Results 31 to 40 of about 12,893 (183)

Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor (TGF ) signaling is essential for testicular aging and regulating testis size [PDF]

, 2013
Follistatin-like 3 (FSTL3) is a glycoprotein that binds and inhibits the action of TGFβ ligands such as activin. The roles played by FSTL3 and activin signaling in organ development and homeostasis are not fully understood.
Abir Mukherjee, Alan L. Schneyer, Andrew A. Pitsillides, Archambeault, Baker, Bakker, Bartholin, Bastow, Besset, Brehm, Chan, Cohen, Cooke, Cooke, Cooke, Coultas, Coussens, Dierich, Do, Fujita, Gill, Hardwick, Itman, Jan Seebacher, Johnston, Judit Villen, Karla J. Oldknow, Kato, Kato, Kooy, Kumar, Lee, Matzuk, Mukherjee, Nef, Noriega, Parvinen, Peter J. O'Shaughnessy, Salisbury, Shang, Sharpe, Sidis, Slegtenhorst-Eegdeman, St-Pierre, Steeno, Steven P. Gygi, Tanimoto, Tapasree Goswami, Tolonen, Tsuchida, Turek, Wilhelm, Wreford, Xia, Yang   +54 more
core   +1 more source

Serum Concentrations of Myostatin and Myostatin-Interacting Proteins do not differ between young and Scarcopenic elderly men [PDF]

, 2011
Peer ...
A. DeVries, A. Joyson, A. M. Tommasi, A. Ratkevicius, Amin, Baumgartner, C. A. Greig, C. Grierson, Carlson, Clark, D. Crowther, D. M. Reid, F. Gilbert, Gonzalez-Cadavid, GREIG, H. Wackerhage, Hameed, I. Selmer, J. Brady, K. C. H. Fearon, Lakshman, Lauretani, Lee, Lexell, Moreland, Newman, P. Rauchhaus, P. Yaworsky, Pahor, Payette, Rantanen, Rommel, Rosenberg, S. Alesci, Schuelke, Siriett, Streckis, T. Dhanani, T. W. Redpath, Wagner, Wolfe, Zimmers   +41 more
core   +1 more source

Autocrine Signaling in Cardiac Remodeling: A Rich Source of Therapeutic Targets

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
The myocardium consists of different cell types, of which endothelial cells, cardiomyocytes, and fibroblasts are the most abundant. Communication between these different cell types, also called paracrine signaling, is essential for normal cardiac ...
Vincent F. M. Segers, Gilles W. De Keulenaer   +1 more
doaj   +1 more source

Characterization of a Rat C₆ Glioma‐Secreted Follistatin‐Related Protein (FRP) [PDF]

European Journal of Biochemistry, 1994
A protein was isolated from rat C6 glioma‐conditioned medium and was biochemically characterized. The heparin‐binding protein has a native molecular mass of 55–75000Da, a molecular mass of 40–48000 Da under denaturing conditions, and a pI of 5.0–6.0. Based on the determined partial amino acid sequences, the full lenght cDNA encoding the rat and human ...
Zwijsen, An, Blockx, Herman, Van Arnhem, Wouter, Willems, Jean, Fransen, Lucie, Devos, Kathleen, Raymackers, Jos, Van de Voorde, André, Slegers, Herman   +8 more
openaire   +3 more sources

The Myostatin Propeptide and the Follistatin-related Gene Are Inhibitory Binding Proteins of Myostatin in Normal Serum [PDF]

Journal of Biological Chemistry, 2002
Myostatin, also known as growth and differentiation factor 8, is a member of the transforming growth factor beta superfamily that negatively regulates skeletal muscle mass (1). Recent experiments have shown that myostatin activity is detected in serum by a reporter gene assay only after activation by acid, suggesting that native myostatin circulates as
Jennifer J, Hill, Monique V, Davies, Adele A, Pearson, Jack H, Wang, Rodney M, Hewick, Neil M, Wolfman, Yongchang, Qiu   +6 more
openaire   +2 more sources

AFP, PIVKAII, GP3, SCCA-1 and follisatin as surveillance biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty liver disease

BMC Cancer, 2008
Background The incidence and mortality of hepatocellular cancer (HCC) complicating alcoholic and non-alcoholic fatty liver diseases (ALD and NAFLD) is rising in western societies.
Trerotoli Paolo, Day Christopher, Hudson Mark, Stewart Stephen, Gray Joe, Chattopadhyay Dipankar, Beale Gary, Giannelli Gianluigi, Manas Derek, Reeves Helen   +9 more
doaj   +1 more source

The spatiotemporal expression pattern of the bone morphogenetic protein family in rat ovary cell types during the estrous cycle. [PDF]

, 2003
In the mammalian ovary, great interest in the expression and function of the bone morphogenetic protein (BMP) family has been recently generated from evidence of their critical role in determining folliculogenesis and female fertility.
Erickson, Gregory F, Shimasaki, Shunichi
core   +3 more sources

The activin binding proteins follistatin and follistatin-related protein are differentially regulated in vitro and during cutaneous wound repair [PDF]

Journal of Endocrinology, 2001
Follistatin is a secreted protein that binds activin in vitro and in vivo and thereby inhibits its biological functions. Recently, related human and murine genes, designated follistatin-related gene (FLRG), were identified, and their products were shown to bind activin with high affinity.
M, Wankell, S, Kaesler, Y Q, Zhang, C, Florence, S, Werner, R, Duan   +5 more
openaire   +2 more sources

Comparison of bioactivities, binding properties and intra-follicular levels of bovine follistatins [PDF]

, 2015
Five isoforms of follistatin (FST) (Mr 31, 33, 35, 37, 41kDa) were purified from bovine follicular fluid (bFF). Comparison of their activin- and heparan sulphate proteoglycan (HSP)-binding properties and bio-potencies in neutralization of activin-A ...
Boland, Maurice P., Glister, Claire, Ireland, James J., Knight, Phil G., Sunderland, Simon J.   +4 more
core   +1 more source

Follistatin‐related protein/follistatin‐like 1 evokes an innate immune response via CD14 and toll‐like receptor 4 [PDF]

FEBS Letters, 2012
FRP physically interacts with CD14 by fluorescence‐activated cell sorting (View interaction)
Murakami, Kosaku, Tanaka, Masao, Usui, Takashi, Kawabata, Daisuke, Shiomi, Aoi, Iguchi-Hashimoto, Mikiko, Shimizu, Masakazu, Yukawa, Naoichiro, Yoshifuji, Hajime, Nojima, Takaki, Ohmura, Koichiro, Fujii, Takao, Umehara, Hisanori, Mimori, Tsuneyo   +13 more
openaire   +2 more sources