Results 121 to 130 of about 167,750,294 (239)
Advanced Science, EarlyView.We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang +19 more
wiley +1 more source
, 1929 Black and white photograph of workers digging for fossils at the dinosaur quarry near Jensen, Utah, in 1924. Dr. Fred Pack is standing and watching.
Pack, Frederick J. (Frederick James), 1875-1938
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Advanced Science, EarlyView.The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English +9 more
wiley +1 more source
Hansel Valley Earthquake, 1934 - Mrs. Pack
, 1934 Black and white photograph by Fred Pack during a visit to Hansel Valley in Box Elder County, Utah, following an earthquake on March 12, 1934.
Pack, Frederick J. (Frederick James), 1875-1938
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Advanced Science, EarlyView.Time‐resolved synchrotron radiography reveals the internal evolution of electrochemical double‐layer capacitors under abusive overcharge. EDLCs are shown to follow a thermally driven failure pathway involving electrolyte decomposition, gas generation, and structural collapse, distinct from chemically driven thermal runaway effects of Lithium‐ion ...
Thomas Dore +19 more
wiley +1 more source
Grace, Idaho, 1923: Pipe lines built by QR Pack
, 1923 Black and white photograph by Fred Pack during a visit to his brother, Quince R. Pack, at Grace, Idaho, in July of 1923.
Pack, Frederick J. (Frederick James), 1875-1938
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The Interplay of Curvature, Geometry, and Topology Shapes Tissue Organisation in Epithelial Shells
Advanced Science, EarlyView.Purely geometric 3D Voronoi models predict the organisation of epithelial shells. The interplay of curvature, geometry, and topology enriches the number of pentagons in shells with lower number of cells. Small MDCK cysts and Mouse embryos match the top polygonal configurations in a compactness‐based ranking derived from the Voronoi model. In conclusion,
Laura Morato +9 more
wiley +1 more source
Hansel Valley Earthquake, 1934 - Eleanor Pack
, 1934 Black and white photograph by Fred Pack during a visit to Hansel Valley in Box Elder County, Utah, following an earthquake on March 12, 1934.
Pack, Frederick J. (Frederick James), 1875-1938
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Advanced Science, EarlyView.MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia +4 more
wiley +1 more source
Revisiting front-of-pack nutrition labeling policies in Indonesia
Effective implementation of Government Regulation (GR) No. 28/2024 on addressing excessive sugar, salt, and fats (SSF) consumption requires robust front-of-pack nutrition labeling (FoPNL) technical guidelines that prioritize public health while ...
Nidhal, Muhammad, Budiman, Ibnu
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