Results 61 to 70 of about 1,208 (179)

The circulating cell-free DNA landscape in sepsis is dominated by impaired liver clearance

Cell Genomics
Summary: Circulating cell-free DNA (cfDNA) is a promising molecular biomarker, but its role in severe infection is unclear. Here, we profile cfDNA from sepsis patients and controls, demonstrating a 41-fold increase during disease.
Kiki Cano-Gamez, Patrick Maclean, Masato Inoue, Sakineh Hussainy, Elisabeth Foss, Chloe Wainwright, Hanyu Qin, Stuart McKechnie, Chun-Xiao Song, Julian C. Knight   +9 more
doaj   +1 more source

Pancreatic Cancer Early Detection Biomarkers for High‐Risk Individuals: Insights From the PRECEDE Consortium

International Journal of Cancer, Volume 159, Issue 8, Page 1873-1883, 15 October 2026.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to its asymptomatic progression, late‐stage diagnosis, and treatment resistance. Efforts in early detection have centered on identifying imaging features and liquid biopsy biomarkers capable of detecting PDAC and its high‐grade precursors before clinical symptoms ...
Christine Worthington, Maria Raitses‐Gurevich, Giulio Innamorati, Phil A. Hart, Thomas M. Wilkie, Noam Tau, Dana Brin, Doron Yablecovitch, Ido Laish, Dove Keith, Kurt Giles, Jennifer B. Permuth, Diane M. Simeone, George Zogopoulos, Randall E. Brand, John J. Graff, Julie Earl, On behalf of the PRECEDE Consortium, Nikhil Agarwal, Laufey Amundadottir, Michelle Anderson, Ajay Bansal, Todd Bauer, Georg Beyer, Yan Bi, Erkut Borazanci, Randy Brand, Teri Brentnall, Carol Burke, Darren Carpizo, Saurabh Chawla, Daniel Chung, Sourat Darabi, Michael Demeure, Timothy Donahue, Julie Earl, Whitney Espinel, James Farrell, Vigdís Fjóla Stefánsdóttir, Jared Forrester, Eitan Friedman, Paul Franklin, Srinivas Gaddam, Ana García García de Paredes, Steven Gallinger, Talia Golan, Ora Gordon, Robert Grant, William Greenhalf, Eli Marie Grindedal, Aaron Grossberg, Brenda Hafers, Heather Hannon, Sigurdís Haraldsdóttir, Stefán Haraldsson, Peter Hegyi, Melissa Hogg, Amy de Haar‐Holleman, Susan Hong, Greg Idos, Edward Kim, Fay Kastrinos, Bryson Katona, Vivek Kaul, Derk Klatte, Kelsey Klute, Kimberly Ku, Sonia Kupfer, Rich Kwon, Rosario Ligresti, James James Lin, Wei‐Chih (David) Liao, Aimee Lucas, Nipun Merchant, Andrew Metz, Whitney Maxwell, James McLoughlin, Sodech Miclette, Xavier Molero, Leticia Moreira, Takuji Okusaka Chigusa Morizane, Joanne Ngeow, Salvatore Paiella, Jennifer Permuth, Maricel Purcell, Joshua Raff, Vineet Rolston, Intan Schrader, Rosie Sears, Yan‐Shen Shan, Diane Simeone, Jens Siveke, Brett Sheppard, Tyler Stevens, Elena Stoffel, Dan Sussman, Margaret Tempero, Jose Trevino, Jennifer Valerin, Eva Vaquero, Ray Wadlow, Garrett Ward, David Weinberg, Ronald Wolf, Dana Zakalik, George Zogopoulos   +105 more
wiley   +1 more source

First-trimester non-invasive prediction of preterm birth using cell-free DNA fragmentomics

AJOG Global Reports
: Background: Spontaneous preterm birth (PTB) remains a leading cause of neonatal morbidity and mortality, yet accurate prediction in asymptomatic women during early gestation remains a critical unmet clinical need. Cell-free DNA (cfDNA) obtained through
My-Diem Nguyen Pham, MSc, Minh-Tam Thi Phan, MSc, Nhat-Thang Tran, MD, PhD, Ta-Son Vo, MD, Hong-Thinh Le, MD, Thu-Ha Thi Nguyen, MD, Quoc-Huy Vu Nguyen, MD, PhD, Minh-Thi Thi Ha, MD, PhD, Tam Minh Le, MD, PhD, Diem-Tuyet Thi Hoang, MD, PhD, Khanh-Trang Nguyen Huynh, MD, PhD, Nhan Viet Nguyen, MD, PhD, Chuong Canh Nguyen, MD, Thuong Chi Bui, MD, PhD, Xuan Thanh Nguyen, MD, Sa Viet Le, MD, PhD, Vinh Dinh Tran, MD, My-Nhi Ba Nguyen, MD, Thong Van Nguyen, MD, Tuyet-Anh Thi Nguyen, MD, Ba Phuoc Hoang, MD, Trong Van Nguyen, MD, Thuy-Ai Thuy Nguyen, MD, Toa Tri Nguyen, MD, Thang Duc Duong, MD, Cuong Huy Pham, MD, Kim-Oanh Thi Luong, MD, Cuong Ngoc Dao, MD, Khanh Van Hoang, MD, Thu-Thanh Thi Huynh, MD, Khuong Manh Nguyen, MD, Son-Tra Thi Tran, MD, Hoanh Trung Tran, MD, Son Canh Nguyen, MD, Thuy Dinh Tran, MD, Phương Thi Lan Nguyen, MD, Thanh Viet Pham, MD, Kong Chi Pham, MD, PhD, Minh Doan Thai, MD, Thanh-Thuy Thi Do, MD, PhD, Hoa Thi Dao, MD, PhD, Yen-Linh Thi Van, MSc, Sang Hung Tang, MD, Hoai-Nghia Nguyen, PhD, Minh-Duy Phan, PhD, Hoa Giang, PhD, Cuong Thach Nguyen, PhD, Quang Thinh Trac, PhD   +47 more
doaj   +1 more source

