells in the germinal center reaction. Tfh cells provide both costimulation and stimulatory cytokines to B cells to facilitate affinity maturation, class switch recombination, and plasma cell differentiation within the germinal center.
Peter T, Sage, Arlene H, Sharpe
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