Missense variants in human forkhead transcription factors reveal determinants of forkhead DNA bispecificity [PDF]
Cell RepSummaryRecognition of specific DNA sequences by transcription factors (TFs) is a key step in transcriptional control of gene expression. While most forkhead (FH) TFs bind either an FKH (RYAAAYA) or an FHL (GACGC) recognition motif, some FHs can bind both motifs.
Jessica King +5 more
europepmc +3 more sources
Forkhead transcription factors in ovarian function [PDF]
REPRODUCTION, 2011 Since the discovery of the conserved forkhead (Fkh) DNA binding domain more than 20 years ago, members of the Fkh or forkhead box (FOX) family of transcription factors have been shown to act as important regulators of numerous developmental and homeostatic processes.
N. Henriette Uhlenhaut, Mathias Treier
semanticscholar +4 more sources
Forkhead Transcription Factors and Cardiovascular Biology [PDF]
Circ Res, 2008 The Forkhead family of transcription factors modulates a wide variety of cellular functions in cardiovascular tissues. In this review article, we discuss recent advances in our understanding of regulation provided by the forkhead factors in cardiac myocytes and vascular cells.
Kyriakos N. Papanicolaou +2 more
europepmc +4 more sources
Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction
Cells, 2019 Dietary restriction (DR), which is defined as a reduction of particular or total nutrient intake without causing malnutrition, has been proved to be a robust way to extend both lifespan and health-span in various species from yeast to mammal.
Yizhou Jiang +4 more
doaj +2 more sources
Forkhead Box Transcription Factors: Double-Edged Swords in Cancer
Cancer Research, 2022 A plethora of treatment options exist for cancer therapeutics, but many are limited by side effects and either intrinsic or acquired resistance.
Maria Castaneda +2 more
semanticscholar +3 more sources
Genome-wide binding studies reveal DNA binding specificity mechanisms and functional interplay amongst Forkhead transcription factors [PDF]
Nucleic Acids Res, 2015 Transcription factors belonging to the same transcription factor families contain very similar DNA binding domains and hence have the potential to bind to related DNA sequences.
Xi Chen +3 more
semanticscholar +2 more sources
Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics
Cells, 2019 FOXO transcription factors regulate cellular homeostasis, longevity and response to stress. FOXO1 (also known as FKHR) is a key regulator of hepatic glucose production and lipid metabolism, and its specific inhibition may have beneficial effects on ...
Katarina Psenakova +5 more
doaj +2 more sources
Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance [PDF]
Chin J Cancer, 2013 The FOXO3a and FOXM1 forkhead transcription factors are key players in cancer initiation, progression, and drug resistance. Recent research shows that FOXM1 is a direct transcriptional target of FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO ...
A. Gomes, F. Zhao, E. Lam
semanticscholar +2 more sources
Hierarchical Interactions of Homeodomain and Forkhead Transcription Factors in Regulating Odontogenic Gene Expression [PDF]
Journal of Biological Chemistry, 2011 FoxJ1 is a forkhead transcription factor expressed in multiple tissues during development and a major regulator of cilia development. FoxJ1−/− mice present with defects in odontogenesis, and we correlate these defects to hierarchical interactions between
Shankar Rengasamy Venugopalan +7 more
openalex +2 more sources
Understanding the perspectives of forkhead transcription factors in delayed wound healing [PDF]
J Cell Commun Signal, 2018 N. K. Rajendran +3 more
semanticscholar +2 more sources