Localization of inhibins and activins in normal endocrine cells and endocrine tumors of the gut and pancreas: an immunohistochemical and in situ hybridization study [PDF]
Activins and inhibins, which belong to the TGF beta family, are composed of different combinations of alpha-, betaA-, and betaB-subunits, resulting in inhibin A (alphabetaA), inhibin B (alphabetaB), activin A (betaAbetaA), activin B (betaBbetaB), and ...
Capella, C +4 more
core +1 more source
Follistatin‐related protein/follistatin‐like 1 evokes an innate immune response via CD14 and toll‐like receptor 4 [PDF]
FRP physically interacts with CD14 by fluorescence‐activated cell sorting (View interaction)
Murakami, Kosaku +13 more
openaire +2 more sources
Systemic activation of activin A signaling causes chronic kidney disease-mineral bone disorder [PDF]
The high cardiovascular mortality associated with chronic kidney disease (CKD) is caused in part by the CKD-mineral bone disorder (CKD-MBD) syndrome.
Sugatani, Toshifumi
core +2 more sources
Abstract Background: Follistatin-like 1 (FSTL1) plays both pro-inflammatory and anti-inflammatory roles in the inflammatory processes. We investigated whether serum FSTL1 could predict the current anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV)-specific indices ...
Taejun Yoon +6 more
openaire +4 more sources
Cardiac Remodeling: Endothelial Cells Have More to Say Than Just NO
The heart is a highly structured organ consisting of different cell types, including myocytes, endothelial cells, fibroblasts, stem cells, and inflammatory cells.
Vincent F. M. Segers +5 more
doaj +1 more source
Oocytes prevent cumulus cell apoptosis by maintaining a morphogenic paracrine gradient of bone morphogenetic proteins [PDF]
© The Company of Biologists Ltd 2005Paracrine factors secreted by the oocyte regulate a broad range of cumulus cell functions. Characteristically, cumulus cells have a low incidence of apoptosis and we proposed that this is due to oocyte-secreted factors
Amato, F. +4 more
core +2 more sources
Human activin-A is expressed in the atherosclerotic lesion and promotes the contractile phenotype of smooth muscle cells [PDF]
Activin is a member of the transforming growth factor-beta superfamily, and it modulates the proliferation and differentiation of various target cells. In this study, we investigated the role of activin in the initiation and progression
Achterberg, T.A.E. (Tanja) van +6 more
core +3 more sources
Sarcopenia is linked to the decline in muscle mass, strength and function during aging. It affects the quality and life expectancy and can lead to dependence.
Janire Alonso-Puyo +7 more
doaj +1 more source
Ameliorative effects of follistatin‐related protein/TSC‐36/FSTL1 on joint inflammation in a mouse model of arthritis [PDF]
AbstractObjectiveTo clarify the in vivo function of follistatin‐related protein (FRP)/TSC‐36/FSTL1 in rheumatoid arthritis (RA), we investigated the roles of FRP in a mouse model of arthritis.MethodsArthritis was induced in BALB/c mice by injecting anti–type II collagen monoclonal antibody and lipopolysaccharide.
Daisuke, Kawabata +7 more
openaire +2 more sources
Regulation of follistatin-related gene (FLRG) expression by protein kinase C and prostaglandin E2 in cultured granulosa-luteal cells [PDF]
Activin and its binding protein follistatin may act as local regulators of cell growth and steroidogenesis in the human ovary. The recently identified follistatin-related gene (FLRG) is expressed abundantly in the human ovary, has high affinity for activin, and is able to inhibit activin-induced transcriptional responses. However, little is known about
J, Liu +3 more
openaire +2 more sources

