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Developmental bifurcation of human T follicular regulatory cells
Science Immunology, 2021Transcriptomics supports that human T reg cells differentiate into mature lymphoid tissue or circulating T follicular regulatory cells.
Saumya Kumar +13 more
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Journal of Leukocyte Biology, 2020
Abstract Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease, characterized by lymphocytic infiltration into exocrine glands, which causes dry eyes, dry mouth, and systemic damage. Although the precise etiology of pSS is not clear yet, highly activated B cells, abundant anti-SSA/Ro, and anti-SSB/La autoantibodies are the ...
Weiqian, Chen +4 more
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Abstract Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease, characterized by lymphocytic infiltration into exocrine glands, which causes dry eyes, dry mouth, and systemic damage. Although the precise etiology of pSS is not clear yet, highly activated B cells, abundant anti-SSA/Ro, and anti-SSB/La autoantibodies are the ...
Weiqian, Chen +4 more
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Current Advances in Follicular Regulatory T-Cell Biology
Critical Reviews in Immunology, 2022Follicular regulatory T (T<sub>FR</sub>) cells are a population of CD4<sup>+</sup> T-cells that concomitantly express markers for regulatory T-cells and follicular helper T (T<sub>FH</sub>) cells, and have been predominantly implicated in the regulation of humoral immunity via their suppressive functions.
Sadashib, Ghosh, Jianmei W, Leavenworth
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2021
With the compiling studies on the autoimmune pathogenesis in the developing of Sjögren's syndrome, the functional importance of T follicular helper cells (Tfh) and T follicular regulatory cells (Tfr) was investigated, including our recent findings, among which various techniques for detecting Tfh and Tfr cells in Sjögren's syndrome have been reported ...
Sulan, Yu +5 more
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With the compiling studies on the autoimmune pathogenesis in the developing of Sjögren's syndrome, the functional importance of T follicular helper cells (Tfh) and T follicular regulatory cells (Tfr) was investigated, including our recent findings, among which various techniques for detecting Tfh and Tfr cells in Sjögren's syndrome have been reported ...
Sulan, Yu +5 more
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Effects of allergen immunotherapy on follicular regulatory T cells
Current Opinion in Allergy & Clinical Immunology, 2023Purpose of review Emerging evidence indicating that the dysfunction of T follicular regulatory (T FR ) cells contributes to excessive immunoglobulin E (IgE) production and the development of allergic diseases.
Shi-Ran, Sun, Yin, Yao, Zheng, Liu
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T follicular helper and T follicular regulatory cells in colorectal cancer: A complex interplay
Journal of Immunological Methods, 2020Colorectal cancer is considered to be one of the major causes of morbidity and mortality all over the world. T Follicular helper (TFH) and T follicular regulatory (TFR) cells are specialized providers of T-cells to help B-cells and shaping germinal centers (GC) response.
Helal F, Hetta +6 more
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Advances in T follicular helper and T follicular regulatory cells in transplantation immunity
Transplantation Reviews, 2018B cells play a crucial role in alloreactivity of organ transplant rejection and graft versus host diseases (GVHD). Over the past decade, it has been well recognized that B-cell infiltration in allografts and de novo donor-specific antibodies (DSA) were strongly associated with severe graft rejection and loss, as well as glucocorticoid resistance ...
Maogen Chen +5 more
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The Journal of Immunology, 2023
Abstract Development of high-affinity Abs in the germinal center (GC) is dependent on a specialized subset of T cells called “T follicular helper” (TFH) cells that help select Ag-specific B cells. A second T cell subset, T follicular regulatory (TFR) cells, can act as repressors of the GC and Ab response but can also provide a helper ...
Qiang Chen, Alexander L Dent
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Abstract Development of high-affinity Abs in the germinal center (GC) is dependent on a specialized subset of T cells called “T follicular helper” (TFH) cells that help select Ag-specific B cells. A second T cell subset, T follicular regulatory (TFR) cells, can act as repressors of the GC and Ab response but can also provide a helper ...
Qiang Chen, Alexander L Dent
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Indian Journal of Pediatrics, 2023
To investigate the role of follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells in immune disorders of idiopathic membranous nephropathy (IMN).Peripheral blood samples of 41 IMN patients and 30 healthy controls were collected.
Lin, Xu +4 more
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To investigate the role of follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells in immune disorders of idiopathic membranous nephropathy (IMN).Peripheral blood samples of 41 IMN patients and 30 healthy controls were collected.
Lin, Xu +4 more
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Identifying Follicular Regulatory T Cells by Confocal Microscopy
2017Follicular regulatory T cells are a subset of Foxp3+ regulatory T cells that migrate into the B cell follicle after infection or immunization and modulate the germinal center response. The anatomical positioning of follicular regulatory T cells within the germinal center is a defining characteristic of this subset of regulatory T cells; because of this,
Ine, Vanderleyden, Michelle A, Linterman
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