Results 31 to 40 of about 626,933 (316)
Phylogenetic analysis of forkhead transcription factors in the Panarthropoda. [PDF]
Dev Genes Evol, 2022 AbstractFox genes encode transcription factors that contain a DNA binding domain, the forkhead domain, and are known from diverse animal species. The exact homology of the Fox genes of different species is debated and this makes inferences about the evolution of the Fox genes, and their duplications and losses difficult.
Schomburg C, Janssen R, Prpic NM.
europepmc +5 more sources
The Forkhead Transcription Factor Foxo1 [PDF]
Molecular Cell, 2003 Stephen R. Farmer
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Deciphering the role of forkhead transcription factors in cancer therapy. [PDF]
Curr Drug Targets, 2011 Jer-Yen Yang, M. Hung
semanticscholar +2 more sources
Unveiling Forkhead-mediated regulation of yeast cell cycle and metabolic networks
Computational and Structural Biotechnology Journal, 2022 Transcription factors are regulators of the cell’s genomic landscape. By switching single genes or entire molecular pathways on or off, transcription factors modulate the precise timing of their activation.
Matteo Barberis, Thierry D.G.A. Mondeel
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Forkhead transcription factors in chronic inflammation. [PDF]
Int J Biochem Cell Biol, 2010 Forkhead (Fox) transcription factors have been increasingly recognized to play key roles in immune homeostasis, especially Foxp3 for its role in the development and function of regulatory T cells, and Foxo family members for their regulatory role in T and B lymphocytes as well as other leukocytes.
Peng SL.
europepmc +4 more sources
Forkhead transcription factors and ageing [PDF]
Oncogene, 2008 Mutations in single genes and environmental interventions can extend healthy lifespan in laboratory model organisms. Some of the mechanisms involved show evolutionary conservation, opening the way to using simpler invertebrates to understand human ageing.
L, Partridge, J C, Brüning
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The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. [PDF]
PLoS Biology, 2007 Parkinson disease affects more than 1% of the population over 60 y old. The dominant models for Parkinson disease are based on the use of chemical toxins to kill dopamine neurons, but do not address the risk factors that normally increase with age ...
Raja Kittappa +3 more
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npj Systems Biology and Applications, 2021 Networks of interacting molecules organize topology, amount, and timing of biological functions. Systems biology concepts required to pin down ‘network motifs’ or ‘design principles’ for time-dependent processes have been developed for the cell division ...
Matteo Barberis
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Involvement of the JNK/FOXO3a/Bim Pathway in Neuronal Apoptosis after Hypoxic-Ischemic Brain Damage in Neonatal Rats. [PDF]
, 2015 c-Jun N-terminal kinase (JNK) plays a key role in the regulation of neuronal apoptosis. Previous studies have revealed that forkhead transcription factor (FOXO3a) is a critical effector of JNK-mediated tumor suppression.
Li, Deyuan +8 more
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FoxP4, a novel forkhead transcription factor [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2003 Forkhead proteins have been demonstrated to play key roles in embryonic development, cell cycle regulation, and oncogenesis. We report the characterization of a new forkhead transcription factor, which is a member of the FoxP subfamily. In adult tissues FoxP4 is expressed in heart, brain, lung, liver, kidney, and testis. By Northern hybridization, very
Andreas, Teufel +4 more
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