Results 1 to 10 of about 159,335 (341)

Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer [PDF]

, 2013
Background: Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also
A Ho-Pun-Cheung, A Merlo, Ana Maria Waaga-Gasser, Andreas Rosenwald, C Loddenkemper, Christoph-Thomas Germer, E Sato, Eva Meier, F Ichihara, FA Sinicrope, FL Greene, H Groux, H Lu, H Suzuki, H Tao, HL Weiner, Igor Tsaur, J Shimizu, JD Fontenot, Jun Li, LM Ebert, M Viguier, Maria Lazariotou, Martin Gasser, Martin Grimm, ME Winerdal, Mia Kim, MJ Sack, N Chaput, N Hiraoka, N Kobayashi, P Correale, P Salama, P Yu, Roman Blaheta, S Hinz, S Ladoire, S Onizuka, T Alvaro, Tanja Grimmig, TL Whiteside, Uwe Heemann, V Karanikas, W Zou, WH Wang, WS Lee   +45 more
core   +21 more sources

Immunomodulatory Effect of Propolis on Foxp3 Gene Expression in Human Peripheral Blood Mononuclear Cells Stimulated in vitro with Pseudomonas Aeruginosa Ag [PDF]

Archives of Razi Institute, 2021
Immune balance during infection is critical for both supporting the defense of the immune system of the body and preventing an overly aggressive immune response.
F. A Alwaeely, K. N Madlum, M. A Alsaadi
doaj   +1 more source

Upregulation of Cytotoxic T-Lymphocyte-Associated Protein 4 and Forkhead Box P3 Transcripts in Peripheral Blood of Patients with Bladder Cancer [PDF]

Iranian Journal of Medical Sciences, 2021
Background: Regulatory T cells (Tregs) play a key role in the progression of tumors. These cells express forkhead box P3 (FOXP3) and cytotoxic T-lymphocyte-associated protein 4 (CTLA4), which are the potential targets for cancer immunotherapy.
Ali Ariafar, Mojtaba Habibagahi, Mansooreh Jaberipour, Abdolaziz Khezri, Mohammad Hadi Khezri, Hale Bozorgi, Ahmad Hosseini, Mahboobeh Razmkhah   +7 more
doaj   +1 more source

Characterization of human epithelial resident memory regulatory T cells

Frontiers in Immunology, 2022
Human resident memory regulatory T cells (Tregs) exist in the normal, noninflamed skin. Except one, all previous studies analyzed skin Tregs using full-thickness human skin.
Takuya Sato, Youichi Ogawa, Kazunori Yokoi, Yuka Nagasaka, Aoha Ishikawa, Ichiro Shiokawa, Manao Kinoshita, Rei Watanabe, Shinji Shimada, Atsushi Tanaka, Akira Momosawa, Tatsuyoshi Kawamura   +11 more
doaj   +1 more source

Foxp3: Shades of Tolerance [PDF]

Immunity, 2012
In this issue of Immunity, Darce et al. (2012) and Bettini et al. (2012) demonstrate that seemingly subtle alterations in the interaction of Foxp3 with its transcriptional partners have a ripple effect on the outcome of autoimmune phenotypes, worsening some while ameliorating others.
Calvin B. Williams, Talal A. Chatila
openaire   +3 more sources

Promiscuous Foxp3‐cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells [PDF]

Immunology & Cell Biology, 2014
Costimulatory signals by CD28 are critical for thymic regulatory T‐cell (Treg) development. To determine the functional relevance of CD28 for peripheral Treg post thymic selection, we crossed the widely used Forkhead box protein 3 (Foxp3)‐CreYFP mice to mice bearing a conditional Cd28 allele.
Dean Franckaert, Susan M. Schlenner, Evelyne Roos, Hervé Luche, Hervé Luche, Hervé Luche, Jochen Huehn, James Dooley, Michelle A. Linterman, Hans Joerg Fehling, Adrian Liston, Stefan Floess   +11 more
openaire   +4 more sources

FOXP3 expression in FOXP3+ tumor cells promotes hepatocellular cells metastasis [PDF]

Translational Cancer Research, 2020
Forkhead transcription factor 3 (FOXP3) is a key molecule for the development of regulatory T cell. Recent studies showed that FOXP3 was also expressed in tumor cells. This study is designed to identify the expression of FOXP3 and its pathogenesis in hepatocellular carcinoma (HCC).Through immunohistochemistry, RNA extraction and Real-Time Quantitative ...
Lai Wei, Ran Fei, Ming-hui Mei, Yanhui Chen, Weijia Liao, Xingwang Xie, Li Wang, Henghui Zhang, Xueyan Wang, Hongsong Chen   +9 more
openaire   +3 more sources

Prediction of response to surgical therapy in nonsegmental vitiligo based on an immunohistochemical cutoff value

Journal of the Egyptian Women’s Dermatologic Society, 2020
Background Objective assessment of stability is still lacking in nonsegmental vitiligo (NSV). Objective To suggest immunohistochemical cutoff values that can predict a good response to surgical therapy of NSV cases.
Dalia A Bassiouny, Samar El Tahlawy, Amira El Tawdy, Mostafa Abdellatif, Doaa Ibrahim Eldesouky Amin   +4 more
doaj   +1 more source

The adaptability of regulatory T cells and Foxp3 [PDF]

International Immunology, 2021
Abstract Regulatory T (Treg) cells that express the lineage-defining transcription factor Foxp3 play a pivotal role in establishing and maintaining immune and tissue homeostasis. Foxp3 serves as a highly connected ‘hub’, interacting with numerous genomic sites and partner proteins, in the molecular network that orchestrates multiple ...
Shohei Hori, Ryuichi Murakami
openaire   +3 more sources

Regulatory T cells (Tregs) and their therapeutic potential against autoimmune disorders – Advances and challenges

Human Vaccines & Immunotherapeutics, 2022
Autoimmune diseases are caused when immune cells act against self-protein. This biological self–non-self-discrimination phenomenon is controlled by a distinct group of lymphocytes known as regulatory T cells (Tregs), which are key inflammatory response ...
Tapas Kumar Goswami, Mithilesh Singh, Manish Dhawan, Saikat Mitra, Talha Bin Emran, Ali A. Rabaan, Abbas Al Mutair, Zainab Al Alawi, Saad Alhumaid, Kuldeep Dhama   +9 more
doaj   +1 more source