Results 21 to 30 of about 13,165 (247)

Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2

Viruses, 2021
Herpes simplex viruses-1 and -2 (HSV-1 and -2) are two of the three human alphaherpesviruses that cause infections worldwide. Since both viruses can be acquired in the absence of visible signs and symptoms, yet still result in lifelong infection, it is ...
Lauren A. Sadowski, Rista Upadhyay, Zachary W. Greeley, Barry J. Margulies   +3 more
doaj   +1 more source

Continuous-Infusion Foscarnet Facilitates Administration in Hematopoietic Stem Cell Transplantation Patients.

Transplantation and Cellular Therapy, 2021
Infections due to herpesviruses resistant to first-line antivirals remains an ever-present and serious complication in recipients of hematopoietic cell transplantation (HCT) and other cellular therapies.
Walter Domingo, I. Nguyen, Joyce J. Johnsrud, J. Brown   +3 more
semanticscholar   +1 more source

At-Home Foscarnet Administration in Patients with Cytomegalovirus Infection Post-Allogeneic Stem Cell Transplantation: A Unicentric, Safe, and Feasible Program

Pharmaceuticals, 2023
Cytomegalovirus (CMV) infection is a relevant cause of morbimortality in patients receiving allogeneic stem cell transplantation (allo-HCT). Foscarnet (FCN) is an effective drug against CMV administered intravenously and usually on an inpatient basis ...
Sonia Ruiz-Boy, Alexandra Pedraza, Marta Prat, Maria Queralt Salas, Esther Carcelero, Gisela Riu-Viladoms, María Suárez-Lledó, Inés Monge-Escartín, Luis Gerardo Rodríguez-Lobato, Alexandra Martínez-Roca, Montserrat Rovira, Carmen Martínez, Cristina Gallego, Álvaro Urbano-Ispizua, Joan Sánchez, María Ángeles Marcos, Francesc Fernández-Avilés   +16 more
doaj   +1 more source

Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet. [PDF]

ACS Chemical Biology, 2016
HIV-1 reverse transcriptase (RT) catalytically incorporates individual nucleotides into a viral DNA strand complementing an RNA or DNA template strand; the polymerase active site of RT adopts multiple conformational and structural states while performing
K. Das, J. Balzarini, Matthew T. Miller, A. Maguire, J. DeStefano, E. Arnold   +5 more
semanticscholar   +4 more sources

Preparation, characterization and in vitro antiviral activity evaluation of foscarnet-chitosan nanoparticles

Colloids and Surfaces B: Biointerfaces, 2014
Noemi Gaglianone, Sara Baldassari
exaly   +2 more sources

Kyrieleis Arteriolitis Associated with Acute Retinal Necrosis Due to Herpes Simplex Virus Type 1 Secondary to Herpetic Encephalitis

Vision, 2022
We report the case of a 52-year-old woman who presented to the emergency department with acute retinal necrosis in her left eye secondary to herpes simplex virus type 1 encephalitis for which she had been hospitalized four months before.
Olga E. Makri, Iasonas K. Tsekouras, Leonidia Leonidou, Konstantinos Kagkelaris, Vassilios Kozobolis, Constantinos D. Georgakopoulos   +5 more
doaj   +1 more source

Validated Modernized Assay for Foscarnet in Pharmaceutical Formulations Using Suppressed Ion Chromatography Developed through a Quality by Design Approach

Separations, 2021
Inspired by the United States Pharmacopoeia (USP) “monograph modernization” initiative, we developed and validated an assay for foscarnet sodium injection solution (“foscavir”), following quality by design (QbD) principles, incorporating design of ...
Ngoc Phuoc Dinh, Adel Shamshir, Gjani Hulaj, Tobias Jonsson   +3 more
doaj   +1 more source

Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy

Current Hematologic Malignancy Reports, 2020
Purpose of Review CMV DNA polymerase inhibitors such as ganciclovir and foscarnet have dramatically reduced the burden of CMV infection in the HCT recipient. However, their use is often limited by toxicities and resistance.
M. Hakki
semanticscholar   +1 more source

Prophylactic foscarnet for human herpesvirus 6: effect on hematopoietic engraftment after reduced intensity conditioning umbilical cord blood transplantation.

Biology of Blood and Marrow Transplantation, 2020
High incidence of human herpesvirus-6 (HHV-6) reactivation, potentially interfering with engraftment after umbilical cord blood (UCB) hematopoietic cell transplantation (HCT), remains a major challenge.
Najla El Jurdi, J. Rogosheske, T. Defor, N. Bejanyan, M. Arora, V. Bachanova, B. Betts, Fiona He, S. Holtan, Murali Janakiram, Samantha Larson, J. Maakaron, A. Rashidi, E. Warlick, J. Wagner, Jo-Anne H. Young, D. Weisdorf, C. Brunstein   +17 more
semanticscholar   +1 more source

Unraveling Cytomegalovirus Drug Resistance in Transplant Patients by Targeting Deep Sequencing. [PDF]

J Med Virol
ABSTRACT Drug‐resistant cytomegalovirus (CMV) poses a major clinical challenge in transplant recipients, leading to treatment failure and increased morbidity. This study applied a next‐generation sequencing (NGS) approach to identify antiviral resistance mutations (ARMs) in 71 samples from 68 CMV‐positive patients who had undergone hematopoietic stem ...
Alemán S, Camacho J, Recio V, Ruiz E, Zamarrón P, Anel J, Enjuto M, Tarragó D.   +7 more
europepmc   +2 more sources