Mechanistic Modeling of cfDNA Fragmentome Dynamics Predicts Progression to Immunotherapy
BackgroundPlasma cell-free DNA (cfDNA) shows promise as predictive cancer biomarker, but mechanisms governing cfDNA production/fragmentation/elimination dynamics, and their relationships with tumor burden and disease progression, remain poorly understood.Methods We developed a mechanistic model jointly describing short (75-<580 bp) and long (≥580 ...
Nguyen Phuong, Linh +9 more
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