Results 1 to 10 of about 6,058 (120)

Differential expression of follistatin and FLRG in human breast proliferative disorders [PDF]

BMC Cancer, 2009
Background Activins are growth factors acting on cell growth and differentiation. Activins are expressed in high grade breast tumors and they display an antiproliferative effect inducing G0/G1 cell cycle arrest in breast cancer cell lines.
Amaral Vania F, Grasso Giovanni, Muscettola Michela, Borges Lavinia E, Mencarelli Marzia, Ciarmela Pasquapina, Massai Lauretta, Couto Henrique L, Bloise Enrrico, Cassali Geovanni D, Petraglia Felice, Reis Fernando M   +11 more
doaj   +4 more sources

Follistatin-Related Protein and Follistatin Differentially Neutralize Endogenous vs. Exogenous Activin [PDF]

Endocrinology, 2002
Follistatin-related protein (FSRP) is a new addition to the expanding follistatin (FS)-related gene family whose members contain at least one conserved 10-cysteine follistatin domain. In contrast to other members of this family, FSRP and follistatin also share a common exon/intron domain structure, substantial primary sequence homology, and an ability ...
Yisrael, Sidis, Drew V, Tortoriello, William E, Holmes, Yang, Pan, Henry T, Keutmann, Alan L, Schneyer   +5 more
openaire   +3 more sources

Follistatin-Like Proteins: Structure, Functions and Biomedical Importance

Biomedicines, 2021
Main forms of cellular signal transmission are known to be autocrine and paracrine signaling. Several cells secrete messengers called autocrine or paracrine agents that can bind the corresponding receptors on the surface of the cells themselves or their ...
Olga K. Parfenova, Vladimir G. Kukes, Dmitry V. Grishin   +2 more
doaj   +1 more source

Human Follistatin-Related Protein: A Structural Homologue of Follistatin with Nuclear Localization [PDF]

Endocrinology, 2001
Follistatin-related protein is a recently discovered glycoprotein that is highly homologous in both primary sequence and exon/intron domain structure to the activin-binding protein, follistatin. We explored their potential for functional redundancy by investigating the relative affinities and kinetics of their interactions with activin, bone ...
D V, Tortoriello, Y, Sidis, D A, Holtzman, W E, Holmes, A L, Schneyer   +4 more
openaire   +3 more sources

Identification of Differential Expression Cytokines in Hemolysis, Elevated Liver Enzymes, and Low Platelet Syndrome by Proteome Microarray Analysis and Further Verification

Cell Transplantation, 2021
To screen the differential expression cytokines (DECs) in hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome, establish its differential cytokines spectra, and provide the clues for its diagnosis and pathogenic mechanism researches ...
Suya Kang, Liping Zhou, Yun Wang, Hui Li, Hong Zhang   +4 more
doaj   +1 more source

miR-200c-3p Regulates Epitelial-to-Mesenchymal Transition in Epicardial Mesothelial Cells by Targeting Epicardial Follistatin-Related Protein 1 [PDF]

International Journal of Molecular Sciences, 2021
Recent findings suggest that epithelial to mesenchymal transition (EMT), a key step during heart development, is involved in cardiac tissue repair following myocardial infarction (MI). MicroRNAs (miRNAs) act as key regulators in EMT processes; however, the mechanisms by which miRNAs target epicardial EMT remain largely unknown.
Elena Pontemezzo, Eleonora Foglio, Enza Vernucci, Alessandra Magenta, Marco D’Agostino, Sara Sileno, Elena Astanina, Federico Bussolino, Laura Pellegrini, Antonia Germani, Matteo Antonio Russo, Federica Limana   +11 more
openaire   +3 more sources

Characterization of Insulin-like Peptide (ILP) and Its Potential Role in Ovarian Development of the Cuttlefish Sepiella japonica

Current Issues in Molecular Biology, 2022
The insulin-like peptide (ILP) family is well known for regulating reproduction in invertebrates, while its role in mollusks remains largely unknown. In this study, we first isolated and characterized the ILP gene in the cuttlefish Sepiella japonica. The
Zhenming Lü, Chenghao Yao, Shijie Zhao, Yao Zhang, Li Gong, Bingjian Liu, Liqin Liu   +6 more
doaj   +1 more source

In-vitro study of the effect of anti-hypertensive drugs on placental hormones and angiogenic proteins synthesis in pre-eclampsia [PDF]

, 2014
Antihypertensive drugs lower the maternal blood pressure in pre-eclampsia (PE) by direct or central vasodilatory mechanisms but little is known about the direct effects of these drugs on placental ...
Gangooly, S, Jauniaux, E, Muttukrishna, S   +2 more
core   +7 more sources

Baicalin attenuates LPS-induced alveolar type II epithelial cell A549 injury by attenuation of the FSTL1 signaling pathway via increasing miR-200b-3p expression

Innate Immunity, 2021
In China, baicalin is the main active component of Scutellaria baicalensis , which has been used in the treatment of inflammation-related diseases, such as inflammation-induced acute lung injury. However, its specific mechanism remains unclear.
Xin-ya Duan, Yang Sun, Zhu-fen Zhao, Yao-qing Shi, Xun-yan Ma, Li Tao, Ming-wei Liu   +6 more
doaj   +1 more source

Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders

Frontiers in Endocrinology, 2021
Obesity is a global health problem and a major risk factor for several metabolic conditions including dyslipidemia, diabetes, insulin resistance and cardiovascular diseases.
Shehla Pervin, Shehla Pervin, Srinivasa T. Reddy, Srinivasa T. Reddy, Rajan Singh, Rajan Singh, Rajan Singh   +6 more
doaj   +1 more source