Results 31 to 40 of about 1,811,201 (303)
Three membrane fusion pore families determine the pathway to pore dilation. [PDF]
Biophys J, 2023 AbstractDuring exocytosis secretory vesicles fuse with a target membrane and release neurotransmitters, hormones or other bioactive molecules through a membrane fusion pore. The initially small pore may subsequently dilate for full contents release, as commonly observed in amperometric traces.
Su R +3 more
europepmc +4 more sources
Asymmetric Phosphatidylethanolamine Distribution Controls Fusion Pore Lifetime and Probability. [PDF]
Biophys J, 2017 Kreutzberger AJB +5 more
europepmc +2 more sources
The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores
eLife, 2021 All membrane fusion reactions proceed through an initial fusion pore, including calcium-triggered release of neurotransmitters and hormones. Expansion of this small pore to release cargo is energetically costly and regulated by cells, but the mechanisms ...
Zhenyong Wu +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Impaired insulin release is a hallmark of type 2 diabetes and is closely related to chronically elevated glucose concentrations, known as “glucotoxicity.” However, the molecular mechanisms by which glucotoxicity impairs insulin secretion remain poorly ...
Guoyi Yang +9 more
doaj +1 more source
Reconstituted Fusion Pore [PDF]
Biophysical Journal, 2003 Fusion pores or porosomes are basket-like structures at the cell plasma membrane, at the base of which, membrane-bound secretory vesicles dock and fuse to release vesicular contents. Earlier studies using atomic force microscopy (AFM) demonstrated the presence of fusion pores at the cell plasma membrane in a number of live secretory cells, revealing ...
Jeremic, Aleksandar +4 more
openaire +2 more sources
Fusion proteins and fusion pores [PDF]
EMBO reports, 2000 Sponsored by the Juan March Foundation and organized by R D Burgoyne and G Alvarez de Toledo, Madrid, Spain, May 22–24, 2000. ![][1] A meeting was recently held at the Juan March Foundation in Madrid (22–24 May, 2000) on the topic ‘Regulated exocytosis and the vesicle cycle’.
Robert D Burgoyne +1 more
openaire +1 more source
The formation of nodular structures in the top layer of ultrafiltration membranes [PDF]
, 1994 The formation of nodular structures in the top layer of ultrafiltration membranes is considered. A critical review of mechanisms described in the literature is given.
Smolders, C.A. +4 more
core +13 more sources
α-Synuclein is required for sperm exocytosis at a post-fusion stage
Frontiers in Cell and Developmental Biology, 2023 The sperm acrosome is a large dense-core granule whose contents are secreted by regulated exocytosis at fertilization through the opening of numerous fusion pores between the acrosomal and plasma membranes. In other cells, the nascent pore generated when
Micaela Vanina Buzzatto +9 more
doaj +1 more source
The beginning and the end of SNARE‐induced membrane fusion
FEBS Open Bio, 2022 Membrane fusion is not a spontaneous process. Physiologically, the formation of coiled‐coil protein complexes, the SNAREpins, bridges the membrane of a vesicle and a target membrane, brings them in close contact, and provides the energy necessary for ...
Delphine Mion +3 more
doaj +1 more source
eLife, 2020 Vesicle fusion is mediated by assembly of SNARE proteins between opposing membranes. While previous work suggested an active role of SNARE transmembrane domains (TMDs) in promoting membrane merger (Dhara et al., 2016), the underlying mechanism remained ...
Madhurima Dhara +5 more
doaj +1 more source