Dynamic Predictions in Non‐Small Cell Lung Cancer Using Joint Modeling of Longitudinal and Time‐To‐Event Outcomes Data

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Joint modeling (JM) of longitudinal and time‐to‐event (TTE) data is a powerful statistical technique that elucidates how temporal changes in a biomarker relate to TTE outcomes while accounting for study confounders. The growing use of next‐generation sequencing (NGS) in precision oncology, particularly in capturing circulating tumor DNA (ctDNA)
Christopher R. Pretz, Sara Wienke, Carin R. Espenschied, Samantha I. Liang, Jiemin Liao, Christopher R. Cabanski, Jim Hayes, Victoria Ngo, Enjun Yang, Amar K. Das   +9 more
wiley   +1 more source

Liquid biopsy in genitourinary oncology: Current clinical applications and future prospects across prostate, bladder, and renal cancers

UroPrecision, Volume 4, Issue 3, Page 137-153, September 2026.
Abstract Liquid biopsy has emerged as a transformative approach in oncology, providing minimally invasive access to tumor‐derived biomarkers with applications across diagnosis, prognosis, therapeutic guidance, and disease monitoring. This literature review synthesizes evidence from 125 studies evaluating circulating tumor DNA, circulating tumor cells ...
Kirolos Eskandar
wiley   +1 more source

Cell-Free Mitochondrial DNA in Cell Culture Supernatant: Fragment Size Analysis and FBS Contamination Assessment

DNA
Background/Objectives: Circulating cell-free DNA (cfDNA) consists of genomic DNA (cf-nDNA) and mitochondrial DNA (cf-mtDNA) fragments released from cells primarily through apoptosis and necrosis.
Patrizia Cesare, Sabrina Colafarina, Antonella Bonfigli, Anna Rita Volpe, Massimo Aloisi, Osvaldo Zarivi, Anna Maria Giuseppina Poma   +6 more
doaj   +1 more source

From Tumour to Bloodstream: Advancing PD‐L1 Testing With Liquid Biopsies in Non‐Small Cell Lung Cancer

Cytopathology, Volume 37, Issue 5, Page 438-448, September 2026.
This review explores liquid biopsy as a complementary approach to tissue‐based PD‐L1 assessment in advanced NSCLC treated with immune checkpoint inhibitors. Focusing on circulating tumour cells, extracellular vesicles, and circulating tumour DNA, it summarises current evidence, technical challenges, and future perspectives for personalised ...
R. Leporati, V. Callegari, A. Ancora, M. Palmieri, B. Riccò, E. Cabitza, L. Trudu, K. Di Emidio, C. Chiavelli, A. Eccher, I. Mastrolia, V. Catani, S. Bettelli, G. Guaitoli, M. Dominici, F. Bertolini   +15 more
wiley   +1 more source

Early stage non–small cell lung cancer: Toward a risk‐adaptive paradigm in the era of biologic precision

CA: A Cancer Journal for Clinicians, Volume 76, Issue 5, September/October 2026.
Abstract The clinical landscape of early stage non–small cell lung cancer is at transformative crossroads. Driven by the widespread adoption of low‐dose computed tomography screening, the frequent detection of ground‐glass opacities, and a rising incidence among never‐smokers, the diagnostic center of gravity has shifted toward earlier, potentially ...
Chaoqi Zhang, Xuanyu Gu, Pan Wang, Dongyu Li, Guochao Zhang, Ting Wang, Peng Wu, Wei Rao, Shan Muhammad, Binghua Tan, Yun Che, Mobai Zhu, Qilin Qiao, Fanbo Lai, Bohui Zhao, Kailun Fei, Yue Wu, Zhihui Zhang, Min Dai, Wanqing Chen, Yawei Zhang, Nan Bi, Jie Wang, Jie He   +23 more
wiley   +1 more source

Early detection of malignant and premalignant peripheral nerve tumors using cell-free DNA fragmentomics [PDF]

PURPOSE: Early detection of neurofibromatosis type 1 (NF1)-associated peripheral nerve sheath tumors (PNST) informs clinical decision-making, enabling early definitive treatment and potentially averting deadly outcomes.
Burgic, Sanita, Chrisinger, John S A, et al.,, Hirbe, Angela C, Armstrong, Amy E, Sundby, R Taylor, Srihari, Divya, Weekley, Kara, Chamberlain, Stacey, Jones, Paul A   +9 more
core   +1 more source

First-trimester multi-modal cell-free DNA analysis for prediction of preterm and term preeclampsia

AJOG Global Reports
BACKGROUND: Preeclampsia, which is a leading cause of maternal and perinatal mortality and morbidity, represents a biologically heterogeneous syndrome. First-trimester screening with the Fetal Medicine Foundation (FMF) competing-risks model for preterm ...
Rebecca Ertl, MD, Argyro Syngelaki, PhD, Olga Frank, PhD, Lukas Lüftinger, PhD, Eva Lukáčová, PhD, Casper Lumby, PhD, Adrian Stütz, PhD, Stephan Beisken, PhD, Andreas E. Posch, PhD, Kypros H. Nicolaides, MD   +9 more
doaj   +1 more source