Results 11 to 20 of about 1,183 (178)

Circulating DNA fragmentomics and cancer screening

Cell Genomics, 2023
Summary: The high fragmentation of nuclear circulating DNA (cirDNA) relies on chromatin organization and protection or packaging within mononucleosomes, the smallest and the most stabilized structure in the bloodstream.
A.R. Thierry
exaly   +7 more sources

Cell-Free DNA Fragmentomics in Liquid Biopsy

Diagnostics, 2022
Cell-free DNA (cfDNA) in bodily fluids has rapidly transformed the development of noninvasive prenatal testing, cancer liquid biopsy, and transplantation monitoring. Plasma cfDNA consists of a mixture of molecules originating from various bodily tissues.
Spencer C Ding, Y M Dennis Lo
exaly   +6 more sources

Analysis of cfDNA fragmentomics metrics and commercial targeted sequencing panels [PDF]

Nature Communications
Fragmentomics based analysis of cell-free DNA (cfDNA) has recently emerged as a method to infer epigenetic and transcriptional data. Many of these reports analyze whole genome sequencing (WGS) which is not readily available clinically.
Kyle T. Helzer, Marina N. Sharifi, Jamie M. Sperger, Matthew R. Chrostek, Matthew L. Bootsma, Shannon R. Reese, Amy Taylor, Katie R. Kaufmann, Hannah Krause, Jennifer Schehr, Nan Sethakorn, David Kosoff, Christos E. Kyriakopoulos, Michael Bassetti, Grace Blitzer, John Floberg, Martin Sjöström, Andrew J. Armstrong, Himisha Beltran, Rana R. McKay, Felix Y. Feng, Ruth O’Regan, Kari B. Wisinski, Hamid Emamekhoo, Alex W. Wyatt, Joshua M. Lang, Shuang G. Zhao   +26 more
doaj   +6 more sources

Quantitative fragmentomics allow affinity mapping of interactomes [PDF]

Nature Communications, 2022
Protein networks have been widely explored but most binding affinities remain unknown, limiting the quantitative interpretation of interactomes. Here the authors measure affinities of 65,000 interactions involving human PDZ domains and target sequence ...
Gergo Gogl, Boglarka Zambo, Camille Kostmann, Alexandra Cousido-Siah, Bastien Morlet, Fabien Durbesson, Luc Negroni, Pascal Eberling, Pau Jané, Yves Nominé, Andras Zeke, Søren Østergaard, Élodie Monsellier, Renaud Vincentelli, Gilles Travé   +14 more
doaj   +5 more sources

Fragmentomic cfDNA Patterns in Noninvasive Prenatal Testing and Beyond [PDF]

Journal of Biomedicine and Translational Research, 2021
The release of fetoplacental cell-free DNA (cfDNA) into the maternal bloodstream opened up new avenues towards noninvasive prenatal testing (NIPT) for aneuploidies, hereditary DNA mutations and other pregnancy-related developmental disorders ...
Kavish Kohabir, Rob Wolthuis, Erik A. Sistermans   +2 more
doaj   +5 more sources

Cell-free DNA fragmentomics for preeclampsia risk assessment [PDF]

Nature Communications
Preeclampsia (PE) is a pregnancy-specific hypertensive disorder that could lead to serious maternal and fetal complications, yet early identification of women at risk remains challenging because reliable biomarkers are limited.
Wenqiu Xu, Songchang Chen, Jia Li, Si Zhou, Yanning Yin, Zhixu Qiu, Jianguo Zhang, Cong Liu, Qiang Zhao, Gefei Xiao, Yan Zhou, Zhiguang Zhao, Xiao Zhang, Wenzhi Yang, Yunfang Wang, Huiqin Li, Zhen Yang, Suihua Feng, Qun Zhang, Weiping Chen, Huahua Li, Xiaohong Ruan, Hua Li, Sufen Zhang, Liqing Hu, Jie Qin, Wuyan Huang, Zhongzhe Li, Xianling Cao, Xuanyou Zhou, Naixin Xu, Dongxia Hou, Hong Dong, Jie Wang, Yaxian Liu, Quanfu Zhang, Xiaohua Wang, Lijian Zhao, Hefeng Huang, Chenming Xu   +39 more
doaj   +3 more sources

Multidimensional roles of cfDNA fragmentomics in preeclampsia: from placental hypoxia and TLR9 inflammation to clinical risk stratification [PDF]

Frontiers in Medicine
Cell-free DNA (cfDNA) has emerged as a pivotal biomarker for predicting preeclampsia (PE), a multisystem syndrome characterized by placental hypoperfusion and systemic inflammation.
Ziyi Guo, Bin Zhang, Di Yang, Li Wang
exaly   +4 more sources

DECIPHER-PRAD: an advanced fragmentomics-based cell-free DNA assay for prostate cancer early detection [PDF]

Cell Communication and Signaling
Early detection of prostate cancer is limited by the poor specificity of prostate-specific antigen (PSA)-based screening. Cell-free DNA (cfDNA) fragmentomics offers a promising non-invasive approach to improve screening accuracy and risk stratification ...
Fufeng Wang
exaly   +3 more sources

Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models.

PLoS Genetics, 2022
Urinary cell-free DNA (ucfDNA) is a potential biomarker for bladder cancer detection. However, the biological characteristics of ucfDNA are not well understood.
Meihui Chen, Rebecca W Y Chan, Peter P H Cheung, Meng Ni, Danny K L Wong, Ze Zhou, Mary-Jane L Ma, Liangbo Huang, Xinzhou Xu, Wing-Shan Lee, Guangya Wang, Kathy O Lui, W K Jacky Lam, Jeremy Y C Teoh, Chi-Fai Ng, Peiyong Jiang, K C Allen Chan, Rossa W K Chiu, Y M Dennis Lo   +18 more
doaj   +4 more sources

Fragmentomics features of cell free DNA in eating disorders [PDF]

Translational Psychiatry
Eating disorders are lacking reliable biomarkers despite their severe psychiatric and medical burden. In this study, we examined plasma cell-free DNA (cfDNA) from patients with the restrictive (ANR), or binge–purge (ANBP) subtypes of anorexia nervosa, as
Alisa Burova, Camille Verebi, Nicolas Lebrun, Juliette Nectoux, Audrey Boutonnet, Philibert Duriez, Philip Gorwood, Nicolas Ramoz, Thierry Bienvenu   +8 more
doaj   +3 more sources