Results 41 to 50 of about 1,811,201 (303)
Fusion pores with low conductance are cation selective
Cell Reports, 2021 Summary: Many neurotransmitters are organic ions that carry a net charge, and their release from secretory vesicles is therefore an electrodiffusion process.
Joannalyn B. Delacruz +5 more
doaj +1 more source
Vesicle Shrinking and Enlargement Play Opposing Roles in the Release of Exocytotic Contents
Cell Reports, 2020 Summary: For decades, two fusion modes were thought to control hormone and transmitter release essential to life; one facilitates release via fusion pore dilation and flattening (full collapse), and the other limits release by closing a narrow fusion ...
Wonchul Shin +11 more
doaj +1 more source
Vesicular control of fusion pore expansion. [PDF]
Commun Integr Biol, 2015 Exocytic post-fusion events play an important role determining the composition and quantity of cellular secretion. In particular, Ca(2+)-dependent regulation of fusion pore dilation/closure is a key regulator for fine-tuning vesicle content secretion. This requires a tight temporal and spatial integration of vesicle fusion with the PM, Ca(2+) signals ...
Neuland K, Frick M.
europepmc +3 more sources
Nature Communications, 2021 Keyhole porosity is a key concern in laser powder-bed fusion (LPBF), potentially impacting component fatigue life. However, some keyhole porosity formation mechanisms, e.g., keyhole fluctuation, collapse and bubble growth and shrinkage, remain unclear ...
Yuze Huang +7 more
semanticscholar +1 more source
The Journal of Physical Chemistry Letters, 2020 Biological transmission of vesicular content occurs by opening of a fusion pore. Recent experimental observations have illustrated that fusion pores between vesicles that are docked by an extended flat contact zone are located at the edge (vertex) of this zone. We modeled this experimentally observed scenario by coarse-grained molecular simulations and
Blokhuis, Edgar M +3 more
openaire +7 more sources
Minimal Aggregate Size and Minimal Fusion Unit for the First Fusion Pore of Influenza Hemagglutinin-Mediated Membrane Fusion [PDF]
, 2000 The data of Melikyan et al. (J. Gen. Physiol. 106:783, 1995) for the time required for the first measurable step of fusion, the formation of the first flickering conductivity pore between influenza hemagglutinin (HA) expressing cells and planar bilayers,
Joe Bentz +57 more
core +4 more sources
Ketamine Alters Functional Plasticity of Astroglia: An Implication for Antidepressant Effect
Life, 2021 Ketamine, a non-competitive N–methyl–d–aspartate receptor (NMDAR) antagonist, exerts a rapid, potent and long-lasting antidepressant effect, although the cellular and molecular mechanisms of this action are yet to be clarified.
Matjaž Stenovec
doaj +1 more source
Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion. [PDF]
, 2012 The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle-vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence of ...
Brunger, Axel T +13 more
core +1 more source
The rab3A-22A chimera prevents sperm exocytosis by stabilizing open fusion pores [PDF]
, 2016 At the final stage of exocytotis, a fusion pore opens between the plasma and a secretory vesicle membranes; typically, when the pore dilates the vesicle releases its cargo.
Bustos, Matias Alberto +5 more
core +1 more source