Results 91 to 100 of about 1,183 (178)

Leveraging cfDNA fragmentomic features for the early detection of colorectal cancer

Frontiers in Immunology
Background Early detection of colorectal cancer (CRC) is crucial for improving patient outcomes. Cell-free DNA (cfDNA) analysis has emerged as a promising non-invasive approach for cancer detection. This study aims to develop a machine learning algorithm leveraging cfDNA fragmentomic features to accurately ...
Shan, Lina, Xu, Dengyong, Chen, Jie, Liu, Wenjia, Lin, Ji, Bao, Juhang, Huang, Jianfei, Zhang, Hanqing, Zhao, Hanchen, Xue, Wei, Lin, Ziao, Bai, Bingjun   +11 more
openaire   +2 more sources

Cell-Free DNA Fragmentomics beyond Early Detection: A Narrative Review of Treatment Monitoring Applications in Solid Tumors

Cell-free DNA (cfDNA) fragmentomics the analysis of non-random fragmentation patterns reflecting chromatin architecture and epigenetic regulation has emerged as a powerful approach for non-invasive cancer detection.
Aakash M, Venkateswaramurthy N, Premkumar G   +2 more
core   +1 more source

Fragmentomics in Pediatric Genetics: A New Frontier for Non-invasive Diagnosis of Rare Congenital and Metabolic Disorders

Cell-free DNA (cfDNA) circulating in plasma is fragmented non-randomly, and the resulting patterns carry information about the cells and tissues from which the molecules were released.
Elena Moschüring-Alieva, Stefan Bittmann, Elisabeth Luchter   +2 more
core   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Cancer treatment monitoring using cell-free DNA fragmentomes

Nature Communications
AbstractCirculating cell-free DNA (cfDNA) assays for monitoring individuals with cancer typically rely on prior identification of tumor-specific mutations. Here, we develop a tumor-independent and mutation-independent approach (DELFI-tumor fraction, DELFI-TF) using low-coverage whole genome sequencing to determine the cfDNA tumor fraction and validate ...
Iris van ’t Erve, Bahar Alipanahi, Keith Lumbard, Zachary L. Skidmore, Lorenzo Rinaldi, Laurel K. Millberg, Jacob Carey, Bryan Chesnick, Stephen Cristiano, Carter Portwood, Tony Wu, Erica Peters, Karen Bolhuis, Cornelis J. A. Punt, Jennifer Tom, Peter B. Bach, Nicholas C. Dracopoli, Gerrit A. Meijer, Robert B. Scharpf, Victor E. Velculescu, Remond J. A. Fijneman, Alessandro Leal   +21 more
openaire   +3 more sources

Abstract 3350: Cell-free DNA fragmentation patterns analyzed in over 15000 cancer patients reveal changes associated with tumor somatic mutations and result in improved sensitivity and specificity of somatic variant detection

, 2017
Background: Cell-free DNA (cfDNA) isolated from plasma consists of DNA fragments surviving clearance of dying cells and bloodstream trafficking. In cancer, these fragments carry the footprint of tumor somatic variation as well as its microenvironment ...
AmirAli Talasaz, Diana Abdueva, Helmy Eltoukhy, Darya Chudova   +3 more
core   +1 more source

Comprehensive fragmentation of cell-free repetitive DNA for enhanced cancer detection in plasma

Frontiers in Cell and Developmental Biology
BackgroundRepetitive elements account for a large proportion of the human genome and undergo alterations during early tumorigenesis. However, the exclusive fragmentation pattern of DNA-derived cell-free repetitive elements (cfREs) remains unclear ...
Mingguang Zhang, Shuohui Dong, Wei Rao, Shiwen Mei, Gang Hu, Ling Liu, Zhen Wang, Jianqiang Tang   +7 more
doaj   +1 more source

Abstract B041: 5-Base cfDNA Fragmentomics Reveals Cancer-Associated Alterations in Gallbladder Cancer

Background: Gallbladder cancer (GBC) is a highly aggressive malignancy that is typically diagnosed at advanced stages due to nonspecific symptoms and a lack of screening strategies.
Yu-Tang Gao, Jill Koshiol, Xiaolin Wu, Xiongfong Chen, Yongmei Zhao, Michael Daniels, Ann Hsing, Ling Su   +7 more
core   +1 more source

Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection

Nature Reviews Cancer
Genomic analyses of cell-free DNA (cfDNA) in plasma are enabling noninvasive blood-based biomarker approaches to cancer detection and disease monitoring. Current approaches for identification of circulating tumour DNA typically use targeted tumour-specific mutations or methylation analyses.
Daniel C. Bruhm, Nicholas A. Vulpescu, Zachariah H. Foda, Jillian Phallen, Robert B. Scharpf, Victor E. Velculescu   +5 more
openaire   +3 more sources

Gastric cancer detection by stomach chromatin–anchored salivary cell-free DNA fragmentomics

The current liquid biopsy paradigm rests mostly on plasma cell-free DNA (cfDNA), and only to a limited extent on other biofluids. Saliva is molecularly rich but difficult to use, as tumour signal must be separated from abundant background noise. Salivary
M. Constanza Camargo, Kyoung-Mee Kim, Jiyoung An, Irene Choi, David T. W. Wong, Matteo Pellegrini, Yingye Zheng, Fang Wei, Trinity Chan, Aaron Zander, Leila Syedmoradi, William Hsu, Akanksha Arora, David Elashoff, Karolina Kaczor-Urbanowicz, Ho Yeung Leung, Byung Hoon Min, Xiaojing Yang, Bradley Chan, Sung Kim, Sung Eun Oh, Wei Sun, Qianchuan He, Yong Kim, Jiaming Qiu, Jordan Cheng, Elliot Abemayor, Michael Weinstein, Neeti Swarup, Mohammad Arshad Aziz   +29 more
core   +1 more source