Results 11 to 20 of about 886 (145)

Quantitative fragmentomics allow affinity mapping of interactomes [PDF]

Nature Communications, 2022
Protein networks have been widely explored but most binding affinities remain unknown, limiting the quantitative interpretation of interactomes. Here the authors measure affinities of 65,000 interactions involving human PDZ domains and target sequence ...
Gergo Gogl, Boglarka Zambo, Camille Kostmann, Alexandra Cousido-Siah, Bastien Morlet, Fabien Durbesson, Luc Negroni, Pascal Eberling, Pau Jané, Yves Nominé, Andras Zeke, Søren Østergaard, Élodie Monsellier, Renaud Vincentelli, Gilles Travé   +14 more
doaj   +4 more sources

Liquid Biopsy in Early Screening of Cancers: Emerging Technologies and New Prospects [PDF]

Biomedicines
Liquid biopsy is moving beyond mutation-centric assays to multimodal frameworks that integrate cell-free DNA (cfDNA) signals with additional analytes such as circulating tumor cells (CTCs) and extracellular vesicles (EVs).
Hanyu Zhu, Zhenyu Li, Kunxin Xie, Sajjaad Hassan Kassim, Cheng Cao, Keyu Huang, Zipeng Lu, Chenshan Ma, Ying Li, Kuirong Jiang, Lingdi Yin   +10 more
doaj   +2 more sources

Fragmenting the future with FLARE: a comprehensive fragmentomics pipeline based on long-read nanopore sequencing [PDF]

Frontiers in Genetics
PurposeCell-free DNA (cfDNA) fragmentation patterns carry biological information beyond fragment length, revealing nuclease activity, chromatin organization, and tissue of origin.
Marica Ficorilli, Marta Lucchetta, Deborah Lenoci, Ilenia Rolli, Nicole Farina, Valentina Cristofaro, Lorenzo Giannini, Arianna Ottini, Alberto Deganello, Alberto Deganello, Stefano Cavalieri, Stefano Cavalieri, Lisa Licitra, Lisa Licitra, Loris De Cecco   +14 more
doaj   +2 more sources

Cell-free nucleic acid fragmentomics: A non-invasive window into cellular epigenomes

Translational Oncology
Clinical genomic profiling of cell-free nucleic acids (e.g. cell-free DNA or cfDNA) from blood and other body fluids has ushered in a new era in non-invasive diagnostics and treatment monitoring strategies for health conditions and diseases such as ...
Subhajyoti De
exaly   +3 more sources

Cancer-Like Fragmentomic Characteristics of Somatic Variants in Cell-Free DNA. [PDF]

Adv Sci (Weinh)
We report that in non‐cancerous subjects, cell‐free (cfDNA) molecules harboring somatic variants exhibit cancer‐like fragmentomic characteristics associated with clonal hematopoiesis. Importantly, these somatic variant‐associated fragmentomic aberrations are more pronounced in cancer patients. Leveraging such somatic variant‐associated signals in cfDNA,
Zhang Z, An Y, Yang M, Pan Y, Liu X, Gong F, Lin H, Tang B, Bai Y, Zhao X, Zhao Y, Du C, Sun K.   +12 more
europepmc   +4 more sources

Multidimensional cell-free DNA fragmentomics enables early detection of breast cancer [PDF]

Breast Cancer Research
Background Cell-free DNA (cfDNA) fragmentomics represents a transformative approach for early breast cancer detection, offering significant potential to improve patient survival through timely intervention.
Lixian Yang, Mengyang An, Heng song, Xuan Zhang, Meiqi Wang, Liu Yang, Xinle Wang, Hua Yang, Xinyue Hong, Zhenchuan Song   +9 more
doaj   +2 more sources

Comprehensive fragmentation of cell-free repetitive DNA for enhanced cancer detection in plasma [PDF]

Frontiers in Cell and Developmental Biology
BackgroundRepetitive elements account for a large proportion of the human genome and undergo alterations during early tumorigenesis. However, the exclusive fragmentation pattern of DNA-derived cell-free repetitive elements (cfREs) remains unclear ...
Mingguang Zhang, Shuohui Dong, Wei Rao, Shiwen Mei, Gang Hu, Ling Liu, Zhen Wang, Jianqiang Tang   +7 more
doaj   +2 more sources

Fragmentomic liquid biopsy enables early breast cancer detection, molecular subtyping and lymph node assessment [PDF]

Nature Communications
Breast cancer remains a leading global health concern in women, while screening is still limited by imaging accessibility and reduced sensitivity in dense breasts.
Yuxuan Zhu, Siwei Zheng, Yinkuan Shao, Jun Zhou, Xidong Gu, Lesang Shen, Xue Li, Wenjia Liu, Wei Xue, Haiqi Lu, Jun Zhou, Jinghua Ding, Haiming Deng, Jiayin Chen, Zhuohang Yu, Yao Yao, Wenjie Xia, Wuzhen Chen, Shanshan Sun, Zheng Wang, Tianyi Qian, Xiuyan Yu, Jian Liu, Yiding Chen, Ziao Lin, Jian Huang, Chao Ni   +26 more
doaj   +2 more sources

Cell-free DNA fragmentomics for preeclampsia risk assessment

Nature Communications
Preeclampsia (PE) is a pregnancy-specific hypertensive disorder that could lead to serious maternal and fetal complications, yet early identification of women at risk remains challenging because reliable biomarkers are limited.
Wenqiu Xu, Songchang Chen, Jia Li, Si Zhou, Yanning Yin, Zhixu Qiu, Jianguo Zhang, Cong Liu, Qiang Zhao, Gefei Xiao, Yan Zhou, Zhiguang Zhao, Xiao Zhang, Wenzhi Yang, Yunfang Wang, Huiqin Li, Zhen Yang, Suihua Feng, Qun Zhang, Weiping Chen, Huahua Li, Xiaohong Ruan, Hua Li, Sufen Zhang, Liqing Hu, Jie Qin, Wuyan Huang, Zhongzhe Li, Xianling Cao, Xuanyou Zhou, Naixin Xu, Dongxia Hou, Hong Dong, Jie Wang, Yaxian Liu, Quanfu Zhang, Xiaohua Wang, Lijian Zhao, Hefeng Huang, Chenming Xu   +39 more
doaj   +2 more sources

GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing [PDF]

Molecular Cancer
Background Gastrointestinal (GI) cancers are among the most prevalent and lethal malignancies worldwide. Early, non-invasive detection is essential for timely intervention and improved survival.
Ao Huang, De-Zhen Guo, Zhi-Xi Su, Yun-Shi Zhong, Liang Liu, Zhi-Guo Xiong, Dong-Li He, Bin Yan, Quan-Lin Li, Zhen Feng, Wen-Quan Wang, Pin-Xiang Lu, Meng-Jiang He, Zhi-Peng Qi, Qi Guo, Jian-Wen Cheng, Shi-Yu Zhang, Wei Guo, Qing Li, Guo-Yong Lin, Hui-Chuan Sun, Shuang-Jian Qiu, Qi-Ye He, Jia Fan, Ajay Goel, Rui Liu, Gang Jin, Xin-Rong Yang, Jian Zhou   +28 more
doaj   +2 more sources