Results 41 to 50 of about 216,058 (206)
Journal of Internal Medicine, Volume 293, Issue 1, Page 4-22, January 2023., 2023 Abstract The kidneys, by equilibrating the outputs to the inputs, are essential for maintaining the constant volume, pH, and electrolyte composition of the internal milieu. Inability to do so, either because of internal kidney dysfunction (primary alteration) or because of some external factors (secondary alteration), leads to pathologies of varying ...
Nahid Tabibzadeh, Gilles Crambert
wiley +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Cancer Communications, EarlyView.Abstract Background Tumor‐associated neutrophils (TANs) play a critical role in modulating immune responses and exhibit significant heterogeneity. Our previous study demonstrated that jagged canonical Notch ligand 2 (JAG2)+ TANs were associated with an immunosuppressive microenvironment in high‐grade serous ovarian cancer (HGSOC), but the underlying ...
Chenyang Wang +11 more
wiley +1 more source
Negative Example Aided Transcription Factor Binding Site Search [PDF]
arXiv, 2011 Computational approaches to transcription factor binding site identification have been actively researched for the past decade. Negative examples have long been utilized in de novo motif discovery and have been shown useful in transcription factor binding site search as well.
arxiv
The link of FOXO1 and FOXO4 transcription factors to development of the lens
Developmental Dynamics, EarlyView.Abstract Background The FOXOs regulate the transcription of many genes, including ones directly linked to pathways required for lens development. However, this transcription factor family has rarely been studied in the context of development, including the development of the lens.
Rifah N. Gheyas +3 more
wiley +1 more source
Exploration, EarlyView.This study investigated the role of the βB2‐crystallin c.562C>T (p.R188C) mutation in congenital cataract. Clinical pedigree analysis, combined with whole‐exome sequencing (WES), identified this pathogenic variant. Bioinformatic analyses predicted destabilization of the mutant protein’s tertiary structure, potentially impairing its function.
Yibo Yu +14 more
wiley +1 more source
DNA binding specificity of all four Saccharomyces cerevisiae forkhead transcription factors. [PDF]
Nucleic Acids Res, 2023 Cooper BH +4 more
europepmc +1 more source
Transcription-driven genome organization: a model for chromosome structure and the regulation of gene expression tested through simulations [PDF]
Nucleic Acids Res. 46, 9895 (2018), 2020 Current models for the folding of the human genome see a hierarchy stretching down from chromosome territories, through A/B compartments and TADs (topologically-associating domains), to contact domains stabilized by cohesin and CTCF. However, molecular mechanisms underlying this folding, and the way folding affects transcriptional activity, remain ...
arxiv
Navigating the treatment landscape of Alzheimer's disease: Current strategies and future directions
Ibrain, EarlyView.Alzheimer's disease treatment is evolving rapidly, with emerging strategies targeting multiple disease pathways. This graphical abstract highlights the shift from traditional therapies to innovative approaches that hold promise for improving outcomes.
Tapas Kumar Mohapatra +4 more
wiley +1 more source
Phylogenetic analysis of forkhead transcription factors in the Panarthropoda. [PDF]
Dev Genes Evol, 2022 Schomburg C, Janssen R, Prpic NM.
europepmc +1 more source