Functional amyloid - Open Access .click

Results 141 to 150 of about 3,632,451 (277)

Temporal‐Targeted Accelerated 40 Hz tACS Enhances Cognitive Function and Network Integration in Alzheimer's Disease: A Randomized Clinical Trial

Advanced Science, EarlyView.
Bilateral temporal accelerated 40‐Hz tACS improves cognitive function in patients with Alzheimer's disease. Resting‐state fNIRS identifies treatment‐related increases in frontotemporoparietal functional connectivity, which are associated with cognitive improvement. ABSTRACT The temporal lobes are key hubs for memory and cognition.
Rong Guo +10 more
wiley +1 more source

Purification and characterization of an amyloidogenic repeat domain from the functional amyloid Pmel17. [PDF]

Protein Expr Purif, 2021
Dean DN, Lee JC.
europepmc +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee +3 more
wiley +1 more source

Multi-modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain

Communications Medicine
Background Unawareness is a behavioral condition characterized by a lack of self-awareness of objective memory decline. In the context of Alzheimer’s Disease (AD), unawareness may develop in predementia stages and contributes to disease severity and ...
Elisenda Bueichekú +6 more
doaj +1 more source

Calmodulin binds the N-terminus of the functional amyloid Orb2A inhibiting fibril formation. [PDF]

PLoS One, 2022
Soria MA, Cervantes SA, Siemer AB.
europepmc +1 more source

Zinc Fingers as Programmable Metalloprotein Scaffolds for Altering Pathogenic Biomolecular Phase Transitions

Advanced Science, EarlyView.
Modular zinc finger (ZF) metalloproteins function as programmable biomolecular scaffolds that modulate pathogenic amyloid assembly. Through direct protein–protein interactions, ZF arrays alter amyloid phase behavior and redirect β‐sheet fibrillization toward nontoxic aggregates.
Seongmin Park +16 more
wiley +1 more source

Functional network phenotypes of mild behavioural impairment: cognitive effects moderated by amyloid

Alzheimer’s Research & Therapy
Background Mild behavioural impairment (MBI) is a neurobehavioural syndrome that represents an at-risk state for incident cognitive decline. No study to date has systematically investigated whole-brain within- and between- network functional connectivity
Kok Pin Ng +10 more
doaj +1 more source

Blocking Serum Amyloid-P Component from Binding to Macrophages and Augmenting Fungal Functional Amyloid Increases Macrophage Phagocytosis of Candida albicans. [PDF]

Pathogens, 2022
Klotz SA, Bradley N, Lipke PN.
europepmc +1 more source

Duodenum amyloid deposition - Congo Red

, 2005
Duodenum with amyloid deposition in lamina propria. Amyloid etiology unknown. Amyloid shows up as homogenous bright pink material in lamina propria and around blood vessels after staining with congo red ...

core

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao +8 more
wiley +1 more source

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