Results 71 to 80 of about 4,329 (161)

Spatial omics for profiling the dynamic tumor microenvironment

Clinical &Translational Immunology, Volume 15, Issue 4, 2026.
Spatially resolved transcriptomics and proteomics map RNA/protein in intact tumor tissues, revealing crucial cancer–immune interactions across the different stages of tumor evolution. Integrating AI promises translational impact, but gaps in cross‐platform integration, standards, compute, validation and interpretability remain.
Hao Nguyen, Merrin Mary Eapen, Quan Nguyen, Ankur Sharma   +3 more
wiley   +1 more source

Jiawei Danxuan Koukang and Its Component Kaempferol Alleviate Oral Submucous Fibrosis by Restoring Epithelial‐Fibroblast Homeostasis and Suppressing Neutrophil Recruitment via the ANXA1/FPR2 Axis

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
JDK and kaempferol upregulate ANXA1 in oral epithelia, which bind to fibroblast FPR2 to suppress myofibroblast activation, and collagen deposition, while reducing neutrophil recruitment and inflammation, thereby restoring epithelial‐fibroblast homeostasis to alleviate arecoline‐induced OSF. ABSTRACT Oral submucous fibrosis (OSF) is a betel quid chewing‐
Yao Xiao, Yisi Tan, Yanli Liu, Ruiyi Chen, Tao Zhou, Zhaoyong Hu, Jin Tan   +6 more
wiley   +1 more source

Single‐Cell Profiling Reveals Distinct Immune Communication Networks in Centenarians and Elderly Controls

Aging Cell, Volume 25, Issue 4, April 2026.
Single‐cell profiling of PBMCs from centenarians, their offspring, and elderly controls revealed distinct myeloid‐to‐effector immune cell communication programs. General aging was characterized by SASP‐enriched signaling associated with immunosenescence, whereas healthy aging showed positive immune regulatory signaling associated with enhanced ...
Liwei Qiu, Chen Dong, Rui Zhao, Huiyuan Ye, Jian‐lin Gao, Yizhi Chen, Chi Sun, Zhifeng Gu   +7 more
wiley   +1 more source

Differential requirement of formyl peptide receptor 1 in macrophages and neutrophils in the host defense against Mycobacterium tuberculosis Infection

Scientific Reports
Formyl peptide receptors (FPR), part of the G-protein coupled receptor superfamily, are pivotal in directing phagocyte migration towards chemotactic signals from bacteria and host tissues.
Tanvir Noor Nafiz, Poornima Sankar, Lokesh K. Mishra, Robert P. Rousseau, Mohd Saqib, Selvakumar Subbian, Suraj P. Parihar, Bibhuti B. Mishra   +7 more
doaj   +1 more source

Formyl Peptide Receptor 1 and 2 Dual Agonist Inhibits Human Neutrophil Chemotaxis by the Induction of Chemoattractant Receptor Cross-desensitization

Journal of Pharmacological Sciences, 2011
Formyl peptide receptor 1 (FPR1) and FPR2/ALX are known to control neutrophil chemotaxis in response to various ligands. In this study, we investigated the inhibitory mechanism of compound 43 (Cpd43), an FPR1 and FPR2/ALX dual agonist, on human ...
Yoshitaka Sogawa, Takao Ohyama, Hiroaki Maeda, Kazuki Hirahara   +3 more
doaj   +1 more source

FPR1 does not mediate neutrophil infiltration in experimental colitis

The FASEB Journal, 2009
One hallmark of the inflammatory bowel diseases is the infiltration of neutrophils (PMN) into the mucosa. The mechanism behind this infiltration is unclear but bacterial N‐formyl peptides are candidates since these are potent chemoattractants and activating factors for PMN.
Andrew William Stadnyk, Shukkur M. Farooq   +1 more
openaire   +1 more source

The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Alzheimer's disease (AD) and glioblastoma multiforme (GBM) are biologically distinct age‐related brain disorders with opposing clinical phenotypes. AD is characterised by progressive neurodegeneration and cognitive decline, whereas GBM is characterised by aggressive cellular proliferation and a poor prognosis.
Ana B. Caniceiro, Sofia P. Agostinho, Luiz F. Piochi, Nícia Rosário‐Ferreira, Irina S. Moreira   +4 more
wiley   +1 more source

Formyl peptide receptor 1 up-regulation and formyl peptide receptor 2/3 down-regulation of blood immune cells along with defective lipoxin A4/resolvin D1 production in obstructive sleep apnea patients.

PLoS ONE, 2019
BACKGROUND:This study aims to investigate the role of FPR 1/2/3 expressions in patients with obstructive sleep apnea (OSA). METHOD:We made cross-sectional comparisons of FPR1/2/3 expressions of blood neutrophil, M1/M2a monocyte, and natural killer (NK ...
Yung-Che Chen, Mao-Chang Su, Chien-Hung Chin, I-Chun Lin, Po-Yuan Hsu, Chia-Wei Liou, Kuo-Tung Huang, Ting-Ya Wang, Yong-Yong Lin, Yi-Xin Zheng, Chang-Chun Hsiao, Meng-Chih Lin   +11 more
doaj   +1 more source

Retro-inverso Urokinase Receptor Antagonists for the Treatment of Metastatic Sarcomas

Scientific Reports, 2017
The development of metastases is a multistep process that requires the activation of physiological and biochemical processes that govern migration, invasion and entry of metastatic cells into blood vessels.
Maria Vincenza Carriero, Katia Bifulco, Vincenzo Ingangi, Susan Costantini, Giovanni Botti, Concetta Ragone, Michele Minopoli, Maria Letizia Motti, Domenica Rea, Giosuè Scognamiglio, Gerardo Botti, Claudio Arra, Gennaro Ciliberto, Antonello Pessi   +13 more
doaj   +1 more source

Increased expression of formyl peptide receptor-1 by basophils from patients with mastocytosis

Journal of Allergy and Clinical Immunology: Global
Background: Symptoms in patients with systemic mastocytosis (SM) are associated with an increase in mast cell burden and release of mast cell–derived mediators.
Yuzhi Yin, MD, PhD, Jenny Min Li, PhD, Dean D. Metcalfe, MD, Ana Olivera, PhD, Pamela A. Frischmeyer-Guerrerio, MD, PhD, Melody C. Carter, MD, Hirsh Komarow, MD   +6 more
doaj   +1 more source