Results 11 to 20 of about 143 (143)
Cancer Reports, EarlyView., 2023 Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada +16 more
wiley +1 more source
Forkhead transcription factors in chronic inflammation [PDF]
The International Journal of Biochemistry & Cell Biology, 2010 Forkhead (Fox) transcription factors have been increasingly recognized to play key roles in immune homeostasis, especially Foxp3 for its role in the development and function of regulatory T cells, and Foxo family members for their regulatory role in T and B lymphocytes as well as other leukocytes.
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Negative Regulation of the Forkhead Transcription Factor FKHR by Akt [PDF]
Journal of Biological Chemistry, 1999 The FKHR gene was first identified from its disruption by the t(2;13) chromosomal translocation seen in the pediatric tumor alveolar rhabdomyosarcoma. It encodes for a member of the forkhead family of transcription factors. Recently, a homolog of FKHR in the nematode Caenorhabditis elegans was identified called DAF-16, which is a downstream target of ...
Gabriel Núñez +3 more
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Deciphering the Role of Forkhead Transcription Factors in Cancer Therapy [PDF]
Current Drug Targets, 2011 Forkhead O transcription factors (FOXO) are critical for the regulation of cell cycle arrest, cell death, and DNA damage repair. Inactivation of FOXO proteins may be associated with tumorigenesis, including breast cancer, prostate cancer, glioblastoma, rhabdomyosarcoma, and leukemia. Accumulated evidence shows that activation of oncogenic pathways such
Mien Chie Hung, Jer Yen Yang
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Ocular forkhead transcription factors: seeing eye to eye [PDF]
The International Journal of Developmental Biology, 2009 Forkhead transcription factors comprise a large family of proteins with diverse functions during development. Recently, there has been accumulating evidence that several members of this family of proteins play an important role in the development of the vertebrate retina.
Heithem M. El-Hodiri +3 more
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The forkhead transcription factor Foxc2 stimulates osteoblast differentiation
Bone, 2009 The forkhead box C2 (Foxc2) protein is a member of the family of winged helix/forkhead transcription factors. Foxc2-deficient mice display defective formation of the aortic arches, multiple craniofacial bones, and vertebral columns. To investigate the role of Foxc2 in osteoblast differentiation, DNA containing Foxc2 was transfected into the developing ...
Lim, SK +6 more
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Transcriptional Activation of Placental Growth Factor by the Forkhead/Winged Helix Transcription Factor FoxD1 [PDF]
Current Biology, 2003 Stromal-epithelial interactions play an important role in renal organogenesis. Expression of the forkhead/winged helix transcription factor FoxD1 (BF-2) is restricted to stromal cells in the embryonic renal cortex, but it mediates its effects on the adjacent ureteric bud and metanephric mesenchyme, which fail to grow and differentiate in BF-2 null mice.
Roderick V. Jensen +9 more
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The Forkhead Transcription Factor Foxo1 [PDF]
Molecular Cell, 2003 The forkhead transcription factor Foxo1 has previously been shown to be a mediator of insulin action in liver and pancreas. New data from demonstrate that it also functions in adipose cells to couple insulin signaling to adipogenesis, which involves switching preadipocytes from proliferation to terminal differentiation.
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CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Forkhead-associated Domains of the Tobacco NtFHA1 Transcription Activator and the Yeast Fhl1 Forkhead Transcription Factor Are Functionally Conserved [PDF]
Journal of Biological Chemistry, 2002 NtFHA1 encodes a novel protein containing the forkhead-associated (FHA) domain and the acidic domain in Nicotiana tabacum. NtFHA1 functions as a transactivator and is targeted to the nucleus. The sequence of the FHA domain of NtFHA1 is significantly homologous to that of the Fhl1 forkhead transcription factor of yeast. FHL1 was previously identified as
Moonil Kim +4 more
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