Results 131 to 140 of about 159,335 (341)

Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer [PDF]

, 2016
Tregs can contribute to tumor progression by suppressing antitumor immunity. Exceptionally, in human colorectal cancer (CRC), Tregs are thought to exert beneficial roles in controlling pro-tumor chronic inflammation.
BARNABA, Vincenzo, CARONNA, Roberto, CHIRLETTI, Piero, CIARDI, Antonio, DEL BENE, GABRIELLA, FARELLI, FRANCESCO, Focaccetti, Chiara, Longo, Flavia, MORELLI, Sergio, PACELLA, ILENIA, PICONESE, SILVIA, SACCO, LUCA, SCHINZARI, VALERIA, TIMPERI, ELEONORA, VESTRI, Anna Rita   +14 more
core   +1 more source

Transcription Factor Assay of Peripheral Blood T cells in Different Groups of Rheumatoid Arthritis Patients

Research in Molecular Medicine, 2020
Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints and other tissues and organs of the body.
Saeid Taghiloo, Abolghasem Ajami, Mohsen Tehrani, Arezou Abbasi, Reza Alizadeh-Navaei, Mohsen Akhiani, Alireza Salami   +6 more
doaj  

Engineered Probiotics Mitigate Gut Barrier Dysfunction Induced by Nanoplastics

Advanced Science, EarlyView.
Intestinal barrier stability is vital for gut health. Plastic polyethylene terephthalate (PET) disrupts this barrier, causing inflammation and infections. This study encodes transforming growth factor‐β into EcN and modifies its surface with pH‐responsive polymer (EcNT@L), creating an oral drug delivery system to repair nano PET‐induced intestinal ...
Wenxin Chen, Qiyan Guo, Hong Li, Xue Chi, Xiang Ma, Yanqiong Tang, Quanfeng Liang, Zhu Liu, Yong Liu, Juanjuan Li   +9 more
wiley   +1 more source

Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression. [PDF]

, 2007
The impact of regulatory T cells (T reg cells) on the course of HIV and SIV disease is unknown. T reg cells could suppress protective antiviral responses and accelerate disease progression.
Abel, Kristina, Hartigan-O'Connor, Dennis J, McCune, Joseph M   +2 more
core   +2 more sources

DL-propargylglycine administration inhibits TET2 and FOXP3 expression and alleviates symptoms of neonatal Cows’ milk allergy in mouse model

Autoimmunity, 2020
Background Cows’ milk allergy (CMA) is a hypersensitivity immune reaction brought on by specific immunologic mechanisms to cow’s milk proteins. As one of the most common food allergies in infants, the incidence of CMA during the first year of life is ...
Beibei Sun, Dongjin Feng, Guangmeng Wang, Xiaohong Yu, Zhongmao Dong, Ling Gao   +5 more
doaj   +1 more source

Chimeric Nanozyme Bacterial Outer Membrane Vesicles Reprograming Tumor Microenvironment for Safe and Efficient Anticancer Therapy

Advanced Science, EarlyView.
This study reports an innovative strategy to improve the safety of OMVs by shielding them with a sophisticated shell composed of DaFe shell and Au nanoparticles, which not only reduces the toxicity of OMVs during circulation but also enables rapid release of these therapeutically active components in tumor for combined therapy involving glucose ...
Fan Zhang, Qianqian Li, Haibing Dai, Weiqun Li, Xiang Chen, Huibin Wu, Shanming Lu, Ran Luo, Feng Li, Guihong Lu, Jianbo Yu, Lin Mei   +11 more
wiley   +1 more source

Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX) [PDF]

, 2001
Ichiro Kobayashi, Reza Shiari, Masafumi Yamada, Nobuaki Kawamura, Motohiko Okano, Asao Yara, Akihiro Iguchi, Nobuyoshi Ishikawa, Tadashi Ariga, Yukio Sakiyama, Hans D. Ochs, Kunihiko Kobayashi   +11 more
openalex   +1 more source

IFN-γ-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain.

, 2012
It is well established that IFN-γ is required for the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice. However, the temporal and tissue-specific cellular sources of IFN-γ during P.
Blount, Daniel G, Couper, Kevin N, de Souza, J Brian, Greig, Rachel, Gwyer Findlay, Emily, Hafalla, Julius CR, Hunter, Christopher A, Riley, Eleanor M, Shaw, Tovah N, Stumhofer, Jason S, Villegas-Mendez, Ana   +10 more
core   +1 more source

An AI based Digital Score of Tumour-Immune Microenvironment Predicts Benefit to Maintenance Immunotherapy in Advanced Oesophagogastric Adenocarcinoma [PDF]

arXiv
Gastric and oesophageal (OG) cancers are the leading causes of cancer mortality worldwide. In OG cancers, recent studies have showed that PDL1 immune checkpoint inhibitors (ICI) in combination with chemotherapy improves patient survival. However, our understanding of the tumour immune microenvironment in OG cancers remains limited.
arxiv  

Targeting Antigen‐Presenting Cells to Enhance the Tumor‐Spleen Immunity Cycle through Liposome‐Neoantigen Vaccine

Advanced Science, EarlyView.
LNPsD18, a cationic liposome that enhances antigen‐presenting cell uptake in the spleen and tumor without targeting ligands is developed. Co‐delivering neoantigens and a TLR9 agonist significantly improve DC activation, tumor immunity, and survival in liver and colorectal cancer models, demonstrating the importance of dual‐site APC targeting for cancer
Yu Xu, Bing Wang, Yue Huang, JianPing Liao, Chenyi Wu, Chenxi Zhou, Zishi Kang, Shiyang Jiang, Bing‐Chen Wu, Da Zhang, Ruihua Xu, Xiaolong Liu, Feng Wang   +12 more
wiley   +1 more source