Fragmentomics - Open Access .click

Results 41 to 50 of about 1,208 (179)

Fragmentation patterns and personalized sequencing of cell‐free DNA in urine and plasma of glioma patients

EMBO Molecular Medicine, 2021
Glioma‐derived cell‐free DNA (cfDNA) is challenging to detect using liquid biopsy because quantities in body fluids are low. We determined the glioma‐derived DNA fraction in cerebrospinal fluid (CSF), plasma, and urine samples from patients using ...
Florent Mouliere +20 more
doaj +1 more source

Supplementary Figure S3 from Enhanced Detection of Landmark Minimal Residual Disease in Lung Cancer using Cell-Free DNA Fragmentomics

, 2023
Leave-one-out cross-validation (LOOCV) results of fragmentomics models using different ...
Xue Wu (15004506) +14 more
core +1 more source

Supplementary Figure S2 from Enhanced Detection of Landmark Minimal Residual Disease in Lung Cancer using Cell-Free DNA Fragmentomics

, 2023
Different cross-validation results of Coxnet model using fragmentomics ...
Xue Wu (15004506) +14 more
core +1 more source

Table S1-2 from Enhanced Detection of Landmark Minimal Residual Disease in Lung Cancer using Cell-Free DNA Fragmentomics

, 2023
Supplementary Table S1. Patient demography Supplementary Table S2. Evaluating fragmentomics model performances and ctDNA mutation-based method.
Xue Wu (15004506) +14 more
core +1 more source

Supplementary Figure S4 from Enhanced Detection of Landmark Minimal Residual Disease in Lung Cancer using Cell-Free DNA Fragmentomics

, 2023
Recursive feature elimination with cross-validation of Coxnet model using fragmentomics ...
Xue Wu (15004506) +14 more
core +1 more source

Supplementary Figure S1 from Enhanced Detection of Landmark Minimal Residual Disease in Lung Cancer using Cell-Free DNA Fragmentomics

, 2023
Evaluating longitudinal fragmentomics model prediction and ctDNA ...
Xue Wu (15004506) +14 more
core +1 more source

Detecting Liver Cancer Using Cell-Free DNA Fragmentomes

Cancer Discovery, 2022
Abstract Liver cancer is a major cause of cancer mortality worldwide. Screening individuals at high risk, including those with cirrhosis and viral hepatitis, provides an avenue for improved survival, but current screening methods are inadequate.
Zachariah H. Foda +20 more
openaire +2 more sources

Profiling disease and tissue-specific epigenetic signatures in cell-free DNA

Journal of Laboratory Medicine, 2022
Programmed cell death, accidental cell degradation and active extrusion constantly lead to the release of DNA fragments into human body fluids from virtually all cell and tissue types.
Oberhofer Angela +3 more
doaj +1 more source

Detection and characterization of lung cancer using cell-free DNA fragmentomes [PDF]

Nature Communications, 2021
AbstractNon-invasive approaches for cell-free DNA (cfDNA) assessment provide an opportunity for cancer detection and intervention. Here, we use a machine learning model for detecting tumor-derived cfDNA through genome-wide analyses of cfDNA fragmentation in a prospective study of 365 individuals at risk for lung cancer. We validate the cancer detection
Dimitrios Mathios +37 more
openaire +6 more sources

Fragmentomics of natural peptide structures

Biochemistry (Moscow), 2009
Natural fragmentation of peptide and other chemical structures is well known. They are a significant object of biochemical investigations. In this connection, the bases and determination are given for the notion of the "fragmentome" as a set of all fragments of a single substance, as well as for global fragmentome of all chemical components of living ...
openaire +4 more sources

cell-free dna
liquid biopsy
cfdna

science
cell‐free dna
epigenetics

methylation
hepatocellular carcinoma
early detection