Results 21 to 30 of about 960 (168)

Cell‐free epigenomes enhanced fragmentomics‐based model for early detection of lung cancer

Clinical and Translational Medicine
Background Lung cancer is a leading cause of cancer mortality, highlighting the need for innovative non‐invasive early detection methods. Although cell‐free DNA (cfDNA) analysis shows promise, its sensitivity in early‐stage lung cancer patients remains a
Yadong Wang, Qiang Guo, Zhicheng Huang, Liyang Song, Fei Zhao, Tiantian Gu, Zhe Feng, Haibo Wang, Bowen Li, Daoyun Wang, Bin Zhou, Chao Guo, Yuan Xu, Yang Song, Zhibo Zheng, Zhongxing Bing, Haochen Li, Xiaoqing Yu, Ka Luk Fung, Heqing Xu, Jianhong Shi, Meng Chen, Shuai Hong, Haoxuan Jin, Shiyuan Tong, Sibo Zhu, Chen Zhu, Jinlei Song, Jing Liu, Shanqing Li, Hefei Li, Xueguang Sun, Naixin Liang   +32 more
doaj   +2 more sources

Cell-Free DNA Fragmentomics: The New “Omics” on the Block [PDF]

Clinical Chemistry, 2020
Rossa W K Chiu, Ellen Heitzer, Y M Dennis Lo, Florent Mouliere, Dana W Y Tsui   +4 more
core   +3 more sources

Comprehensive fragmentation of cell-free repetitive DNA for enhanced cancer detection in plasma [PDF]

Frontiers in Cell and Developmental Biology
BackgroundRepetitive elements account for a large proportion of the human genome and undergo alterations during early tumorigenesis. However, the exclusive fragmentation pattern of DNA-derived cell-free repetitive elements (cfREs) remains unclear ...
Mingguang Zhang, Shuohui Dong, Wei Rao, Shiwen Mei, Gang Hu, Ling Liu, Zhen Wang, Jianqiang Tang   +7 more
doaj   +2 more sources

Fragmentomic liquid biopsy enables early breast cancer detection, molecular subtyping and lymph node assessment [PDF]

Nature Communications
Breast cancer remains a leading global health concern in women, while screening is still limited by imaging accessibility and reduced sensitivity in dense breasts.
Yuxuan Zhu, Siwei Zheng, Yinkuan Shao, Jun Zhou, Xidong Gu, Lesang Shen, Xue Li, Wenjia Liu, Wei Xue, Haiqi Lu, Jun Zhou, Jinghua Ding, Haiming Deng, Jiayin Chen, Zhuohang Yu, Yao Yao, Wenjie Xia, Wuzhen Chen, Shanshan Sun, Zheng Wang, Tianyi Qian, Xiuyan Yu, Jian Liu, Yiding Chen, Ziao Lin, Jian Huang, Chao Ni   +26 more
doaj   +2 more sources

A standardized framework for robust fragmentomic feature extraction from cell-free DNA sequencing data [PDF]

Genome Biology
Fragmentomics features of cell-free DNA represent promising non-invasive biomarkers for cancer diagnosis. A lack of systematic evaluation of biases in feature quantification hinders the adoption of such applications.
Haichao Wang, Paulius D. Mennea, Yu Kiu Elkie Chan, Zhao Cheng, Maria C. Neofytou, Arif Anwer Surani, Aadhitthya Vijayaraghavan, Emma-Jane Ditter, Richard Bowers, Matthew D. Eldridge, Dmitry S. Shcherbo, Christopher G. Smith, Florian Markowetz, Wendy N. Cooper, Tommy Kaplan, Nitzan Rosenfeld, Hui Zhao   +16 more
doaj   +4 more sources

Systematic biases in reference-based plasma cell-free DNA fragmentomic profiling

Cell Reports Methods
Plasma cell-free DNA (cfDNA) fragmentation patterns are emerging directions in cancer liquid biopsy with high translational significance. Conventionally, the cfDNA sequencing reads are aligned to a reference genome to extract their fragmentomic features.
Xiaoyi Liu, Mengqi Yang, Dingxue Hu, Yunyun An, Wanqiu Wang, Huizhen Lin, Yuqi Pan, Jia Ju, Kun Sun   +8 more
openaire   +4 more sources

Circulating nuclear DNA structural features, origins, and complete size profile revealed by fragmentomics

JCI Insight, 2021
To unequivocally address their unresolved intimate structures in blood, we scrutinized the size distribution of circulating cell-free DNA (cfDNA) using whole-genome sequencing (WGS) from both double- and single-strand DNA library preparations (DSP and ...
Cynthia Sanchez, Benoit Roch, Thibault Mazard, Philippe Blache, Zahra Al Amir Dache, Brice Pastor, Ekaterina Pisareva, Rita Tanos, Alain R. Thierry   +8 more
doaj   +2 more sources

Epigenetic modifications of cfDNA in liquid biopsy for the cancer care continuum

Biomedical Journal
This review provides a comprehensive overview of the latest advancements in the clinical utility of liquid biopsy, with a particular focus on epigenetic approaches aimed at overcoming challenges in cancer diagnosis and treatment. It begins by elucidating
Jodie Wong, Rohit Muralidhar, Liang Wang, Chiang-Ching Huang   +3 more
doaj   +2 more sources

Early detection of urological tumors based on genomic characteristics of cell-free DNA fragments: a multi-center study [PDF]

npj Precision Oncology
Cell-free DNA (cfDNA) has shown potential in distinguishing cancer patients from healthy individuals. This study investigates cfDNA fragmentomics—fragmentation patterns, end motifs (EDMs), and breakpoint motifs (BPMs)—to develop an early detection method
Huiyong Zhang, Caihong Huang, Chunmeng Wei, Rongbin Zhou, Chengbang Wang, Wenhao Lu, Zuheng Wang, Xiao Li, Shaohua Chen, Dianyu Wang, Jin Ji, Yuexiang Li, Rirong Yang, Junyi Chen, Yanling Hu, Fubo Wang   +15 more
doaj   +2 more sources

Early detection, clinicopathological subtyping, and prognosis prediction for endometrial cancer patients using fragmentomics liquid biopsy assay [PDF]

ESMO Open
H Bao, Wanxiangfu Tang, Misi He
exaly   +2 more sources