Results 31 to 40 of about 94,681 (279)

Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction

Cells, 2019
Dietary restriction (DR), which is defined as a reduction of particular or total nutrient intake without causing malnutrition, has been proved to be a robust way to extend both lifespan and health-span in various species from yeast to mammal.
Yizhou Jiang, Fengxia Yan, Zhongping Feng, Philip Lazarovici, Wenhua Zheng   +4 more
doaj   +1 more source

The Role of Polo-Like Kinase 1 in Regulating the Forkhead Box Family Transcription Factors

Cells, 2023
Polo-like kinase 1 (PLK1) is a serine/threonine kinase with more than 600 phosphorylation substrates through which it regulates many biological processes, including mitosis, apoptosis, metabolism, RNA processing, vesicle transport, and G2 DNA-damage ...
Xavier T. R. Moore, Lilia Gheghiani, Zheng Fu   +2 more
doaj   +1 more source

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. [PDF]

, 2015
The current knowledge on how transcription factors (TFs), the ultimate targets and executors of cellular signalling pathways, are regulated by protein-protein interactions remains limited.
Anna Malovannaya, David H Hawke, Jiadong Wang, Jun Qin, Junjie Chen, Kaestner KH, Rudy Guerra, Wei Li, Wenqi Wang, Xu Li, Yuanxin Xi   +10 more
core   +2 more sources

Acupuncture and cellular mechanisms: the role of foxo transcription factors in autophagy and senescence

Journal of the Pakistan Medical Association
The current narrative review was planned to elucidate the interplay between acupuncture, a cornerstone of Traditional Chinese Medicine, and the modulation of cellular mechanisms via Forkhead box O transcription factors, focussing on autophagy and ...
Lizhi Zhou, Xuying Li, Jinbi Ao, Na Duan
doaj   +1 more source

Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: Expression and Function of Forkhead Transcription Factors in Neurons

Journal of Pharmacological Sciences, 2005
Forkhead box transcription factor, class O (FOXO) is a mammalian homologue of DAF-16, which is known to regulate the lifespan of Caenorhabditis elegans and includes subfamilies of forkhead transcription factors such as AFX, FKHRL1, and FKHR.
Kohji Fukunaga, Takao Ishigami, Takayuki Kawano   +2 more
doaj   +1 more source

MS-Based Approaches Enable the Structural Characterization of Transcription Factor/DNA Response Element Complex

Biomolecules, 2019
The limited information available on the structure of complexes involving transcription factors and cognate DNA response elements represents a major obstacle in the quest to understand their mechanism of action at the molecular level.
Lukáš Slavata, Josef Chmelík, Daniel Kavan, Růžena Filandrová, Jan Fiala, Michal Rosůlek, Hynek Mrázek, Zdeněk Kukačka, Karel Vališ, Petr Man, Michael Miller, William McIntyre, Daniele Fabris, Petr Novák   +13 more
doaj   +1 more source

Quantitative model of eukaryotic Cdk control through the Forkhead CONTROLLER

npj Systems Biology and Applications, 2021
In budding yeast, synchronization of waves of mitotic cyclins that activate the Cdk1 kinase occur through Forkhead transcription factors. These molecules act as controllers of their sequential order and may account for the separation in time of ...
Matteo Barberis
doaj   +1 more source

Forkhead transcription factors in the regulation of VEGF in breast cancer

, 2011
High levels of the major angiogenic factor VEGF, have been reported in a number of cancer cell lines and in clinical specimens derived from breast.
Karadedou, Christina Theano, Karadedou, Christina Theano   +1 more
core   +1 more source

Regulation of Ace2-dependent genes requires components of the PBF complex in schizosaccharomyces pombe [PDF]

, 2015
The division cycle of unicellular yeasts is completed with the activation of a cell separation program that results in the dissolution of the septum assembled during cytokinesis between the 2 daughter cells, allowing them to become independent entities ...
Alonso-Nuñez, María Luisa, del Rey, Francisco, McInerny, Christopher J., Suárez, M Belén, Vázquez de Aldana, Carlos R   +4 more
core   +1 more source

Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics

Cells, 2019
FOXO transcription factors regulate cellular homeostasis, longevity and response to stress. FOXO1 (also known as FKHR) is a key regulator of hepatic glucose production and lipid metabolism, and its specific inhibition may have beneficial effects on ...
Katarina Psenakova, Klara Kohoutova, Veronika Obsilova, Michael J. Ausserlechner, Vaclav Veverka, Tomas Obsil   +5 more
doaj   +1 more source