Fucosylated Chondroitin Sulfates from the Body Wall of the Sea Cucumber Holothuria forskali [PDF]
Journal of Biological Chemistry, 2014 Fucosylated chondroitin sulfate (fCS) extracted from the sea cucumber Holothuria forskali is composed of the following repeating trisaccharide unit: -> 3)GalNAc beta 4,6S(1 -> 4) [Fuc alpha X(1 -> 3)]GlcA beta(1 ->, where X stands for different sulfation patterns of fucose (X = 3,4S (46%), 2,4S (39%), and 4S (15%)).
Panagos, Charalampos G. +14 more
openaire +1 more source
Materials of marine origin: a review on polymers and ceramics of biomedical interest [PDF]
, 2012 Marine organisms are constituted by materials with a vast range of properties and characteristics that may justify their potential application within the biomedical field.
Alves, A. +9 more
core +1 more source
Antioxidant Potential of Sea Cucumbers and Their Beneficial Effects on Human Health
Marine Drugs, 2022 Sea cucumbers are considered a luxury food item and used locally in traditional medication due to their impressive nutritional profile and curative effects.
Abul Hossain +2 more
doaj +1 more source
Marine Drugs, 2015 Anionic polysaccharides fucosylated chondroitin sulfates (FCS) from holothurian species were shown to affect various biological processes, such as metastasis, angiogenesis, clot formation, thrombosis, inflammation, and some others.
Alexey G. Gerbst +3 more
doaj +1 more source
Biomedicines, 2023 Human epidermal growth factor receptor 2 (HER2) is overexpressed in numerous cancer cell types. Therapeutic antibodies and chimeric antigen receptors (CARs) against HER2 were developed to treat human tumors.
Irina O. Chikileva +15 more
doaj +1 more source
Inhibition of SARS-CoV-2 wild-type (Wuhan-Hu-1) and Delta (B.1.617.2) strains by marine sulfated glycans [PDF]
, 2022 The Coronavirus disease pandemic has steered the global therapeutic research efforts toward the discovery of potential anti-severe acute respiratory syndrome coronavirus (SARS-CoV-2) molecules.
Dwivedi, Rohini +3 more
core +2 more sources
Marine Drugs, 2019 Fucosylated chondroitin sulfate (fCS) is a glycosaminoglycan found up to now exclusively in the body wall of sea cucumbers. It shows several interesting activities, with the anticoagulant and antithrombotic as the most attractive ones.
Giulia Vessella +6 more
doaj +1 more source
Langerin-Heparin Interaction: Two Binding Sites for Small and Large Ligands as revealed by a combination of NMR Spectroscopy and Cross-Linking Mapping Experiments [PDF]
, 2015 Langerin is a C-type lectin present on Langerhans cells that mediates capture of pathogens in a carbohydrate-dependent manner, leading to subsequent internalization and elimination in the cellular organelles called Birbeck granules.
Angulo, Jesus +9 more
core +7 more sources
A new heparan sulfate from the mollusk nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of plasmodium falciparum [PDF]
, 2020 Despite treatment with effective antimalarial drugs, the mortality rate is still high in severe cases of the disease, highlighting the need to find adjunct therapies that can inhibit the adhesion of Pf-iEs.
Albrecht, L. +10 more
core +1 more source
The protective role of fucosylated chondroitin sulfate, a distinct glycosaminoglycan, in a murine model of streptozotocin-induced diabetic nephropathy. [PDF]
PLoS ONE, 2014 Heparanase-1 activation, albuminuria, and a decrease in glomerular heparan sulfate (HS) have been described in diabetic nephropathy (DN). Glycosaminoglycan (GAG)-based drugs have been shown to have renoprotective effects in this setting, although recent ...
Conrado L R Gomes +10 more
doaj +1 more source