Results 111 to 120 of about 4,268,320 (289)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
FOOD ASSISTANCE AND NUTRITION RESEARCH SMALL GRANTS PROGRAM: EXECUTIVE SUMMARIES OF 2002 RESEARCH GRANTS [PDF]
This report summarizes research findings from the Food Assistance and Nutrition Research Small Grants Program. The Economic Research Service created the program in 1998 to stimulate new and innovative research on food assistance and nutrition issues and ...
Tiehen, Laura
core +1 more source
Overfishing Trends and the Global Food Crisis [PDF]
, 2010 Fish are a vital source of nourishment, especially to people in the world's poorest nations. Widespread over?shing has led to a decline in catch globally; however, the links between over?shing and food security have not been well-understood.
Rashid Sumaila +3 more
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Editorial: Impression management strategies and environmental cues as focal factors in food research
Frontiers in Nutrition, 2023 Tobias Otterbring +2 more
doaj +1 more source
FOOD ASSISTANCE AND NUTRITION RESEARCH SMALL GRANTS PROGRAM: EXECUTIVE SUMMARIES OF 2003 RESEARCH GRANTS [PDF]
This report summarizes research findings from the Food Assistance and Nutrition Research Small Grants Program. The Economic Research Service created the program in 1998 to stimulate new and innovative research on food assistance and nutrition issues and ...
Anonymous, Tiehen, Laura
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source