Results 101 to 110 of about 17,469 (199)

Stable overexpression of native and artificial miRNAs for the production of differentially fucosylated antibodies in CHO cells

Engineering in Life Sciences
Cell engineering strategies typically rely on energy‐consuming overexpression of genes or radical gene‐knock out. Both strategies are not particularly convenient for the generation of slightly modulated phenotypes, as needed in biosimilar development of ...
Patrick Schlossbauer, Lukas Naumann, Florian Klingler, Madina Burkhart, René Handrick, Kathrin Korff, Christian Neusüß, Kerstin Otte, Friedemann Hesse   +8 more
doaj   +1 more source

Biomolecular Fingerprint of Crohn's Disease: A Comparative Raman Spectroscopic Study of Blood and Tissue Samples

Journal of Biophotonics, Volume 19, Issue 1, January 2026.
Raman spectroscopy is evaluated as a minimally invasive tool for diagnosing and monitoring Crohn's disease. Correlation between plasma and tissue spectra indicates that plasma measurements reflect local intestinal inflammation, while therapy‐associated biochemical shifts toward healthy profiles highlight its potential for disease monitoring and ...
M. Daniyal Ghauri, Maria Victoria Fernandez, Giovanni Santacroce, Sumedha Chanda, Irene Zammarchi, Ivan Capobianco, Sanathana Konugolu Venkata Sekar, Subrata Ghosh, Katarzyna Komolibus, Stefan Andersson‐Engels, Marietta Iacucci, Rekha Gautam   +11 more
wiley   +1 more source

Soluble selectins and highly fucosylated ?1-antichymotrypsin in rheumatoid arthritis patients

Journal of Medical Science, 2015
Introduction. Fucosylation of acute phase proteins and serum soluble selectin levels is increased in rheumatoid arthritis (RA) patients and can influence leukocyte extravasation. Aim.
Anna Olewicz-Gawlik, Izabela Korczowska-Łącka, Paweł Hrycaj   +2 more
doaj   +1 more source

CDG due to Defective Membrane Transporters: Update

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Congenital disorders of glycosylation are genetic defects in the glycoprotein and glycolipid glycan assembly and attachment. Some 200 CDG have been reported since the first clinical description in 1980. Most CDG are enzymatic deficiencies, but 13 (6.5%) are defects in the ER, Golgi apparatus (GA), and plasma membrane transporters.
D. Quelhas, C. R. Ferreira, J. Jaeken
wiley   +1 more source

MET Enhances Amivantamab Binding to EGFR and Antibody‐Dependent Cellular Toxicity

Cancer Science, Volume 117, Issue 1, Page 118-129, January 2026.
Amivantamab binds to EGFR domain 3 and the MET Sema domain, and the EGFR‐MET‐amivantamab trimer was successfully visualized using high‐speed atomic force microscopy (HS‐AFM). MET enhances the binding of amivantamab to EGFR and increases antibody‐dependent cellular cytotoxicity (ADCC) even at low concentrations of amivantamab.
Shigeki Sato, Neval Yilmaz, Sachiko Arai, Katsuya Sakai, Hiroki Sato, Yuya Murase, Tsukasa Ueda, Hayato Koba, Shigeki Nanjo, Yuichi Tambo, Hiroshi Kotani, Koji Fukuda, Hiroaki Taniguchi, Romain Amyot, Holger Flechsig, Hideko Isozaki, Kunio Matsumoto, Seiji Yano   +17 more
wiley   +1 more source

Robinia pseudoacacia L. Flower Exosome‐Like Nanoparticles (RFELNs) Activate AhR/IL‐22 to Relieve Intestinal Barrier Dysfunction Through Regulating Gut Microbiota‐Interrelated Tryptophan Metabolism in Ulcerative Colitis Mice

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Background Intestinal barrier dysfunction is a key driver of ulcerative colitis (UC) recurrence and chronic persistence. Modulating group 3 innate lymphoid cells (ILC3) activity and tryptophan‐derived metabolites is crucial for enhancing mucosal repair in UC. Robinia pseudoacacia L. flower exosome‐like nanoparticles (RFELNs) could ameliorate intestinal
Feihan Shen, Kewen Sun, Jianguo Song, Xueping Chen, Juan Dai, Ying Qi, Liwen Zhang, Liang Ma, Elena Niccolai   +8 more
wiley   +1 more source

A plant cell‐based platform for the expression of complex proteins with fucose‐reduced sialylated N‐glycans

Plant Biotechnology Journal, EarlyView.
Saeideh Dianatkhah, Benjamin Kogelmann, Stanislav Melnik, Florian Eminger, Somanath Kallolimath, Lin Sun, Delia Sumesgutner, Michael W. Traxlmayr, Markus Sack, Eva Stoger, Herta Steinkellner   +10 more
wiley   +1 more source

N-Glycomic and Transcriptomic Changes Associated with CDX1 mRNA Expression in Colorectal Cancer Cell Lines

Cells, 2019
The caudal-related homeobox protein 1 (CDX1) is a transcription factor, which is important in the development, differentiation, and homeostasis of the gut.
Stephanie Holst, Jennifer L. Wilding, Kamila Koprowska, Yoann Rombouts, Manfred Wuhrer   +4 more
doaj   +1 more source

Insights into fucose metabolism: SLC35C1-independent fucosylation discriminates against mannose-derived GDP-fucose [PDF]

, 2021
Edyta Skurska, B Szulc, Dorota Maszczak‐Seneczko, Maciej Wiktor, Wojciech Wiertelak, Mariusz Olczak   +5 more
openalex   +1 more source

Novel insight into FCSK‐congenital disorder of glycosylation through a CRISPR‐generated cell model

Molecular Genetics & Genomic Medicine
Background FCSK‐congenital disorder of glycosylation (FCSK‐CDG) is a recently discovered rare autosomal recessive genetic disorder with defective fucosylation due to mutations in the fucokinase encoding gene, FCSK.
Maryam Fazelzadeh Haghighi, Hossein Jafari Khamirani, Jafar Fallahi, Ali Arabi Monfared, Korosh Ashrafi Dehkordi, Seyed Mohammad Bagher Tabei   +5 more
doaj   +1 more source