Results 21 to 30 of about 56,919 (302)
Mammalian SIRT1 Represses Forkhead Transcription Factors [PDF]
Cell, 2004 The NAD-dependent deacetylase SIR2 and the forkhead transcription factor DAF-16 regulate lifespan in model organisms, such as yeast and C. elegans. Here we show that the mammalian SIR2 ortholog SIRT1 deacetylates and represses the activity of the forkhead transcription factor Foxo3a and other mammalian forkhead factors. This regulation appears to be in
Motta, M. C. +8 more
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Forkhead transcription factors: new considerations for alzheimer's disease and dementia. [PDF]
J Transl Sci, 2016 Life expectancy of individuals in both developed and undeveloped nations continues to rise at an unprecedented rate. Coupled to this increase in longevity for individuals is the rise in the incidence of chronic neurodegenerative disorders that includes Alzheimer's disease (AD).
Maiese K.
europepmc +4 more sources
The forkhead transcription factor FoxY regulates Nanos [PDF]
Molecular Reproduction and Development, 2012 AbstractFoxY is a member of the forkhead transcription factor family that appeared enriched in the presumptive germ line of sea urchins (Ransick et al. Dev Biol 2002;246:132). Here, we test the hypothesis that FoxY is involved in germ line determination in this animal.
Jia L. Song, Gary M. Wessel
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The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation [PDF]
Developmental Cell, 2003 An outstanding question in adipocyte biology is how hormonal cues are relayed to the nucleus to activate the transcriptional program that promotes adipogenesis. The forkhead transcription factor Foxo1 is regulated by insulin via Akt-dependent phosphorylation and nuclear exclusion.
William H. Biggs +5 more
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Role of forkhead transcription factors in diabetes-induced oxidative stress. [PDF]
Exp Diabetes Res, 2012 Diabetes is a chronic metabolic disorder, characterized by hyperglycemia resulting from insulin deficiency and/or insulin resistance. Recent evidence suggests that high levels of reactive oxygen species (ROS) and subsequent oxidative stress are key contributors in the development of diabetic complications.
Ponugoti B, Dong G, Graves DT.
europepmc +6 more sources
DNA-binding specificity changes in the evolution of forkhead transcription factors. [PDF]
Proc Natl Acad Sci U S A, 2013 The evolution of transcriptional regulatory networks entails the expansion and diversification of transcription factor (TF) families. The forkhead family of TFs, defined by a highly conserved winged helix DNA-binding domain (DBD), has diverged into dozens of subfamilies in animals, fungi, and related protists.
Nakagawa S +4 more
europepmc +6 more sources
Molecular Cancer, 2019 Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide and the fourth most frequent cause of death having an oncological origin. It has been found that transcription factors (TF) dysregulation, leading to the significant expression
Paul Laissue
doaj +1 more source
Cell Regeneration, 2021 Forkhead box (Fox) transcription factors play important roles in mammalian development and disease. However, their function in mouse somatic cell reprogramming remains unclear.
Meijun Fu +15 more
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Unveiling Forkhead-mediated regulation of yeast cell cycle and metabolic networks
Computational and Structural Biotechnology Journal, 2022 Transcription factors are regulators of the cell’s genomic landscape. By switching single genes or entire molecular pathways on or off, transcription factors modulate the precise timing of their activation.
Matteo Barberis, Thierry D.G.A. Mondeel
doaj
The mutations and potential targets of the forkhead transcription factor FOXL2 [PDF]
Molecular and Cellular Endocrinology, 2007 Mutations of FOXL2, a gene encoding a forkhead transcription factor, have been shown to cause the blepharophimosis-ptosis-epicanthus inversus syndrome (BPES). This genetic disorder is characterized by eyelid and mild craniofacial abnormalities that can appear associated with premature ovarian failure. FOXL2 is one of the earliest ovarian markers and it
Lara Moumné +6 more
openalex +4 more sources