Results 91 to 100 of about 354 (112)

Integration of Cell-Free DNA End Motifs and Fragment Lengths Can Identify Active Genes in Liquid Biopsies

Multiple studies have shown that cell-free DNA (cfDNA) from cancer patients differ in both fragment length and fragment end motif (FEM) from healthy individuals, yet there is a lack of understanding of how the two factors combined are associated with ...
Anders Lade Nielsen, Christoffer Trier Maansson, Peter Meldgaard, Louise Skov Thomsen, Boe Sandahl Sorensen   +4 more
core   +1 more source

Revealing Cell‐Free Mitochondrial DNA Breakage Patterns as Novel Biomarkers for Sepsis

Accurate early diagnosis and prognosis of sepsis remain major clinical challenges. This study explores specific plasma cell‐free mitochondrial DNA (cfmtDNA) breakage patterns as potential biomarkers for sepsis.
Zhenchun Luo, Xuxin Tan, Liangming Liu, Jianfeng Huang, Wei Shen, Chenyang Duan, Ruiyan Ma, Zhezhe Cao, He Huang, Xue Zeng, Haitang Liao, Bing Chen, Shuai Hao, Rui Song   +13 more
core   +1 more source

Chasing the code : Advancing Precision Diagnostics through Next Generation Sequencing

Next generation sequencing (NGS) has revolutionized precision diagnostics by enabling high-throughput analysis of nucleic acids. This thesis combines technical validations with innovative applications of NGS across five studies.
Adolfsson, Emma
core   +1 more source

Correspondence to editorial on “Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinoma” [PDF]

Clinical and Molecular Hepatology
Yang Liu, Fan Peng, Siyuan Wang, Jinliang Xing   +3 more
doaj   +1 more source

Cell-Free DNA Fragmentation Patterns as Biomarkers for Human Papillomavirus-Related Cancers: A Systematic Review of Methodological Diversity and Diagnostic Performance

Novel blood biomarkers are crucial for HPV-related cancers to overcome the limitations of imaging and biopsies. This review evaluates the diagnostic performance of circulating cell-free DNA (cfDNA) fragmentomic patterns, distinguishing host-genome ...
Margarida Figueiredo-Dias, Luís P. Almeida, Jorge M. P. Tomaz, Fernanda Santos, Marta S. Silva, Francisco A. Caramelo, Magda M. Santana, Rui J. Nobre   +7 more
core   +1 more source

Author Correction: Quantitative fragmentomics allow affinity mapping of interactomes

Nature Communications, 2022
Gergo Gogl, Boglarka Zambo, Camille Kostmann, Alexandra Cousido-Siah, Bastien Morlet, Fabien Durbesson, Luc Negroni, Pascal Eberling, Pau Jané, Yves Nominé, Andras Zeke, Søren Østergaard, Élodie Monsellier, Renaud Vincentelli, Gilles Travé   +14 more
doaj   +1 more source

Letter to the Editor: An ultra-sensitive assay using cell-free DNA fragmentomics for multi-cancer early detection

, 2022
Xiuxiu Xu, Rui Liu, Yaqi Li, Ya Jiang, Wanxiangfu Tang, Junjie Peng, Jian Zhou, Shuang Chang, Qi Xue, Wei Guo, Long Zhang, Fangqi Liu, Sanjun Cai, Shaobo Mo, Xiaoji Ma, Naixin Liang, Xin Chen, Fengwei Tan, Yikuan Chen, Zheng Wang, Qianli Ma, Xian Zhang, Hua Bao, Shuyu Wu, Shugeng Gao, Shanshan Yang, Yulin Wei, Yang Shao, Hairong Bao, Xiangyu Zhang, Xinyu Wang, Xue Wu   +31 more
core   +1 more source

The New Language of Cell Free DNA: Fragmentomics, Methylomics, and CRISPR-Enabled Biosensing in Cancer Detection and Monitoring

Muharrem Okan Cakir, Mustafa Ozdogan
core   +1 more source

Cell-Free DNA Fragmentomics: The Novel Promising Biomarker

International Journal of Molecular Sciences, 2023
Cell-free DNA molecules are released into the plasma via apoptotic or necrotic events and active release mechanisms, which carry the genetic and epigenetic information of its origin tissues.
Qinyu Ge, Min Pan, Yunfei Bai
exaly   +2 more sources

Cell-Free DNA Fragmentomics: A Promising Biomarker for Diagnosis, Prognosis and Prediction of Response in Breast Cancer [PDF]

International Journal of Molecular Sciences, 2022
Identifying novel circulating biomarkers predictive of response and informative about the mechanisms of resistance, is the new challenge for breast cancer (BC) management.
Ugo De Giorgi, Samanta Sarti, Lorenzo Cecconetto   +2 more
exaly   +2 more sources