Immunomodulatory Effect of Propolis on Foxp3 Gene Expression in Human Peripheral Blood Mononuclear Cells Stimulated in vitro with Pseudomonas Aeruginosa Ag [PDF]
Archives of Razi Institute, 2021 Immune balance during infection is critical for both supporting the defense of the immune system of the body and preventing an overly aggressive immune response.
F. A Alwaeely, K. N Madlum, M. A Alsaadi
doaj +1 more source
Upregulation of Cytotoxic T-Lymphocyte-Associated Protein 4 and Forkhead Box P3 Transcripts in Peripheral Blood of Patients with Bladder Cancer [PDF]
Iranian Journal of Medical Sciences, 2021 Background: Regulatory T cells (Tregs) play a key role in the progression of tumors. These cells express forkhead box P3 (FOXP3) and cytotoxic T-lymphocyte-associated protein 4 (CTLA4), which are the potential targets for cancer immunotherapy.
Ali Ariafar +7 more
doaj +1 more source
FOXP3 expression in FOXP3+ tumor cells promotes hepatocellular cells metastasis [PDF]
Translational Cancer Research, 2020 Forkhead transcription factor 3 (FOXP3) is a key molecule for the development of regulatory T cell. Recent studies showed that FOXP3 was also expressed in tumor cells. This study is designed to identify the expression of FOXP3 and its pathogenesis in hepatocellular carcinoma (HCC).Through immunohistochemistry, RNA extraction and Real-Time Quantitative ...
Zhang, Henghui +9 more
openaire +2 more sources
Human Vaccines & Immunotherapeutics, 2022 Autoimmune diseases are caused when immune cells act against self-protein. This biological self–non-self-discrimination phenomenon is controlled by a distinct group of lymphocytes known as regulatory T cells (Tregs), which are key inflammatory response ...
Tapas Kumar Goswami +9 more
doaj +1 more source
Characterization of human epithelial resident memory regulatory T cells
Frontiers in Immunology, 2022 Human resident memory regulatory T cells (Tregs) exist in the normal, noninflamed skin. Except one, all previous studies analyzed skin Tregs using full-thickness human skin.
Takuya Sato +11 more
doaj +1 more source
Expression levels of MIF, NLRP1 and FOXP3 genes along with biomarker levels in patients with active form of non-segmental generalized vitiligo: A study in South Indian population [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2022 Vitiligo, the most widespread hypopigmentary syndrome, is considered to be a multifactorial disease in which the active melanocytes are lost. Vitiligo has been studied in a variety of ways, and several genes have been implicated.
Alokananda Chakraborty +10 more
doaj +1 more source
The role of regulatory T cells in autoimmune thyroiditis
Медицинский совет, 2021 Autoimmune thyroiditis is an organ-specific autoimmune disease caused by the activation of self-reactive CD4+ T cells. Regulatory T (Treg) cells are a population of T cells that play a central role in immunological tolerance by suppressing selfreactive ...
S. I. Zhukova +4 more
doaj +1 more source
Prospective validation of CD4 CD25 FOXP3 T-regulatory cells as an immunological marker to differentiate intestinal tuberculosis from Crohn’s disease [PDF]
Intestinal Research, 2021 Background/Aims Crohn’s disease (CD) and intestinal tuberculosis (ITB) remain “difficult-to-differentiate” diseases. We have previously documented peripheral blood frequency of CD4+ CD25+ FOXP3+ T-regulatory cells (Treg) as a biomarker to differentiate ...
Ritika Rampal +9 more
doaj +1 more source
FOXP3 Gene Variants in Patients with Systemic Lupus Erythematosus: Association with Disease Susceptibility in Men and Relationship with Abortion in Women [PDF]
Iranian Journal of Immunology, 2022 Background: FOXP3, an important transcription factor of regulatory T cells has shown a contribution to the development of various autoimmune diseases. Objectives: To investigate the influence of FOXP3 polymorphisms (rs3761548 and rs2294021) on systemic ...
Paria Heydarinezhad +4 more
doaj +1 more source
Foxp3: Shades of Tolerance [PDF]
Immunity, 2012 In this issue of Immunity, Darce et al. (2012) and Bettini et al. (2012) demonstrate that seemingly subtle alterations in the interaction of Foxp3 with its transcriptional partners have a ripple effect on the outcome of autoimmune phenotypes, worsening some while ameliorating others.
Chatila, Talal A., Williams, Calvin B.
openaire +2 more sources