Chilean Honey as Alternative Antibacterial: In Vitro Activity Against Multidrug-Resistant Canine Bacterial Pathogens. [PDF]
Animals (Basel)Mireles-Villanueva MV +7 more
europepmc +1 more source
Emerging strategies to target metastasis and therapy resistance in melanoma
Molecular Oncology, Volume 20, Issue 5, Page 1111-1114, May 2026.Emerging studies propose new approaches to interfere with melanoma progression. In recognition of melanoma awareness month, at Molecular Oncology, we highlight recently published research articles, focusing on novel therapeutic targets driving metastatic spread and outlining different strategies to overcome resistance to BRAF inhibitors and anti‐PD‐1 ...
Amel Aziba
wiley +1 more source
Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization
Advanced Science, Volume 13, Issue 26, 8 May 2026.This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin +11 more
wiley +1 more source
Advanced Science, Volume 13, Issue 26, 8 May 2026.Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li +11 more
wiley +1 more source
Analysis of Protein and Lipid Dynamics Using Confocal Fluorescence Recovery After Photobleaching. [PDF]
Curr ProtocDay CA, Kraft LJ, Kang M, Kenworthy AK.
europepmc +1 more source
Coacervate‐Mediated Lysosome‐Targeting Antibody Delivery for Protein Degradation
Advanced Science, Volume 13, Issue 25, 4 May 2026.Targeting coacervates to the lysosome in the cytoplasm is a challenge. Here, we convert a tetrapeptide into lysosome‐targeting, membrane‐translocating coacervates. The lysosome‐sorting peptide coacervates facilitate coacervate‐mediated delivery of antibody antigen complexes and a PROTAC compound to the lysosome for the targeted degradation of cancer ...
Dingdong Yuan +7 more
wiley +1 more source
Multifaceted bioactivity of brown seaweed-derived fucoidan from the Indian Coastline: A natural health product candidate. [PDF]
PLoS OnePrajapati M +5 more
europepmc +1 more source
Nucleation Kinetics Reveals a Distinct Biological Function Space of Biomolecular Condensates
Advanced Science, Volume 13, Issue 26, 8 May 2026.This study utilizes microfluidics to quantify the nucleation rates of dense liquid phases within dilute solutions and of the reverse process, in which dilute voids nucleate inside condensates. The interfacial tension is identified as the key determinant of both processes.
Leif‐Thore Deck +5 more
wiley +1 more source
Biochemical Reconstitution and FRAP Analysis of Membrane-Associated Condensates on Supported Lipid Bilayers. [PDF]
Bio ProtocZeng L, Su X.
europepmc +1 more source
A liquid-like organelle at the root of motile ciliopathy [PDF]
, 2018 Boulgakov, Alexander A +7 more
core +1 more source