Results 131 to 140 of about 3,632,451 (277)

HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation. [PDF]

Cell Res, 2023
Wu E, He W, Wu C, Chen Z, Zhou S, Wu X, Hu Z, Jia K, Pan J, Wang L, Qin J, Liu D, Lu J, Wang H, Li J, Wang S, Sun L.   +16 more
europepmc   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3. [PDF]

Nat Commun, 2023
Garcia-Pardo J, Bartolomé-Nafría A, Chaves-Sanjuan A, Gil-Garcia M, Visentin C, Bolognesi M, Ricagno S, Ventura S.   +7 more
europepmc   +1 more source

Polymer Concepts in Cellular Function

Advanced Science, EarlyView.
Miao Yu, Shikha Dhiman, Dorothee Dormann, Frauke Gräter, Katja Luck, Friederike Schmid, Andreas Walther, Edward A. Lemke   +7 more
wiley   +1 more source

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

Polyphenol Effect on the Interactions Between Functional Proteins and Amyloid Fibrils

East European Journal of Physics
Among a wide variety of protein-protein interactions, the complexation of functionally important proteins with pathogenic protein aggregates (amyloid fibrils) attracts particular interest in view of its possible contribution to amyloid cytotoxicity.
U. Malovytsia, V. Trusova, M. Thomsen, K. Vus, O. Zhytniakivska, G. Gorbenko   +5 more
doaj   +1 more source

Interaction of membrane vesicles with the Pseudomonas functional amyloid protein FapC facilitates amyloid formation. [PDF]

BBA Adv, 2022
Najarzadeh Z, Mohammad-Beigi H, Pedersen JN, Christiansen G, Pedersen JS, Nielsen J, Otzen DE.   +6 more
europepmc   +1 more source

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

Direct toll-like receptor 4 inhibition in Alzheimer’s disease models: a focused scoping review of inflammatory, amyloid-handling, and functional outcomes

Frontiers in Aging Neuroscience
ObjectiveThis focused scoping review evaluated whether direct toll-like receptor 4 (TLR4) inhibition, antagonism, or genetic suppression in Alzheimer’s disease (AD)-related models was associated with concordant inflammatory, amyloid-β (Aβ)-handling, and ...
Xiaolu Ren, Xiaolu Ren, Xinyu Jin, Ling Li, Fang Li   +4 more
doaj   +1 more source

Droplet and fibril formation of the functional amyloid Orb2. [PDF]

J Biol Chem, 2021
Ashami K, Falk AS, Hurd C, Garg S, Cervantes SA, Rawat A, Siemer AB.   +6 more
europepmc   +1 more source