Results 51 to 60 of about 106,447 (316)

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Immunohistochemistry method and diagnostics of mycosis fungoides

Vestnik Dermatologii i Venerologii, 2017
Clinical patient examinations are not enough for diagnosing lymphoproliferative skin diseases now. Histological diagnostics is an important auxiliary method; however, it is not always applicable.
A. S. Zhukov, I. E. Belousova, A. V. Samtsov   +2 more
doaj   +1 more source

FOXP3 (forkhead box P3) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on FOXP3 (forkhead box P3), with data on DNA, on the protein encoded, and where the gene is implicated.
Liu, Y, Wang, L
openaire   +2 more sources

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Association study of FOXP3 gene and the risk of 0020 pre-eclampsia

Clinical and Experimental Hypertension, 2018
Pre-eclampsia (PE) is a multifactorial pregnancy disorder, with serious consequences for both the mother and the fetus. Despite intense studies, the pathophysiology of PE remains enigmatic.
Milad Gholami, Reza Mirfakhraie, Reihaneh Pirjani, Robabeh Taheripanah, Sahar Bayat, Seyyedeh Anita Daryabari, Matina Noori, Sayyed Mohamad Hossein Ghaderian   +7 more
doaj   +1 more source

Cryptotanshinone possesses therapeutic effects on ischaemic stroke through regulating STAT5 in a rat model

Pharmaceutical Biology, 2021
Context Cryptotanshinone (CT), a lipophilic compound extracted from roots of Salvia miltiorrhiza Bunge (Lamiaceae) (Danshen), has multiple properties in diseases, such as pulmonary fibrosis, lung cancer, and osteoarthritis.
Feihong Zhu, Hehe Chen, Meifei Xu, Xiajun Zhang, Jing Yu, Yali Pan, Weixin Zhu   +6 more
doaj   +1 more source

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

IL‐2 Free Expansion of T Cells with Immunofilaments

Advanced Healthcare Materials, EarlyView.
Ratio and density of stimulatory αCD3 and αCD28 mAb on immunofilaments (IF) influence T cell expansion, cytokine production, and effector phenotype. Moreover, IL‐2 supplementation is not necessary with optimal performing IFs, which leads to simpler culture conditions, and negative side effects of IL‐2 supplementation are reduced.
Marjolein Schluck, Lea Weiss, René Classens, Carl G. Figdor, Roel Hammink   +4 more
wiley   +1 more source

FOXP3

RCSB Protein Data Bank
Citation: 'Foxp3' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13141 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +2 more sources

Unraveling T-cell dynamics using fluorescent timer: Insights from the Tocky system

Biophysics and Physicobiology
Understanding the temporal dynamics of T-cell transcription is crucial for insights into immune cell function and development. In this study, we show the features of the Timer-of-Cell-Kinetics-and-Activity (Tocky) system, which enables analysis of ...
Masahiro Ono
doaj   +1 more source