Results 21 to 30 of about 1,183 (178)

Circulating Cell-free DNA Fragmentomics Detection and Beyond [PDF]

Aging Dis
Circulating cell-free DNA (cfDNA) comprises DNA fragments released into bodily fluids via apoptosis, necrosis, or phagocytosis. cfDNA encapsulates both fragmentomics (structural) and non-fragmentomics (sequence/epigenetic) information from source cells, thereby representing a promising biomarker.
Liu T, Li Z, Chen S, Zhong J.
exaly   +4 more sources

Seminal plasma cfDNA fragmentomics landscape delineates male infertility subtypes [PDF]

Clinical Epigenetics
Background While cell-free DNA (cfDNA) fragmentomics has transformed liquid biopsy applications in prenatal screening and oncology, its potential in male reproductive health remains unexplored.
Xiaoyu Wu, Fan Meng, Huiping Zhang, Zeqing Li, Kai Zhao   +4 more
doaj   +4 more sources

Early detection of uterine corpus endometrial carcinoma utilizing plasma cfDNA fragmentomics

BMC Medicine
Background Uterine corpus endometrial carcinoma (UCEC) is a prevalent gynecologic malignancy with a favorable prognosis if detected early. However, there is a lack of accurate and reliable early detection tests for UCEC.
Jing Liu, Dan Hu, Yibin Lin, Xiaoxi Chen, Ruowei Yang, Li Li, Yanyan Zhan, Hua Bao, LeLe Zang, Mingxuan Zhu, Fei Zhu, Junrong Yan, Dongqin Zhu, Huiqi Zhang, Benhua Xu, Qin Xu   +15 more
doaj   +2 more sources

From detection to action: ctDNA-MRD surveillance and translational strategies in early breast cancer [PDF]

Frontiers in Oncology
Recurrence remains a major cause of mortality in early breast cancer (EBC), and conventional follow-up often identifies relapse only after clinically detectable disease has emerged. Circulating tumor DNA–based minimal residual disease (ctDNA-MRD) testing
Jing Feng, Yujun Tong, Zhen Zhang, Ye Zhang   +3 more
doaj   +2 more sources

Epigenomic modifications define chromatin states to regulate cell-free DNA fragmentomics [PDF]

Nature Communications
Plasma cell-free DNA (cfDNA) fragmentomics offer promising cancer biomarkers, but their molecular regulation remains elusive. Here, we investigate the role of epigenomic modifications in cfDNA fragmentation.
Fanglei Gong, Yuqi Pan, Huizhen Lin, Yunyun An, Mengqi Yang, Xiaoyi Liu, Yunxia Bai, Zhenyu Zhang, Bianbian Tang, Kun Zhang, Xin Zhao, Yu Zhao, Changzheng Du, Xuetong Shen, Kun Sun   +14 more
doaj   +2 more sources

The emerging clinical relevance of cell-free DNA in lupus: from mechanistic insights to therapeutic opportunities [PDF]

Frontiers in Immunology
Systemic lupus erythematosus (SLE) is a complex autoimmune disease often characterised by dysregulated immune responses to self-DNA. Emerging evidence highlights the role of cell-free DNA (cfDNA) in promoting immune activation in SLE.
Emily Jones, Kiki Cano-Gamez
doaj   +2 more sources

A cfDNA fragmentomics classifier for noninvasive differentiation of benign and malignant renal masses [PDF]

Molecular Biomedicine
Noninvasive differentiation of malignant and benign renal masses remains a major clinical challenge, particularly for radiologically indeterminate lesions.
Linfei Li, Cong Wang, Song Wang, Jun Zheng, Jian Fu, Ling Wei, Juan Shen, Yuwei Li, Xinyue Hong, Chunman Wu, Wei Chen, Wei Gong, Yongquan Wang   +12 more
doaj   +2 more sources

Cell-free nucleic acid fragmentomics: A non-invasive window into cellular epigenomes

Translational Oncology
Clinical genomic profiling of cell-free nucleic acids (e.g. cell-free DNA or cfDNA) from blood and other body fluids has ushered in a new era in non-invasive diagnostics and treatment monitoring strategies for health conditions and diseases such as ...
Subhajyoti De
exaly   +3 more sources

Fragmenting the future with FLARE: a comprehensive fragmentomics pipeline based on long-read nanopore sequencing [PDF]

Frontiers in Genetics
PurposeCell-free DNA (cfDNA) fragmentation patterns carry biological information beyond fragment length, revealing nuclease activity, chromatin organization, and tissue of origin.
Marica Ficorilli, Marta Lucchetta, Deborah Lenoci, Ilenia Rolli, Nicole Farina, Valentina Cristofaro, Lorenzo Giannini, Arianna Ottini, Alberto Deganello, Alberto Deganello, Stefano Cavalieri, Stefano Cavalieri, Lisa Licitra, Lisa Licitra, Loris De Cecco   +14 more
doaj   +2 more sources

Cell‐free epigenomes enhanced fragmentomics‐based model for early detection of lung cancer

Clinical and Translational Medicine
Background Lung cancer is a leading cause of cancer mortality, highlighting the need for innovative non‐invasive early detection methods. Although cell‐free DNA (cfDNA) analysis shows promise, its sensitivity in early‐stage lung cancer patients remains a
Yadong Wang, Qiang Guo, Zhicheng Huang, Liyang Song, Fei Zhao, Tiantian Gu, Zhe Feng, Haibo Wang, Bowen Li, Daoyun Wang, Bin Zhou, Chao Guo, Yuan Xu, Yang Song, Zhibo Zheng, Zhongxing Bing, Haochen Li, Xiaoqing Yu, Ka Luk Fung, Heqing Xu, Jianhong Shi, Meng Chen, Shuai Hong, Haoxuan Jin, Shiyuan Tong, Sibo Zhu, Chen Zhu, Jinlei Song, Jing Liu, Shanqing Li, Hefei Li, Xueguang Sun, Naixin Liang   +32 more
doaj   +2 more sources