Results 31 to 40 of about 1,208 (179)

pyfraglib: An integrated cfDNA fragmentomics platform

Summary: Cell-free DNA (cfDNA) fragmentomics is the analysis of a diverse set of cfDNA fragment features, e.g. fragment length profiles, windowed protection scores, and end motifs. As such it requires software tooling for fragment extraction, statistical
Jessica Schneider, Roland F Schwarz, Sven Borchmann, Daniel Schuette, Laura K Godfrey, Jan-Michel Heger   +5 more
core   +2 more sources

Multidimensional cell-free DNA fragmentomics enables early detection of breast cancer [PDF]

Breast Cancer Research
Background Cell-free DNA (cfDNA) fragmentomics represents a transformative approach for early breast cancer detection, offering significant potential to improve patient survival through timely intervention.
Lixian Yang, Mengyang An, Heng song, Xuan Zhang, Meiqi Wang, Liu Yang, Xinle Wang, Hua Yang, Xinyue Hong, Zhenchuan Song   +9 more
doaj   +2 more sources

A multi-center study for colorectal cancer early detection in high-risk disease patients using cell-free fragmentomics assay

Cancer Cell International
Background Early detection of colorectal cancer (CRC) is crucial for improving patient survival. This innovative multi-center study aims to develop a non-invasive blood-based assay using cell-free DNA (cfDNA) fragmentomics to differentiate CRC from ...
Bing Gu, Zejian Lyu, Ruowei Yang
exaly   +2 more sources

Cell-Free DNA Fragmentation Patterns in a Cancer Cell Line

Diagnostics, 2022
Unique bits of genetic, biological and pathological information occur in differently sized cell-free DNA (cfDNA) populations. This is a significant discovery, but much of the phenomenon remains to be explored. We investigated cfDNA fragmentation patterns
Vida Ungerer, Abel J. Bronkhorst, Carsten Uhlig, Stefan Holdenrieder   +3 more
doaj   +1 more source

Real‐time analysis of the cancer genome and fragmentome from plasma and urine cell‐free DNA using nanopore sequencing

EMBO Molecular Medicine, 2023
Cell‐free DNA (cfDNA) can be isolated and sequenced from blood and/or urine of cancer patients. Conventional short‐read sequencing lacks deployability and speed and can be biased for short cfDNA fragments.
Ymke van der Pol, Normastuti Adhini Tantyo, Nils Evander, Anouk E Hentschel, Birgit MM Wever, Jip Ramaker, Sanne Bootsma, Marieke F Fransen, Kristiaan J Lenos, Louis Vermeulen, Famke L Schneiders, Idris Bahce, Jakko A Nieuwenhuijzen, Renske DM Steenbergen, D Michiel Pegtel, Norbert Moldovan, Florent Mouliere   +16 more
doaj   +1 more source

Combining variant detection and fragment length analysis improves detection of minimal residual disease in postsurgery circulating tumour DNA of stage II–IIIA NSCLC patients

Molecular Oncology, 2022
Stage II–IIIA nonsmall cell lung cancer (NSCLC) patients receive adjuvant chemotherapy after surgery as standard‐of‐care treatment, even though only approximately 5.8% of patients will benefit.
Daan C. L. Vessies, Milou M. F. Schuurbiers, Vincent van derNoort, Irene Schouten, Theodora C. Linders, Mirthe Lanfermeijer, Kalpana L. Ramkisoensing, Koen J. Hartemink, Kim Monkhorst, Michel M. van denHeuvel, Daan van denBroek   +10 more
doaj   +1 more source

At the dawn: cell-free DNA fragmentomics and gene regulation [PDF]

British Journal of Cancer, 2021
AbstractEpigenetic mechanisms play instrumental roles in gene regulation during embryonic development and disease progression. However, it is challenging to non-invasively monitor the dynamics of epigenomes and related gene regulation at inaccessible human tissues, such as tumours, fetuses and transplanted organs.
openaire   +2 more sources

Cell-Free DNA Fragmentation Patterns as Biomarkers for Human Papillomavirus-Related Cancers: A Systematic Review of Methodological Diversity and Diagnostic Performance. [PDF]

Int J Mol Sci
Novel blood biomarkers are crucial for HPV-related cancers to overcome the limitations of imaging and biopsies. This review evaluates the diagnostic performance of circulating cell-free DNA (cfDNA) fragmentomic patterns, distinguishing host-genome ...
Santos F, Silva MS, Caramelo FA, Santana MM, Nobre RJ, Tomaz JMP, Almeida LP, Figueiredo-Dias M.   +7 more
europepmc   +2 more sources

Epigenetic analysis of cell-free DNA by fragmentomic profiling

Proceedings of the National Academy of Sciences, 2022
Cell-free DNA (cfDNA) fragmentation patterns contain important molecular information linked to tissues of origin. We explored the possibility of using fragmentation patterns to predict cytosine-phosphate-guanine (CpG) methylation of cfDNA, obviating the use of bisulfite treatment and associated risks of DNA degradation.
Qing Zhou, Guannan Kang, Peiyong Jiang, Rong Qiao, W. K. Jacky Lam, Stephanie C. Y. Yu, Mary-Jane L. Ma, Lu Ji, Suk Hang Cheng, Wanxia Gai, Wenlei Peng, Huimin Shang, Rebecca W. Y. Chan, Stephen L. Chan, Grace L. H. Wong, Linda T. Hiraki, Stefano Volpi, Vincent W. S. Wong, John Wong, Rossa W. K. Chiu, K. C. Allen Chan, Y. M. Dennis Lo   +21 more
openaire   +2 more sources

Early detection, clinicopathological subtyping, and prognosis prediction for endometrial cancer patients using fragmentomics liquid biopsy assay [PDF]

ESMO Open
Peng He, Wanxiangfu Tang, Misi He
exaly   +2 more sources