Promyelocytic leukemia protein (PML) controls breast cancer cell proliferation by modulating Forkhead transcription factors [PDF]
Molecular Oncology, 2019 The multitasking promyelocytic leukemia (PML) protein was originally recognized as a tumor‐suppressive factor, but more recent evidence has implicated PML in tumor cell prosurvival actions and poor patient prognosis in specific cancer settings.
Nikoleta Sachini +7 more
doaj +3 more sources
DNA-Binding Specificity Changes in the Evolution of Forkhead Transcription Factors [PDF]
Proc Natl Acad Sci U S A, 2013 The evolution of transcriptional regulatory networks entails the expansion and diversification of transcription factor (TF) families. The forkhead family of TFs, defined by a highly conserved winged helix DNA-binding domain (DBD), has diverged into ...
Bulyk, Martha Leonia +4 more
core +3 more sources
Role of Forkhead Transcription Factors in Diabetes-Induced Oxidative Stress [PDF]
Exp Diabetes Res, 2012 Diabetes is a chronic metabolic disorder, characterized by hyperglycemia resulting from insulin deficiency and/or insulin resistance. Recent evidence suggests that high levels of reactive oxygen species (ROS) and subsequent oxidative stress are key ...
Bhaskar Ponugoti +2 more
semanticscholar +3 more sources
Toward a mechanistic understanding of DNA binding by forkhead transcription factors and its perturbation by pathogenic mutations [PDF]
Nucleic Acids Res, 2021 Forkhead box (FOX) proteins are an evolutionarily conserved family of transcription factors that play numerous regulatory roles in eukaryotes during developmental and adult life.
S. Dai, Linzhi Qu, Jun Li, Yongheng Chen
semanticscholar +2 more sources
Mechanism of forkhead transcription factors binding to a novel palindromic DNA site [PDF]
Nucleic Acids Res, 2021 Forkhead transcription factors bind a canonical consensus DNA motif, RYAAAYA (R = A/G, Y = C/T), as a monomer. However, the molecular mechanisms by which forkhead transcription factors bind DNA as a dimer are not well understood.
Jun Li +12 more
semanticscholar +2 more sources
Role of the Forkhead Transcription Factors Fd4 and Fd5 During Drosophila Leg Development [PDF]
Frontiers in Cell and Developmental Biology, 2021 Appendage development requires the coordinated function of signaling pathways and transcription factors to pattern the leg along the three main axes: the antero-posterior (AP), proximo-distal (PD), and dorso-ventral (DV).
Mireya Ruiz-Losada +2 more
doaj +2 more sources
Bidirectional regulation of osteogenic differentiation by the FOXO subfamily of Forkhead transcription factors in mammalian MSCs [PDF]
Cell Prolif, 2018 Through loss‐ and gain‐of‐function experiments in knockout and transgenic mice, Forkhead box O (FOXO) family transcription factors have been demonstrated to play essential roles in many biological processes, including cellular proliferation, apoptosis ...
Duanjing Chen +5 more
semanticscholar +2 more sources
Dbf4 recruitment by forkhead transcription factors defines an upstream rate-limiting step in determining origin firing timing [PDF]
Genes Dev, 2017 Fang et al. show that Dbf4 is enriched at early origins through its interaction with forkhead transcription factors Fkh1 and Fkh2. Dbf4 interacts directly with Sld3 and promotes the recruitment of downstream limiting factors.
Dingqiang Fang +10 more
semanticscholar +2 more sources
Forkhead transcription factors: new considerations for alzheimer’s disease and dementia [PDF]
J Transl Sci, 2016 Life expectancy of individuals in both developed and undeveloped nations continues to rise at an unprecedented rate. Coupled to this increase in longevity for individuals is the rise in the incidence of chronic neurodegenerative disorders that includes ...
K. Maiese
semanticscholar +2 more sources
Molecular Cancer, 2019 Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide and the fourth most frequent cause of death having an oncological origin. It has been found that transcription factors (TF) dysregulation, leading to the significant expression
Paul Laissue
doaj +2 more sources