Results 41 to 50 of about 476,073 (321)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Detection of H5N1 highly pathogenic avian influenza virus RNA in filth flies collected from California farms in 2024

Scientific Reports
The emergence of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b in U.S. dairy cattle highlights the urgent need to understand transmission dynamics within and among farms.
Dana Nayduch, Stacey L.P. Scroggs, Phillip Shults, Luke A. Brendel, Lindsey M. Reister-Hendricks, Caitlin Taylor, Edward Bird, Brina Lopez, Edith S. Marshall   +8 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Practices towards prevention of food borne diseases among females in rural area of Trichy, India

, 2018
Background: Food borne diseases are of great importance since it leads to multiple health problems resulting in illness, malnutrition, mortality and economic loss.
Kumarasamy Hemalatha, Parthiban, Elavarasan, Hemalatha, Kumarasamy, Parthipan, Kathirvel, Elango, S., S. Parkavi, Kathirvel Parthipan, Elavarasan Parthiban, S. Elango, Parkavi, S.   +9 more
core   +2 more sources

Investigations by the Institut Hospitalo-Universitaire Méditerranée Infection of food and food-borne infections in the Mediterranean Basin and in sub-Saharan Africa

New Microbes and New Infections, 2018
Food-borne infections are major causes of public health concern in developing and developed countries. During the past decade, the Institut Hospitalo-Universitaire Méditerranée Infection has conducted or been involved in multiple investigations that ...
C. Abat, J.-M. Rolain, P. Colson
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Taeniosis and cysticercosis in Serbia, 1990–2018: Significance of standard of living

International Journal of Infectious Diseases, 2019
Objectives: As is the case for all of Southeast Europe, Serbia is an area traditionally endemic for Taenia saginata and Taenia solium infections. This study was performed to analyse the epidemiological data on taeniosis and cysticercosis in Serbia for ...
Milena Stopić, Branko Bobić, Zorica Dakić, Jelena Srbljanović, Tijana Štajner, Neda Konstantinović, Katarina Srećković, Ivana Klun, Miloš Korać, Olgica Djurković-Djaković   +9 more
doaj   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Influence of inoculation dose and route on EHDV-8 distribution and the induced immune response in experimentally infected cattle

Veterinary Research
Epizootic haemorrhagic disease virus serotype 8 (EHDV-8) is an emerging Culicoides-borne virus that was first detected in Europe in autumn 2022 in Italy and subsequently spread to Spain, Portugal and France.
Ilse De Leeuw, Ruben Villalba, Montserrat Aguëro, Laurent Mostin, Nick De Regge   +4 more
doaj   +1 more source

Effect of Extracts and Bacteria from Korean Fermented Foods on the Control of Sesame Seed-Borne Fungal Diseases

Research in Plant Disease, 2015
In order to control seed-borne diseases, we obtained extracts from commercial fermented food products of Kimchi, Gochujang, Doenjang, Ganjang and Makgeolli and their suppressive effects against seed-borne diseases were studied.
Yong-Ki Kim, Sung-Jun Hong, Chang-Ki Shim, Min-Jeong Kim, Jong-Ho Park, Eun-Jung Han, Jong-Won Park, So-Hyang Park, Hyeong-Jin Jee, Seok-Cheol Kim   +9 more
doaj   +1 more source