Results 271 to 280 of about 167,256 (310)
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Nature Immunology, 2017
By switching its partners, FoxP3 segregates into functional and non-functional transcriptional complexes.
David Bending, Masahiro Ono
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By switching its partners, FoxP3 segregates into functional and non-functional transcriptional complexes.
David Bending, Masahiro Ono
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Human FOXP3 and tumour microenvironment
Immunology, 2022AbstractThe tumour microenvironment (TME) is a complex system composed of cancer cells, stromal cells and immune cells. Regulatory T cells (Tregs) in the TME impede immune surveillance of tumours and suppress antitumor immune responses. Transcription factor forkhead box protein 3 (FOXP3) is the main marker of Tregs, which dominates the function of ...
Jia Wang +5 more
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Annals of the New York Academy of Sciences, 2008
Tolerance to self antigens is established in two ways: first in the thymus through the deletion of thymocytes expressing self‐reactive T cell receptors; and second, in the periphery through multiple mechanisms involving deletion, anergy, and suppression.
Jane H, Buckner, Steven F, Ziegler
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Tolerance to self antigens is established in two ways: first in the thymus through the deletion of thymocytes expressing self‐reactive T cell receptors; and second, in the periphery through multiple mechanisms involving deletion, anergy, and suppression.
Jane H, Buckner, Steven F, Ziegler
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FOXP3+ regulatory T cells: control of FOXP3 expression by pharmacological agents
Trends in Pharmacological Sciences, 2011Naturally arising CD4(+)CD25(+) regulatory T cells (Tregs), which specifically express the forkhead family transcription factor FOXP3, are essential for the maintenance of immunological self-tolerance and immune homeostasis. Tregs can suppress the activation, proliferation and effector function of other lymphocytes in physiological and pathological ...
Naganari, Ohkura +2 more
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Suppression by human FOXP3 + regulatory T cells requires FOXP3-TIP60 interactions
Science Immunology, 2017Targeting the FOXP3-TIP60 interaction may modulate T reg activity in IPEX and other autoimmune and inflammatory diseases.
Khalid Bin Dhuban +16 more
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Nutrition, 2016
The aim of this study was to identify regulatory T cell (Treg) subsets residing in adipose tissue, demonstrate their immunosuppressive functions, and assess the possible role of Sirt1 in their function in overweight subjects.Fat samples were obtained by lipoaspiration from healthy overweight (n = 15) and normoweight (n = 11) subjects.
Aleida, Núñez Ruiz +9 more
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The aim of this study was to identify regulatory T cell (Treg) subsets residing in adipose tissue, demonstrate their immunosuppressive functions, and assess the possible role of Sirt1 in their function in overweight subjects.Fat samples were obtained by lipoaspiration from healthy overweight (n = 15) and normoweight (n = 11) subjects.
Aleida, Núñez Ruiz +9 more
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FOXP3 gene polymorphisms in preeclampsia
American Journal of Obstetrics and Gynecology, 2012To determine whether polymorphisms in the FOXP3 gene are associated with preeclampsia.Case-control study in which 120 women with preeclampsia were compared with 120 healthy normotensive controls. Genetic variants (single nucleotide polymorphisms and microsatellites) in the FOXP3 gene were analyzed.
Torri D, Metz +3 more
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Analysis of FOXP3 DNA Methylation Patterns to Identify Functional FOXP3+ T-Cell Subpopulations
2022Human regulatory CD4+CD25+FOXP3+ T cells (Tregs) are involved in the suppression of immune responses and play important roles in the maintenance of self-tolerance and immune homeostasis. Abnormal Treg function may result in disease states of varying severity.
Ekaterina, Minskaia, João F, Lacerda
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Nature Immunology, 2008
Inducible regulatory T cells respond to TGF-β by upregulating Foxp3 expression. Tone and colleagues identify an enhancer site in Foxp3 that binds transcription factors Smad3 and NFAT, suggesting a means by which TGF-β regulates Foxp3 expression.
Harald von Boehmer, Jens Nolting
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Inducible regulatory T cells respond to TGF-β by upregulating Foxp3 expression. Tone and colleagues identify an enhancer site in Foxp3 that binds transcription factors Smad3 and NFAT, suggesting a means by which TGF-β regulates Foxp3 expression.
Harald von Boehmer, Jens Nolting
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Annual Review of Immunology, 2006
The immune system has evolved mechanisms to recognize and eliminate threats, as well as to protect against self-destruction. Tolerance to self-antigens is generated through two fundamental mechanisms: (a) elimination of self-reactive cells in the thymus during selection and (b) generation of a variety of peripheral regulatory cells to control self ...
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The immune system has evolved mechanisms to recognize and eliminate threats, as well as to protect against self-destruction. Tolerance to self-antigens is generated through two fundamental mechanisms: (a) elimination of self-reactive cells in the thymus during selection and (b) generation of a variety of peripheral regulatory cells to control self ...
openaire +2 more sources