Regulation of Francisella tularensis Virulence [PDF]
Frontiers in Cellular and Infection Microbiology, 2011 Francisella tularensis is one of the most virulent bacteria known and a Centers for Disease Control and Prevention Category A select agent. It is able to infect a variety of animals and insects and can persist in the environment, thus Francisella spp ...
Shipan eDai +7 more
doaj +3 more sources
De Novo Design of High-Affinity Miniprotein Binders Targeting Francisella Tularensis Virulence Factor. [PDF]
Angew Chem Int Ed EnglHybrid physics and deep‐learning enabled design methods identified miniprotein binders to Flpp3 (Francisella‐like lipoprotein), a key virulence factor from Francisella tularensis. Multiple candidates with nanomolar to picomolar binding affinities were obtained using yeast surface display screening and further experimental optimization.
Gokce-Alpkilic G +18 more
europepmc +3 more sources
Francisella tularensisin Rodents, China [PDF]
Emerging Infectious Diseases, 2006 A total of 420 rodents in China were examined for Francisella tularensis by polymerase chain reaction. The infection rates were 4.76% in total, and 11.65%, 10.00%, 6.56%, 1.77%, and 0% in Jilin, Xinjiang, Heilongjiang, Inner Mongolia, and Zhejiang, respectively. Sequence analysis showed that all the detected agents belonged to F.
Fang Zhang +10 more
openalex +4 more sources
Early infection-induced natural antibody response
Scientific Reports, 2021 There remains to this day a great gap in understanding as to the role of B cells and their products—antibodies and cytokines—in mediating the protective response to Francisella tularensis, a Gram-negative coccobacillus belonging to the group of ...
Klara Kubelkova +4 more
doaj +1 more source
Molecular epidemiology of tick-borne pathogens along Hexi Corridor of Gansu Province
Di-san junyi daxue xuebao, 2021 Objective To investigate the possible tick-borne pathogens along the Hexi Corridor of Gansu Province. Methods Ticks were collected from animal surfaces, residents' livestock barns and by dragging a cloth over vegetation, and brought back alive to our ...
ZHANG Fang, WANG Xiaoheng
doaj +1 more source
Francisella tularensis subsp. tularensis induces a unique pulmonary inflammatory response: role of bacterial gene expression in temporal regulation of host defense responses. [PDF]
PLoS ONE, 2013 Pulmonary exposure to Francisella tularensis is associated with severe lung pathology and a high mortality rate. The lack of induction of classical inflammatory mediators, including IL1-β and TNF-α, during early infection has led to the suggestion that F.
Kathie-Anne Walters +8 more
doaj +1 more source
Inguinal Ulceroglandular Tularemia Caused by Francisella tularensis Subspecies holarctica, Canada
Emerging Infectious Diseases, 2021 Tularemia is a zoonotic disease caused by the gram-negative coccobacillus Francisella tularensis, a Biosafety Level 3 pathogen and potential agent of bioterrorism.
Carl Boodman +6 more
doaj +1 more source
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. [PDF]
, 2010 Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18. We elucidate here how host macrophages recognize F.
Alnemri, Emad S +12 more
core +3 more sources
Comparative Transcriptional Analyses of Francisella tularensis and Francisella novicida. [PDF]
PLoS ONE, 2016 Francisella tularensis is composed of a number of subspecies with varied geographic distribution, host ranges, and virulence. In view of these marked differences, comparative functional genomics may elucidate some of the molecular mechanism(s) behind ...
Siva T Sarva +3 more
doaj +1 more source
Characterization of Francisella species isolated from the cooling water of an air conditioning system. [PDF]
, 2015 Strains of Francisella spp. were isolated from cooling water from an air conditioning system in Guangzhou, China. These strains are Gram negative, coccobacilli, non-motile, oxidase negative, catalase negative, esterase and lipid esterase positive.
Atwill, Edward +6 more
core +3 more sources