Results 31 to 40 of about 56,919 (302)
The Vitamin Nicotinamide: Translating Nutrition into Clinical Care
Molecules, 2009 Nicotinamide, the amide form of vitamin B3 (niacin), is changed to its mononucleotide compound with the enzyme nicotinic acide/nicotinamide adenylyltransferase, and participates in the cellular energy metabolism that directly impacts normal physiology ...
Zhao Zhong Chong +3 more
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Negative Regulation of the Forkhead Transcription Factor FKHR by Akt [PDF]
Journal of Biological Chemistry, 1999 The FKHR gene was first identified from its disruption by the t(2;13) chromosomal translocation seen in the pediatric tumor alveolar rhabdomyosarcoma. It encodes for a member of the forkhead family of transcription factors. Recently, a homolog of FKHR in the nematode Caenorhabditis elegans was identified called DAF-16, which is a downstream target of ...
Gabriel Núñez +3 more
openaire +3 more sources
Ocular forkhead transcription factors: seeing eye to eye [PDF]
The International Journal of Developmental Biology, 2009 Forkhead transcription factors comprise a large family of proteins with diverse functions during development. Recently, there has been accumulating evidence that several members of this family of proteins play an important role in the development of the vertebrate retina.
Heithem M. El-Hodiri +3 more
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FoxO Proteins in the Nervous System
Analytical Cellular Pathology, 2015 Acute as well as chronic disorders of the nervous system lead to significant morbidity and mortality for millions of individuals globally. Given the ability to govern stem cell proliferation and differentiated cell survival, mammalian forkhead ...
Kenneth Maiese
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The Role of Polo-Like Kinase 1 in Regulating the Forkhead Box Family Transcription Factors
Cells, 2023 Polo-like kinase 1 (PLK1) is a serine/threonine kinase with more than 600 phosphorylation substrates through which it regulates many biological processes, including mitosis, apoptosis, metabolism, RNA processing, vesicle transport, and G2 DNA-damage ...
Xavier T. R. Moore +2 more
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Cancer Reports, EarlyView., 2023 Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada +16 more
wiley +1 more source
Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction
Cells, 2019 Dietary restriction (DR), which is defined as a reduction of particular or total nutrient intake without causing malnutrition, has been proved to be a robust way to extend both lifespan and health-span in various species from yeast to mammal.
Yizhou Jiang +4 more
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Quantitative model of eukaryotic Cdk control through the Forkhead CONTROLLER
npj Systems Biology and Applications, 2021 In budding yeast, synchronization of waves of mitotic cyclins that activate the Cdk1 kinase occur through Forkhead transcription factors. These molecules act as controllers of their sequential order and may account for the separation in time of ...
Matteo Barberis
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Targeting the core of neurodegeneration: FoxO, mTOR, and SIRT1
Neural Regeneration Research, 2021 The global increase in lifespan noted not only in developed nations, but also in large developing countries parallels an observed increase in a significant number of non-communicable diseases, most notable neurodegenerative disorders.
Kenneth Maiese
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Journal of the Pakistan Medical AssociationThe current narrative review was planned to elucidate the interplay between acupuncture, a cornerstone of Traditional Chinese Medicine, and the modulation of cellular mechanisms via Forkhead box O transcription factors, focussing on autophagy and ...
Lizhi Zhou, Xuying Li, Jinbi Ao, Na Duan
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