Results 11 to 20 of about 167,256 (310)

FOXP3 expression in FOXP3+ tumor cells promotes hepatocellular cells metastasis [PDF]

Translational Cancer Research, 2020
Forkhead transcription factor 3 (FOXP3) is a key molecule for the development of regulatory T cell. Recent studies showed that FOXP3 was also expressed in tumor cells. This study is designed to identify the expression of FOXP3 and its pathogenesis in hepatocellular carcinoma (HCC).Through immunohistochemistry, RNA extraction and Real-Time Quantitative ...
Zhang, Henghui, Chen, Yanhui, Liao, Weijia, Wang, Li, Xie, Xingwang, Fei, Ran, Wang, Xueyan, Mei, Minghui, Wei, Lai, Chen, Hongsong   +9 more
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Foxp3: Shades of Tolerance [PDF]

Immunity, 2012
In this issue of Immunity, Darce et al. (2012) and Bettini et al. (2012) demonstrate that seemingly subtle alterations in the interaction of Foxp3 with its transcriptional partners have a ripple effect on the outcome of autoimmune phenotypes, worsening some while ameliorating others.
Chatila, Talal A., Williams, Calvin B.
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FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing [PDF]

, 2018
FOXP3 promotes the development and function of regulatory T cells mainly through regulating the transcription of target genes. RNA alternative splicing has been implicated in a wide range of physiological and pathophysiological processes.
Du, Jianguang, Wang, Qun, Zhou, Baohua, Ziegler, Steven F.   +3 more
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Human FOXP3 and cancer [PDF]

Oncogene, 2010
FOXP3 is a transcription factor necessary and sufficient for induction of the immunosuppressive functions in regulatory T lymphocytes. Its expression was first considered as specific of this cell type, but FOXP3 can also be transiently expressed in T-cell antigen receptor-activated human nonregulatory T cells.
F, Martin, S, Ladoire, G, Mignot, L, Apetoh, F, Ghiringhelli   +4 more
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Regulatory T cells (Tregs) and their therapeutic potential against autoimmune disorders – Advances and challenges

Human Vaccines & Immunotherapeutics, 2022
Autoimmune diseases are caused when immune cells act against self-protein. This biological self–non-self-discrimination phenomenon is controlled by a distinct group of lymphocytes known as regulatory T cells (Tregs), which are key inflammatory response ...
Tapas Kumar Goswami, Mithilesh Singh, Manish Dhawan, Saikat Mitra, Talha Bin Emran, Ali A. Rabaan, Abbas Al Mutair, Zainab Al Alawi, Saad Alhumaid, Kuldeep Dhama   +9 more
doaj   +1 more source

Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation [PDF]

, 2020
Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive
Drovakova A., Giallongo S., Li Volti G., Lo Re O., Mazza T., Rappa F., Roskams T., Sanna P., Tsochatzis E., Van Haele M., Vinciguerra M., Vinh Luong T.   +11 more
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Promiscuous Foxp3‐cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells [PDF]

Immunology & Cell Biology, 2014
Costimulatory signals by CD28 are critical for thymic regulatory T‐cell (Treg) development. To determine the functional relevance of CD28 for peripheral Treg post thymic selection, we crossed the widely used Forkhead box protein 3 (Foxp3)‐CreYFP mice to mice bearing a conditional Cd28 allele.
Franckaert, Dean, Dooley, James, Roos, Evelyne, Floess, Stefan, Huehn, Jochen, Luche, Herve, Fehling, Hans Joerg, Liston, Adrian, Linterman, Michelle A., Schlenner, Susan   +9 more
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NATURAL REGULATORY T CELLS AND THEIR MOLECULAR MARKER FOXP3 IN FREQUENTLY ILL PRE-SCHOOL CHILDREN LIVING IN AREAS WITH HUMAN-INDUCED IMPACT

Педиатрическая фармакология, 2013
The study presents the review of recent literature on microbial resistance in children suffered from reccurent respiratory infaction (RRI). Special aspects of immune system in children with allergy and acute respiratory infection are discussed. We report
A. D. Pertseva, N. Z. Zokirov, V. V. Troshina, L. S. Namazova-Baranova, S. Y. Tarakanova   +4 more
doaj   +1 more source

CD3+CD4+LAP+Foxp3-regulatory cells of the colonic lamina propria limit disease extension in ulcerative colitis [PDF]

, 2018
Background and Aims: In ulcerative colitis (UC), inflammation begins in the rectum and can extend proximally throughout the entire colon. The extension of inflammation is an important determinant of disease course, and may be limited by the action of ...
Amendola, Antonello, Boirivant, Monica, Borrini, Francesco, Butera, Alessia, De Nitto, Daniela, Di Carlo, Nazzareno, Frasca, Loredana, Lande, Roberto, Pica, Roberta, Pronio, Annamaria, Sanchez, Massimo   +10 more
core   +3 more sources

FOXP3-specific immunity [PDF]

OncoImmunology, 2013
Forkhead box P3 (FOXP3)-specific cytotoxic CD8+ T cells are present among human peripheral blood mononuclear cells (PBMCs), especially in cancer patients. Such T lymphocytes are able not only to specifically recognize dendritic cells (DCs) that have been exposed to recombinant FOXP3 and regulatory T cells, but also to kill FOXP3+ malignant T cells. The
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