Results 51 to 60 of about 12,893 (183)

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass [PDF]

, 2013
Although the canonical transforming growth factor β signaling pathway represses skeletal muscle growth and promotes muscle wasting, a role in muscle for the parallel bone morphogenetic protein (BMP) signaling pathway has not been defined. We report,
Amthor, Amthor, Ball, Bayat, Bianca C. Bernardo, Bodine, Bogdanovich, Bradley J. Turner, Catherine E. Winbanks, Chung, Claudia Beyer, Clever, Cohen, Craig A. Harrison, Donaldson, Dworkin, Dworkin, Fischle, Gregorevic, Grönroos, Gurney, Hayashi, Heitman, Holley, Hongwei Qian, Ibebunjo, Imamura, Ishida, Julie R. McMullen, Justin L. Chen, Kalista, Kambadur, Katagiri, Kevin I. Watt, Langenfeld, Lars Larsson, Latres, Lee, Lee, Lee, Massagué, Mathews, McCabe, McPherron, Moresi, Musarò, Nakao, Nickel, Ochala, Paul Gregorevic, Pescatori, Potthoff, Pourquié, Rachel E. Thomson, Rafael, Rebbapragada, Rommel, Ruschke, Sako, Sandri, Sartori, Sartori, Sean L. McGee, Shioi, Stitt, Suryawan, Tang, Timothy Connor, Townsend, Trendelenburg, Winbanks, Winbanks, Yamamoto, Yingying Liu, Zhou, Zimmerman   +75 more
core   +2 more sources

Follistatin-like 5 is expressed in restricted areas of the adult mouse brain: Implications for its function in the olfactory system [PDF]

, 2014
Follistatin‐like 5 (Fstl5), a member of the follistatin family of genes, encodes a secretory glycoprotein. Previous studies revealed that other members of this family including Fstl1 and Fstl3 play an essential role in development, homeostasis, and ...
Masuda Tomoyuki, Nagaoka Atsuko, Nagase Takahiro, Sakuma Chie, Ueda Shuichi, Yaginuma Hiroyuki, Yamagishi Toshiyuki, 増田 知之   +7 more
core   +2 more sources

Maternal plasma levels of follistatin‐related gene protein in the first trimester of pregnancies with Down syndrome

Prenatal Diagnosis, 2010
AbstractObjectiveTo determine maternal plasma levels of follistatin‐related gene protein (FLRG) in the first trimester of pregnancy and assess its potential role as a marker for prenatal screening of Down syndrome.MethodsMaternal plasma levels of FLRG were determined in 100 pregnant women with normal fetuses in their first trimester of pregnancy (i.e ...
Miron, P., Lambert, J., Marcil, A., Cowans, N. J., Stamatopoulou, A., Spencer, K.   +5 more
openaire   +3 more sources

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

PACAP induces FSHβ gene expression via EPAC. [PDF]

, 2019
Gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are heterodimers of a common α subunit and unique β subunits. Regulation of their levels, primarily by GnRH, is critical for reproductive function.
Coss, Djurdjica, Yeh, Debra M
core  

Molecular Characterization of the Follistatin (FST) Gene in Quail and its Modulation through Natural Agonists [PDF]

Brazilian Journal of Poultry Science
Follistatin (FST) is a cysteine-rich monomeric protein capable of binding and neutralizing the action of several members of the transforming growth factor-beta (TGFβ) family, such as myostatin and activin, by binding to their receptors.
UlF Hassan, S Aftab, MS Rehman, S Arif, M Safdar, S Ahmed, K Ahmad, AD Cerbo, MM Azzam, M Alagawany   +9 more
doaj   +1 more source

An Integrated Gene Regulatory Network Controls Stem Cell Proliferation in Teeth [PDF]

, 2012
Epithelial stem cells reside in specific niches that regulate their self-renewal and differentiation, and are responsible for the continuous regeneration of tissues such as hair, skin, and gut.
Alonso, Maria T, Chuong, Cheng-Ming, Felszeghy, Szabolcs, Maas, Richard Louis, Plikus, Maksim V, Schimmang, Thomas, Suomalainen, Marika, Thesleff, Irma, Wang, Xiu-Ping, Zelarayan, Laura C   +9 more
core   +1 more source

Different effect of follistatin-related protein (FRP)in ox-LDLinduced endothelial cell and vascular smooth muscle cell apoptosis [PDF]

Heart, 2011
Background The development of atherosclerosis proceeds through multiple maladaptive pathways that begins with endothelial cell (EC)injury caused by oxidised low-density lipoprotein (ox-LDL) which plays a critical role. Proliferation and migration of vascular smooth muscle cells (VSMCs) also play an important role in
null Shenhua, Liu Yuyang, Wang Zhijian, Yang Shiwei, null Hanhongya, Ge Hailong, Xiao-Li Liu, null Jiadean, Gao fei   +8 more
openaire   +1 more source

Strategies for Monitoring Serum Protein Degradation With an Antibody Array‐Based Technology

Journal of Clinical Laboratory Analysis, EarlyView.
This study analyzed the stability of 480 proteins in human serum samples collected from 10 healthy donors and incubated at room temperature for 0–48 h. Antibody array profiling revealed significant time‐dependent degradation of 201 proteins. Subsequent physicochemical and functional enrichment analyses demonstrated that the degraded proteins were ...
Yanlin Wang, Min Lang, Wei Huang, Siwei Zhu, Yingqing Mao, Shuhong Luo, Hua Dong, Ruo‐Pan Huang   +7 more
wiley   +1 more source

Identification of ActivinβA and Gonadotropin Regulation of the Activin System in the Ovary of Chinese Sturgeon Acipenser sinensis

Animals
Activin is a dimeric growth factor with diverse biological activities in vertebrates. This study aimed to investigate the regulatory role of the activin signaling pathway in the ovary of the endangered, cultured sturgeon species Acipenser sinensis.
Huamei Yue, Huan Ye, Rui Ruan, Hao Du, Chuangju Li   +4 more
doaj   +1 more source