Results 131 to 140 of about 106,447 (316)

Inulin‐Based Oral Chemotherapy Modulates Gut Microbiota and Immune Microenvironment through Inhibition of Neutrophil Extracellular Trap Formation for Improving Cancer Therapy

Advanced Science, EarlyView.
Schematic representation of ZIF‐8@OXA@inulin for cancer immunotherapy. Synthesis of ZIF‐8@OXA@inulin. Augmentation of pyroptosis, regulation of gut microbiota, and inhibition of NETs formation by ZIF‐8@OXA@inulin‐mediated comprehensive strategy for antitumor immune response. ABSTRACT Despite the potential of chemoimmunotherapy against colorectal cancer
Zhenhao Li, Jiaqiang Jiang, Yuping Zhou, Xinyuan Mao, Haotian Wen, Zhian Chen, Yutong Wang, Cong Huang, Yanfeng Hu   +8 more
wiley   +1 more source

A novel FOXP3 knockout-humanized mouse model for pre-clinical safety and efficacy evaluation of Treg-like cell products [PDF]

Yohei Sato, Abinaya Nathan, Suzette Shipp, J. Fraser Wright, Keri Tate, Prachi Wani, Maria‐Grazia Roncarolo, Rosa Bacchetta   +7 more
openalex   +1 more source

CD169+ Macrophage‐Targeted Immunomodulator to Restore Phagocytic Function and Enhance Antigen Presentation for Lymphatic Metastasis Eradication

Advanced Science, EarlyView.
A CD169+ macrophage‐targeted immunomodulator (G‐LNP@S‐D) is developed to co‐deliver a SHP2 inhibitor and STING agonist, thereby restoring phagocytic function, enhancing antigen presentation by CD169+ macrophages, and promoting T cell priming to eradicate lymphatic metastasis.
Xiayun Chen, Lichong Lu, Yibin Liu, Ziqi Liang, Jianqiao Li, Zhouchuan Shao, Youzhi Tang, Jianhua Zou, Shiying Li, Xiaoyuan Chen   +9 more
wiley   +1 more source

Do all Foxp3+ Tregs require Foxp3 for suppression?

American Journal of Transplantation, 2022
openaire   +2 more sources

CD39/ENTPD1 Expression by CD4+Foxp3+ Regulatory T Cells Promotes Hepatic Metastatic Tumor Growth in Mice [PDF]

, 2010
Xiaofeng Sun, Yan Wu, Wenda Gao, Keiichi Enjyoji, Eva Csizmadia, Christa E. Müller, Takashi Murakami, Simon C. Robson   +7 more
openalex   +1 more source

Mitochondrial Transcription Factor A Regulates Foxp3+ T Cell Mediated Maintenance of CD4+ T Cell Landscapes and Immunological Aging [PDF]

, 2022
Kai Guo, Zhihan Wang, Trishna Debnath, Het Mehta, Eden Abrham, Zachery Even, Mansib Rahman, Abby Lund Da Costa, Shilpi Jain, Xusheng Wang, Junguk Hur, Gopal Murugaiyan, Adrian T. Ting, Holly M. Brown‐Borg, Donald A. Jurivich, Nadeem A. Khan, Ramkumar Mathur   +16 more
openalex   +1 more source

Irradiated Tumor Cell‐Derived Microparticles Activate Systemic Anti‐Tumor Immunity via the STING/NLRP3/GSDMD Axis in Neutrophils

Advanced Science, EarlyView.
Radiotherapy induces tumor cells to release microparticles (RT‐MPs) into the circulation. The mitochondrial DNA carried by these RT‐MPs activates the STING/NLRP3/GSDMD axis in splenic neutrophils, triggering IL‐1β secretion. This, in turn, enhances dendritic cell function and facilitates the formation of cytotoxic T lymphocytes, thereby promoting ...
Yan Hu, Jiacheng Wang, Mengjie Che, Zheng Yang, Jingshu Meng, Xiao Yang, Yue Deng, Zhiyuan Zhou, Yijun Wang, Wenwen Wei, Zhanjie Zhang, Bian Wu, You Qin, Kunyu Yang, Honglin Jin, Fang Huang, Yajie Sun, Lu Wen, Chao Wan   +18 more
wiley   +1 more source

New approach in Understanding Colorectal Cancer Immunosuppression and Immunotherapy-Based Strategies in the Treatment of Microsatellite Stable Colorectal Cancer

Acta Medica Bulgarica
Except the widely accepted use of immune Checkpoint inhibitors in the treatment of microsatellite instability-high (MSI-H) mismatch repair-deficient (MMRd) CRCs representing about 5% of all metastatic (m)CRC patients, new strategies are applied to cure ...
Gulubova M., Chonov D., Ignatova M. M., Yovchev Y.   +3 more
doaj   +1 more source

Crying Time and RORγ/FOXP3 Expression in Lactobacillus reuteri DSM17938-Treated Infants with Colic: A Randomized Trial [PDF]

, 2017
Francesco Savino, María Garro, Paola Montanari, Ilaria Galliano, Massimiliano Bergallo   +4 more
openalex   +1 more source

Joint Public Review: Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function

, 2023
Rajan M. Thomas, Matthew C. Pahl, Liqing Wang, Struan F.A. Grant, Wayne W. Hancock, Andrew D. Wells   +5 more
openalex   +1 more source