Results 1 to 10 of about 56,919 (302)
Role of the Forkhead Transcription Factors Fd4 and Fd5 During Drosophila Leg Development [PDF]
Frontiers in Cell and Developmental Biology, 2021 Appendage development requires the coordinated function of signaling pathways and transcription factors to pattern the leg along the three main axes: the antero-posterior (AP), proximo-distal (PD), and dorso-ventral (DV).
Mireya Ruiz-Losada +2 more
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Promyelocytic leukemia protein (PML) controls breast cancer cell proliferation by modulating Forkhead transcription factors [PDF]
Molecular Oncology, 2019 The multitasking promyelocytic leukemia (PML) protein was originally recognized as a tumor‐suppressive factor, but more recent evidence has implicated PML in tumor cell prosurvival actions and poor patient prognosis in specific cancer settings.
Nikoleta Sachini +7 more
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FOXOs and their roles in acute and chronic neurological disorders [PDF]
Frontiers in Molecular BiosciencesThe forkhead family of transcription factors of class O (FOXOs) consisting of four functionally related proteins, FOXO1, FOXO3, FOXO4, and FOXO6, are mammalian homologs of daf-16 in Caenorhabditis elegans and were previously identified as tumor ...
Yasin Asadi +14 more
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Structural plasticity of the FOXO-DBD:p53-TAD interaction [PDF]
Nature CommunicationsThe transcription factors FOXO4 and p53 regulate aging, and their deregulation has been linked to several diseases, including cancer. Under stress conditions, cellular senescence is promoted by p53 sequestration and senescence-associated protein p21 ...
Klara Kohoutova +4 more
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The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. [PDF]
PLoS Biology, 2007 Parkinson disease affects more than 1% of the population over 60 y old. The dominant models for Parkinson disease are based on the use of chemical toxins to kill dopamine neurons, but do not address the risk factors that normally increase with age ...
Raja Kittappa +3 more
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npj Systems Biology and Applications, 2021 Networks of interacting molecules organize topology, amount, and timing of biological functions. Systems biology concepts required to pin down ‘network motifs’ or ‘design principles’ for time-dependent processes have been developed for the cell division ...
Matteo Barberis
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The Role of Forkhead Box Family in Bone Metabolism and Diseases
Frontiers in Pharmacology, 2022 Forkhead box (Fox) family, an evolutionarily conserved family of transcription factors carrying the “Forkhead” motif, plays an indispensable role in human health and disease.
Jianxiang Xu +18 more
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Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes
Frontiers in Neuroscience, 2022 Forebrain development in vertebrates is regulated by transcription factors encoded by homeobox, bHLH and forkhead gene families throughout the progressive and overlapping stages of neural induction and patterning, regional specification and generation of
Ryan F. Leung +12 more
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Cancer Cell International, 2023 Glioma is the most aggressive and malignant type of primary brain tumor, comprises the majority of central nervous system deaths, and is categorized into different subgroups according to its histological characteristics, including astrocytomas ...
Peyman Tabnak +3 more
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Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells. [PDF]
PLoS ONE, 2009 Forkhead box M1 (FoxM1) oncogenic transcription factor represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors.
Uppoor G Bhat +2 more
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