Results 121 to 130 of about 3,632,451 (277)

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Neural Representations of Neuropsychiatric Symptoms in Alzheimer's Disease Continuum Using Pathology‐Based Functional Connectivity Analysis

Brain and Behavior
Objectives: Neuropsychiatric symptoms (NPS) in the Alzheimer's disease continuum affect the quality of life for patients and caregivers. Therefore, elucidating the mechanisms of NPS is needed to better understand NPS and enhance patient care.
Taein Lee, Yong Jeong, for the Alzheimer's Disease Neuroimaging Initiative#   +2 more
doaj   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Differential Effects of Lipid Bilayers on αPSM Peptide Functional Amyloid Formation. [PDF]

Int J Mol Sci, 2023
Kristoffersen K, Hansen KH, Andreasen M.
europepmc   +1 more source

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

Advanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren, Qian Yue, Ning Gao, Qiu‐Lian Hao, Yan Huo, Chuchu Li, Xinyue Leng, Lu‐Lu Sun, Maggie Pui Man Hoi, Hai‐Hao Han, Mingliang Ma, Xu‐Wen Li   +11 more
wiley   +1 more source

Pathological and Functional Amyloid Fibrils-Part I. [PDF]

Int J Mol Sci, 2022
Kuznetsova IM, Turoverov KK.
europepmc   +1 more source

Duodenum amyloid deposition

, 2005
Duodenum with amyloid deposition in lamina propria. Amyloid etiology unknown.

core  

Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis

, 2015
Item does not contain fulltextIMPORTANCE: Cerebral amyloid-beta aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are
Fagan, A.M., Madsen, K., Prabhakar, S., Alcolea, D., Ramakers, I.H., Nordberg, A., Spiru, L., Waldemar, G., Alexander, M., Scheltens, P., Drzezga, A., Zboch, M., Leon, M., Freund-Levi, Y., Herukka, S.K., Hellwig, S., Kohler, S., Sarazin, M., Chetelat, G., Rodriguez-Rodriguez, E., Aalten, P., Ivanoiu, A., Johannsen, P., Teunissen, C.E., Forster, S., Novak, G.P., Blennow, K., Sanchez-Juan, P., Verhey, F.R.J., van Buchem, M.A., Gkatzima, O., Klunk, W.E., Meulenbroek, O., Mroczko, B., Verhey, F.R., Almdahl, I.S., Bibeau, K., Fladby, T., Møllergård, H.M., Struyfs, H., Vos, S.J., Schütte, C., Camus, V., Lleo, A., Frederiksen, K.S., van der Flier, W.M., Baldeiras, I., Hildebrandt, H., Chen, K., Froelich, L., Koglin, N., Lisetti, V., Gordon, M.F., Rowe, C.C., Foskett, N., Meulenbroek, O.V., Kornhuber, J., Mollergard, H.M., Cavedo, E., Gill, K.D., Rodrigue, K.M., Scheltens, P.J., Aarsland, D., Newberg, A., Wolk, D.A., Hampel, H., Roe, C.M., Vandenberghe, R., Parnetti, L., Peters, O., Verbeek, M.M., Tijms, B.M., Ishihara, L., Kramberger, M.G., Mintun, M.A., Rot, U., Zetterberg, H., Villemagne, V.L., Mattsson, N., Morris, J.C., Soininen, H., Mussele, S. Van der, Laere, K. Van, Brooks, D.J., Ossenkoppele, R., de Mendonça, A., Wallin, Å.K., Grimmer, T., Van Laere, K., Landau, S.M., Sabri, O., Na, D.L., Oliveira, C.R., Rinne, J.O., Soetewey, F., Gomez-Tortosa, E., Rüther, E., van Waalwijk van Doorn, L.J., Fleisher, A.S., Kapaki, E., Buchem, M.A. van, Meyer, P.T., Hausner, L., Schröder, J., Berckel, B.N. van, Rabinovici, G.D., Frisoni, G.B., Ford, L., van Berckel, B.N., Rami, L., Gabryelewicz, T., Mendonca, A. de, et al., Fortea, J., Flier, W.M. van der, Wallin, A., Jansen, W.J., Visser, P.J., Knol, D.L., Maier, W., Cohen, A.D., Lee, D.Y., Wiltfang, J., Paraskevas, G.P., Mok, V., Arnold, S.E., Marcusson, J., Tsolaki, M., Barthel, H., Santana, I., Klimkowicz-Mrowiec, A., Molinuevo, J.L., Engelborghs, S., Resende de Oliveira, C., Nordlund, A., Perera, G., de Leon, M., Kandimalla, R., Popp, J., Jagust, W.J., Seo, S.W., Van der Mussele, S.   +141 more
core   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Structural insights into Escherichia coli CsgA amyloid fibril assembly revisited

mBio
Curli are a widespread component of proteobacterial biofilms. They are functional amyloid fibers that aid in structuring the extracellular matrix that surrounds these multicellular communities. As a functional amyloid, they are the product of a dedicated
Mike Sleutel, Han Remaut
doaj   +1 more source