Results 11 to 20 of about 1,288,108 (273)
Reconstituted Fusion Pore [PDF]
Biophysical Journal, 2003 Fusion pores or porosomes are basket-like structures at the cell plasma membrane, at the base of which, membrane-bound secretory vesicles dock and fuse to release vesicular contents.
Stromer, Marvin H. +4 more
core +4 more sources
The exocytotic fusion pore modeled as a lipidic pore [PDF]
Biophysical Journal, 1992 Freeze-fracture electron micrographs from degranulating cells show that the lumen of the secretory granule is connected to the extracellular compartment via large (20 to 150 nm diameter) aqueous pores.
Fernandez, J.M. +3 more
core +3 more sources
The mystery of the fusion pore. [PDF]
Nat Struct Mol Biol, 2016 Release of neurotransmitters occurs by opening of a fusion pore in a manner thought to be mediated by SNARE proteins, but whether the fusion pore is a lipidic or a proteinaceous structure is controversial.
Sharma S, Lindau M.
europepmc +6 more sources
The fusion pore, 60 years after the first cartoon [PDF]
FEBS Letters, 2018 Neurotransmitter release occurs in the form of quantal events by fusion of secretory vesicles with the plasma membrane, and begins with the formation of a fusion pore that has a conductance similar to that of a large ion channel or gap junction.
Manfred Lindau
exaly +3 more sources
Fusion Pore Diameter Regulation by Cations Modulating Local Membrane Anisotropy [PDF]
The Scientific World Journal, 2012 The fusion pore is an aqueous channel that is formed upon the fusion of the vesicle membrane with the plasma membrane. Once the pore is open, it may close again (transient fusion) or widen completely (full fusion) to permit vesicle cargo discharge. While
Doron Kabaso +5 more
doaj +2 more sources
Fusion pores with low conductance are cation selective [PDF]
Cell Reports, 2021 Summary: Many neurotransmitters are organic ions that carry a net charge, and their release from secretory vesicles is therefore an electrodiffusion process.
Joannalyn B. Delacruz +5 more
doaj +4 more sources
Myomerger promotes fusion pore by elastic coupling between proximal membrane leaflets and hemifusion diaphragm [PDF]
Nature Communications, 2021 Myomerger mediates the transition from the early hemifusion stage to complete fusion during the formation of multinucleated muscle cells. Here, authors use theoretical modeling and cell fusion experiments to show that Myomerger promotes a fusion pore by ...
Gonen Golani +8 more
doaj +2 more sources
High transmembrane voltage raised by close contact initiates fusion pore [PDF]
Frontiers in Molecular Neuroscience, 2016 Membrane fusion lies at the heart of neuronal communication but the detailed mechanism of a critical step, fusion pore initiation, remains poorly understood.
Bing Bu +3 more
doaj +2 more sources
Dilation of fusion pores by crowding of SNARE proteins
eLife, 2017 Hormones and neurotransmitters are released through fluctuating exocytotic fusion pores that can flicker open and shut multiple times. Cargo release and vesicle recycling depend on the fate of the pore, which may reseal or dilate irreversibly.
Zhenyong Wu +7 more
doaj +5 more sources
α-Synuclein kinetically regulates the nascent fusion pore dynamics [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2021 Nellikka RK +4 more
exaly +2 more sources