Results 41 to 50 of about 1,328 (234)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Gender Difference in Food Choice and Eating Practice and Their Association with Health among Students of Kathmandu, Nepal

Journal of Obesity, 2022
Background. Our eating practice is generally based on the food we choose to eat. The selection of unhealthy food, high cost of healthy food items, and easy availability of fast food may have negative impact on our health and eating behaviour.
Maginsh Dahal, Alisha Basnet, Sudip Khanal, Kushalata Baral, Smriti Dhakal   +4 more
doaj   +1 more source

Relationships Among Food Choice Motivators, Food Insecurity, and Academic Outcomes

Journal of Hunger & Environmental Nutrition, 2023
To identify relationships between food choice motivators (FCM) and food security in university students, a questionnaire assessing food security and FCM was distributed in Winter 2020 to 10,000 university students (1,535 responses; 1,408 included in demographic analysis, 1,189 included in other analyses).
Loofbourrow, Brittany M., Blue, Mary C., Jones, Anna M., Martinez, Suzanna M., Kemp, Leslie C., George, Gretchen L., Scherr, Rachel E.   +6 more
openaire   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Do pandemics influence food choice motives, diet, and health behaviors? Evidence from a cross-sectional survey in Pakistan during the COVID-19 pandemic

BMC Nutrition
Background COVID-19 has significantly impacted the health and well-being of individuals by influencing their diet and lifestyle. Therefore, this study was designed to compare the dietary and health practices pre- and post-COVID-19 infection and to study ...
Rida Khan, Afifa Tanweer, Sanaullah Iqbal   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Do urban tourists prefer vegetarianism? An urban-rural comparison of vegetarian consumption in China

Frontiers in Nutrition, 2022
The adoption of a vegetarian diet might have public health and environmental benefits. However, little is known about urban and rural Generation Z tourists' attitudes toward vegetarianism or vegetarian consumption within the Chinese urban and rural ...
Guoyi Chen, Wei Tan, Ning Ran, Jiansheng Zhang, Bangquan Yan   +4 more
doaj   +1 more source

Are the Motives for Food Choices Different in Orthorexia Nervosa and Healthy Orthorexia? [PDF]

Nutrients, 2019
Recent research points to the bidimensional nature of orthorexia, with one dimension related to interest in healthy eating (healthy orthorexia) and another dimension related to a pathological preoccupation with eating healthily (orthorexia nervosa). Research was needed to provide further support for this differentiation.
Julia Depa, Juan Ramón Barrada, María Roncero   +2 more
openaire   +5 more sources